Literature DB >> 19447953

Antibiotic overproduction by rpsL and rsmG mutants of various actinomycetes.

Yukinori Tanaka1, Mamoru Komatsu, Susumu Okamoto, Shinji Tokuyama, Akira Kaji, Haruo Ikeda, Kozo Ochi.   

Abstract

Certain streptomycin resistance mutations (i.e., rpsL and rsmG) result in the overproduction of antibiotics in various actinomycetes. Moreover, rpsL rsmG double-mutant strains show a further increase in antibiotic production. rpsL but not rsmG mutations result in a marked enhancement of oligomycin production in Streptomyces avermitilis and erythromycin production in Saccharopolyspora erythraea, accompanied by increased transcription of a key developmental regulator gene, bldD, in the latter organism.

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Year:  2009        PMID： 19447953      PMCID： PMC2708438          DOI： 10.1128/AEM.00681-09

Source DB:  PubMed          Journal:  Appl Environ Microbiol        ISSN： 0099-2240            Impact factor:   4.792


  23 in total

1.  An aberrant protein synthesis activity is linked with antibiotic overproduction in rpsL mutants of Streptomyces coelicolor A3(2).

Authors:  Yoshiko Okamoto-Hosoya; Takeshi Hosaka; Kozo Ochi
Journal:  Microbiology (Reading)       Date:  2003-11       Impact factor: 2.777

Review 2.  Ribosome engineering and secondary metabolite production.

Authors:  Kozo Ochi; Susumu Okamoto; Yuzuru Tozawa; Takashi Inaoka; Takeshi Hosaka; Jun Xu; Kazuhiko Kurosawa
Journal:  Adv Appl Microbiol       Date:  2004       Impact factor: 5.086

3.  A novel insertion mutation in Streptomyces coelicolor ribosomal S12 protein results in paromomycin resistance and antibiotic overproduction.

Authors:  Guojun Wang; Takashi Inaoka; Susumu Okamoto; Kozo Ochi
Journal:  Antimicrob Agents Chemother       Date:  2008-12-22       Impact factor: 5.191

4.  Increased expression of ribosome recycling factor is responsible for the enhanced protein synthesis during the late growth phase in an antibiotic-overproducing Streptomyces coelicolor ribosomal rpsL mutant.

Authors:  Takeshi Hosaka; Jun Xu; Kozo Ochi
Journal:  Mol Microbiol       Date:  2006-07-12       Impact factor: 3.501

5.  Characterization of a regulatory gene, aveR, for the biosynthesis of avermectin in Streptomyces avermitilis.

Authors:  Shigeru Kitani; Haruo Ikeda; Takako Sakamoto; Satoru Noguchi; Takuya Nihira
Journal:  Appl Microbiol Biotechnol       Date:  2009-01-16       Impact factor: 4.813

6.  Transposon mutagenesis by Tn4560 and applications with avermectin-producing Streptomyces avermitilis.

Authors:  H Ikeda; Y Takada; C H Pang; H Tanaka; S Omura
Journal:  J Bacteriol       Date:  1993-04       Impact factor: 3.490

7.  The regulator of streptomycin gene expression, StrR, of Streptomyces griseus is a DNA binding activator protein with multiple recognition sites.

Authors:  L Retzlaff; J Distler
Journal:  Mol Microbiol       Date:  1995-10       Impact factor: 3.501

8.  Feast or famine: the global regulator DasR links nutrient stress to antibiotic production by Streptomyces.

Authors:  Sébastien Rigali; Fritz Titgemeyer; Sharief Barends; Suzanne Mulder; Andreas W Thomae; David A Hopwood; Gilles P van Wezel
Journal:  EMBO Rep       Date:  2008-05-30       Impact factor: 8.807

9.  High-frequency fusion of Streptomyces parvulus or Streptomyces antibioticus protoplasts induced by polyethylene glycol.

Authors:  K Ochi; M J Hitchcock; E Katz
Journal:  J Bacteriol       Date:  1979-09       Impact factor: 3.490

10.  Dramatic activation of antibiotic production in Streptomyces coelicolor by cumulative drug resistance mutations.

Authors:  Guojun Wang; Takeshi Hosaka; Kozo Ochi
Journal:  Appl Environ Microbiol       Date:  2008-02-29       Impact factor: 4.792
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  33 in total

Review 1.  Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters.

Authors:  Richard H Baltz
Journal:  J Ind Microbiol Biotechnol       Date:  2010-05-14       Impact factor: 3.346

Review 2.  Genetic manipulation of secondary metabolite biosynthesis for improved production in Streptomyces and other actinomycetes.

Authors:  Richard H Baltz
Journal:  J Ind Microbiol Biotechnol       Date:  2015-09-12       Impact factor: 3.346

Review 3.  Triggers and cues that activate antibiotic production by actinomycetes.

Authors:  Hua Zhu; Stephanie K Sandiford; Gilles P van Wezel
Journal:  J Ind Microbiol Biotechnol       Date:  2013-08-02       Impact factor: 3.346

Review 4.  Activating the expression of bacterial cryptic genes by rpoB mutations in RNA polymerase or by rare earth elements.

Authors:  Kozo Ochi; Yukinori Tanaka; Shigeo Tojo
Journal:  J Ind Microbiol Biotechnol       Date:  2013-10-15       Impact factor: 3.346

5.  Structuring Microbial Metabolic Responses to Multiplexed Stimuli via Self-Organizing Metabolomics Maps.

Authors:  Cody R Goodwin; Brett C Covington; Dagmara K Derewacz; C Ruth McNees; John P Wikswo; John A McLean; Brian O Bachmann
Journal:  Chem Biol       Date:  2015-04-30

Review 6.  Strain improvement in actinomycetes in the postgenomic era.

Authors:  Richard H Baltz
Journal:  J Ind Microbiol Biotechnol       Date:  2011-01-21       Impact factor: 3.346

7.  Development, antibiotic production, and ribosome assembly in Streptomyces venezuelae are impacted by RNase J and RNase III deletion.

Authors:  Stephanie E Jones; Vivian Leong; Joaquin Ortega; Marie A Elliot
Journal:  J Bacteriol       Date:  2014-09-29       Impact factor: 3.490

Review 8.  Insights into microbial cryptic gene activation and strain improvement: principle, application and technical aspects.

Authors:  Kozo Ochi
Journal:  J Antibiot (Tokyo)       Date:  2016-07-06       Impact factor: 2.649

9.  Activation and products of the cryptic secondary metabolite biosynthetic gene clusters by rifampin resistance (rpoB) mutations in actinomycetes.

Authors:  Yukinori Tanaka; Ken Kasahara; Yutaka Hirose; Kiriko Murakami; Rie Kugimiya; Kozo Ochi
Journal:  J Bacteriol       Date:  2013-04-19       Impact factor: 3.490

10.  A practical and scalable manufacturing process for an anti-fungal agent, Nikkomycin Z.

Authors:  Christopher J Stenland; Lev G Lis; Frederick J Schendel; Nicholas J Hahn; Mary A Smart; Amy L Miller; Marc G von Keitz; Vadim J Gurvich
Journal:  Org Process Res Dev       Date:  2013-01-17       Impact factor: 3.317
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