Literature DB >> 3680172

Genetic studies of avermectin biosynthesis in Streptomyces avermitilis.

H Ikeda1, H Kotaki, S Omura.   

Abstract

A genetic recombination study of an industrial strain of Streptomyces avermitilis which produces avermectin is described. A genetic map has been constructed by analysis of haploid recombinants and linkage relationships of 16 marker loci. Fifteen avermectin-nonproducing mutants, produced by mutagenesis, were classified into two phenotypically different groups, of which one produced avermectin aglycon and the other was able to convert avermectin aglycon to avermectins. Two different mutants were found to map closely to each other.

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Year:  1987        PMID： 3680172      PMCID： PMC214006          DOI： 10.1128/jb.169.12.5615-5621.1987

Source DB:  PubMed          Journal:  J Bacteriol        ISSN： 0021-9193            Impact factor:   3.490


  12 in total

Review 1.  Genetic analysis and genome structure in Streptomyces coelicolor.

Authors:  D A Hopwood
Journal:  Bacteriol Rev       Date:  1967-12

2.  A new kind of fertility variant in Streptomyces coelicolor.

Authors:  D A Hopwood; R J Harold; A Vivian; H M Ferguson
Journal:  Genetics       Date:  1969-07       Impact factor: 4.562

3.  Genetic recombination in Streptomyces bikiniensis var. zorbonensis.

Authors:  J H Coats; J Roeser
Journal:  J Bacteriol       Date:  1971-03       Impact factor: 3.490

4.  Genetics of actinorhodin biosynthesis by Streptomyces coelicolor A3(2).

Authors:  B A Rudd; D A Hopwood
Journal:  J Gen Microbiol       Date:  1979-09

5.  A pigmented mycelial antibiotic in Streptomyces coelicolor: control by a chromosomal gene cluster.

Authors:  B A Rudd; D A Hopwood
Journal:  J Gen Microbiol       Date:  1980-08

6.  The linkage map of Streptomyces rimosus.

Authors:  E J Friend; D A Hopwood
Journal:  J Gen Microbiol       Date:  1971-10

7.  Properties of Streptomyces fradiae mutants blocked in biosynthesis of the macrolide antibiotic tylosin.

Authors:  R H Baltz; E T Seno
Journal:  Antimicrob Agents Chemother       Date:  1981-08       Impact factor: 5.191

8.  Mutangenesis by N-methyl-N'-nitro-N-nitrosoguanidine (NTG) in Streptomyces coelicolor.

Authors:  V Delić; D A Hopwood; E J Friend
Journal:  Mutat Res       Date:  1970-02       Impact factor: 2.433

9.  Avermectins, new family of potent anthelmintic agents: producing organism and fermentation.

Authors:  R W Burg; B M Miller; E E Baker; J Birnbaum; S A Currie; R Hartman; Y L Kong; R L Monaghan; G Olson; I Putter; J B Tunac; H Wallick; E O Stapley; R Oiwa; S Omura
Journal:  Antimicrob Agents Chemother       Date:  1979-03       Impact factor: 5.191

10.  Demethylavermectins. Biosynthesis, isolation and characterization.

Authors:  M D Schulman; D Valentino; O D Hensens; D Zink; M Nallin; L Kaplan; D A Ostlind
Journal:  J Antibiot (Tokyo)       Date:  1985-11       Impact factor: 2.649
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  27 in total

1.  Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.

Authors:  H Ikeda; T Nonomiya; M Usami; T Ohta; S Omura
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

2.  Avenolide, a Streptomyces hormone controlling antibiotic production in Streptomyces avermitilis.

Authors:  Shigeru Kitani; Kiyoko T Miyamoto; Satoshi Takamatsu; Elisa Herawati; Hiroyuki Iguchi; Kouhei Nishitomi; Miho Uchida; Tohru Nagamitsu; Satoshi Omura; Haruo Ikeda; Takuya Nihira
Journal:  Proc Natl Acad Sci U S A       Date:  2011-09-19       Impact factor: 11.205

Review 3.  Thom Award Lecture. Trends in the search for bioactive microbial metabolites.

Authors:  S Omura
Journal:  J Ind Microbiol       Date:  1992-09

Review 4.  Genome mining of the Streptomyces avermitilis genome and development of genome-minimized hosts for heterologous expression of biosynthetic gene clusters.

Authors:  Haruo Ikeda; Shin-ya Kazuo; Satoshi Omura
Journal:  J Ind Microbiol Biotechnol       Date:  2013-08-29       Impact factor: 3.346

5.  Ivermectin activates GIRK channels in a PIP2 -dependent, Gβγ -independent manner and an amino acid residue at the slide helix governs the activation.

Authors:  I-Shan Chen; Michihiro Tateyama; Yuko Fukata; Motonari Uesugi; Yoshihiro Kubo
Journal:  J Physiol       Date:  2017-07-30       Impact factor: 5.182

6.  Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes.

Authors:  Yukinori Tanaka; Mamoru Komatsu; Susumu Okamoto; Shinji Tokuyama; Akira Kaji; Haruo Ikeda; Kozo Ochi
Journal:  Appl Environ Microbiol       Date:  2009-05-15       Impact factor: 4.792

7.  Engineered Streptomyces avermitilis host for heterologous expression of biosynthetic gene cluster for secondary metabolites.

Authors:  Mamoru Komatsu; Kyoko Komatsu; Hanae Koiwai; Yuuki Yamada; Ikuko Kozone; Miho Izumikawa; Junko Hashimoto; Motoki Takagi; Satoshi Omura; Kazuo Shin-ya; David E Cane; Haruo Ikeda
Journal:  ACS Synth Biol       Date:  2013-01-17       Impact factor: 5.110

8.  Cloning of separate meilingmycin biosynthesis gene clusters by use of acyltransferase-ketoreductase didomain PCR amplification.

Authors:  Yunlong He; Yuhui Sun; Tiangang Liu; Xiufen Zhou; Linquan Bai; Zixin Deng
Journal:  Appl Environ Microbiol       Date:  2010-03-26       Impact factor: 4.792

9.  Common biosynthetic origins for polycyclic tetramate macrolactams from phylogenetically diverse bacteria.

Authors:  Joshua A V Blodgett; Dong-Chan Oh; Shugeng Cao; Cameron R Currie; Roberto Kolter; Jon Clardy
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-14       Impact factor: 11.205

10.  Deletion analysis of the avermectin biosynthetic genes of Streptomyces avermitilis by gene cluster displacement.

Authors:  T MacNeil; K M Gewain; D J MacNeil
Journal:  J Bacteriol       Date:  1993-05       Impact factor: 3.490
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