Literature DB >> 7229612

A pigmented mycelial antibiotic in Streptomyces coelicolor: control by a chromosomal gene cluster.

B A Rudd, D A Hopwood.   

Abstract

Streptomyces coelicolor was found to produce a third secondary metabolite, in addition to the antibiotics methylenomycin A and actinorhodin previously described. This is a red pigmented, highly non-polar compound with antibiotic activity against certain Gram-positive bacteria. Mutants lacking the red compound fell into five cosynthetic classes. Representatives of each of the five classes were mapped to the chromosome of the producing organism, in a closely linked cluster. Genetic studies provided evidence that this new metabolite is distinct from actinorhodin and indicated that the two pigments do not share parts of the same biosynthetic pathway.

Entities:  

Mesh：

Substances：

Year:  1980        PMID： 7229612     DOI： 10.1099/00221287-119-2-333

Source DB:  PubMed          Journal:  J Gen Microbiol        ISSN： 0022-1287


  33 in total

1.  Characterization of the pathway-specific positive transcriptional regulator for actinorhodin biosynthesis in Streptomyces coelicolor A3(2) as a DNA-binding protein.

Authors:  P Arias; M A Fernández-Moreno; F Malpartida
Journal:  J Bacteriol       Date:  1999-11       Impact factor: 3.490

2.  Accumulation of S-adenosyl-L-methionine enhances production of actinorhodin but inhibits sporulation in Streptomyces lividans TK23.

Authors:  Dong-Jin Kim; Jung-Hyun Huh; Young-Yell Yang; Choong-Min Kang; In-Hyung Lee; Chang-Gu Hyun; Soon-Kwang Hong; Joo-Won Suh
Journal:  J Bacteriol       Date:  2003-01       Impact factor: 3.490

3.  Genome sequence of the cycloprodigiosin-producing bacterial strain Pseudoalteromonas rubra ATCC 29570(T).

Authors:  Bin-Bin Xie; Yan-Li Shu; Qi-Long Qin; Jin-Cheng Rong; Xi-Ying Zhang; Xiu-Lan Chen; Bai-Cheng Zhou; Yu-Zhong Zhang
Journal:  J Bacteriol       Date:  2012-03       Impact factor: 3.490

4.  Genetic analysis of absB, a Streptomyces coelicolor locus involved in global antibiotic regulation.

Authors:  T Adamidis; W Champness
Journal:  J Bacteriol       Date:  1992-07       Impact factor: 3.490

5.  Global negative regulation of Streptomyces coelicolor antibiotic synthesis mediated by an absA-encoded putative signal transduction system.

Authors:  P Brian; P J Riggle; R A Santos; W C Champness
Journal:  J Bacteriol       Date:  1996-06       Impact factor: 3.490

Review 6.  Actinomycetes biosynthetic potential: how to bridge in silico and in vivo?

Authors:  Yuriy Rebets; Elke Brötz; Bogdan Tokovenko; Andriy Luzhetskyy
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-15       Impact factor: 3.346

7.  Mutations in a new Streptomyces coelicolor locus which globally block antibiotic biosynthesis but not sporulation.

Authors:  T Adamidis; P Riggle; W Champness
Journal:  J Bacteriol       Date:  1990-06       Impact factor: 3.490

Review 8.  Exploitation of the Streptomyces coelicolor A3(2) genome sequence for discovery of new natural products and biosynthetic pathways.

Authors:  Gregory L Challis
Journal:  J Ind Microbiol Biotechnol       Date:  2013-12-10       Impact factor: 3.346

9.  Transcriptional regulation of Streptomyces coelicolor pathway-specific antibiotic regulators by the absA and absB loci.

Authors:  D J Aceti; W C Champness
Journal:  J Bacteriol       Date:  1998-06       Impact factor: 3.490

10.  Nucleotide sequence and transcriptional analysis of the redD locus of Streptomyces coelicolor A3(2).

Authors:  K E Narva; J S Feitelson
Journal:  J Bacteriol       Date:  1990-01       Impact factor: 3.490
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.