Literature DB >> 3608993

Sequences controlling histone H4 mRNA abundance.

O Capasso, G C Bleecker, N Heintz.   

Abstract

The post-transcriptional regulation of histone mRNA abundance is manifest both by accumulation of histone mRNA during the S phase, and by the rapid degradation of mature histone mRNA following the inhibition of DNA synthesis. We have constructed a comprehensive series of substitution mutants within a human H4 histone gene, introduced them into the mouse L cell genome, and analyzed their effects on the post-transcriptional control of the H4 mRNA. Our results demonstrate that most of the H4 mRNA is dispensable for proper regulation of histone mRNA abundance. However, recognition of the 3' terminus of the mature H4 mRNA is critically important for regulating its cytoplasmic half-life. Thus, this region of the mRNA functions both in the nucleus as a signal for proper processing of the mRNA terminus, and in the cytoplasm as an essential element in the control of mRNA stability.

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Year:  1987        PMID： 3608993      PMCID： PMC553561          DOI： 10.1002/j.1460-2075.1987.tb02437.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  23 in total

1.  Kinetics of inactivation of histone mRNA in the cytoplasm after inhibition of DNA replication in synchronised HeLa cells.

Authors:  D Gallwitz
Journal:  Nature       Date:  1975-09-18       Impact factor: 49.962

2.  Further evidence of transcriptional and translational control of histone messenger RNA during the HeLa S3 cycle.

Authors:  T W Borun; F Gabrielli; K Ajiro; A Zweidler; C Baglioni
Journal:  Cell       Date:  1975-01       Impact factor: 41.582

3.  Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.

Authors:  A J Berk; P A Sharp
Journal:  Cell       Date:  1977-11       Impact factor: 41.582

4.  Rapidly labeled, polyribosome-associated RNA having the properties of histone messenger.

Authors:  T W Borun; M D Scharff; E Robbins
Journal:  Proc Natl Acad Sci U S A       Date:  1967-11       Impact factor: 11.205

5.  Regulation of human histone gene expression: kinetics of accumulation and changes in the rate of synthesis and in the half-lives of individual histone mRNAs during the HeLa cell cycle.

Authors:  N Heintz; H L Sive; R G Roeder
Journal:  Mol Cell Biol       Date:  1983-04       Impact factor: 4.272

6.  Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

Authors:  P J Southern; P Berg
Journal:  J Mol Appl Genet       Date:  1982

7.  Histone mRNA concentrations are regulated at the level of transcription and mRNA degradation.

Authors:  D B Sittman; R A Graves; W F Marzluff
Journal:  Proc Natl Acad Sci U S A       Date:  1983-04       Impact factor: 11.205

8.  Reassessment of histone gene expression during cell cycle in human cells by using homologous H4 histone cDNA.

Authors:  S Detke; A Lichtler; I Phillips; J Stein; G Stein
Journal:  Proc Natl Acad Sci U S A       Date:  1979-10       Impact factor: 11.205

9.  Arrest of cultured cells in the G1 phase of the cell cycle by indomethacin.

Authors:  B M Bayer; H S Kruth; M Vaughan; M A Beaven
Journal:  J Pharmacol Exp Ther       Date:  1979-07       Impact factor: 4.030

10.  A signal regulating mouse histone H4 mRNA levels in a mammalian cell cycle mutant and sequences controlling RNA 3' processing are both contained within the same 80-bp fragment.

Authors:  C Stauber; B Lüscher; R Eckner; E Lötscher; D Schümperli
Journal:  EMBO J       Date:  1986-12-01       Impact factor: 11.598
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  25 in total

1.  A plant histone gene promoter can direct both replication-dependent and -independent gene expression in transgenic plants.

Authors:  M Lepetit; M Ehling; N Chaubet; C Gigot
Journal:  Mol Gen Genet       Date:  1992-01

2.  The adenovirus type 5 i-leader open reading frame functions in cis to reduce the half-life of L1 mRNAs.

Authors:  P D Soloway; T Shenk
Journal:  J Virol       Date:  1990-02       Impact factor: 5.103

3.  Changes in the stability of a human H3 histone mRNA during the HeLa cell cycle.

Authors:  T D Morris; L A Weber; E Hickey; G S Stein; J L Stein
Journal:  Mol Cell Biol       Date:  1991-01       Impact factor: 4.272

4.  The histone 3'-terminal stem-loop is necessary for translation in Chinese hamster ovary cells.

Authors:  D R Gallie; N J Lewis; W F Marzluff
Journal:  Nucleic Acids Res       Date:  1996-05-15       Impact factor: 16.971

Review 5.  Translational control of cellular and viral mRNAs.

Authors:  D R Gallie
Journal:  Plant Mol Biol       Date:  1996-10       Impact factor: 4.076

6.  Differential stability of Xenopus c-myc RNA during oogenesis in axolotl Involvement of the 3' untranslated region in vivo.

Authors:  Y Andéol; J Lefresne; Ch Houillon; J Signoret
Journal:  Rouxs Arch Dev Biol       Date:  1995-11

7.  Introns in histone genes alter the distribution of 3' ends.

Authors:  N B Pandey; N Chodchoy; T J Liu; W F Marzluff
Journal:  Nucleic Acids Res       Date:  1990-06-11       Impact factor: 16.971

8.  Alternative mRNA splicing generates multiple forms of peptidyl-glycine alpha-amidating monooxygenase in rat atrium.

Authors:  D A Stoffers; C B Green; B A Eipper
Journal:  Proc Natl Acad Sci U S A       Date:  1989-01       Impact factor: 11.205

9.  Evolutionary conserved multiprotein complexes interact with the 3' untranslated region of histone transcripts.

Authors:  R Eckner; M L Birnstiel
Journal:  Nucleic Acids Res       Date:  1992-03-11       Impact factor: 16.971

10.  Nonsense codons in human beta-globin mRNA result in the production of mRNA degradation products.

Authors:  S K Lim; C D Sigmund; K W Gross; L E Maquat
Journal:  Mol Cell Biol       Date:  1992-03       Impact factor: 4.272
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