| Literature DB >> 3580260 |
S L Thein, A J Jeffreys, H C Gooi, F Cotter, J Flint, N T O'Connor, D J Weatherall, J S Wainscoat.
Abstract
Minisatellite DNA probes which can detect a large number of autosomal loci dispersed throughout the human genome were used to examine the constitutional and tumour DNA of 35 patients with a variety of cancers of which eight were of gastrointestinal origin. Somatic changes were seen in the tumour DNA in ten of the 35 cases. The changes included alterations in the relative intensities of hybridising DNA fragments, and, in three cases of cancers of gastrointestinal origin, the appearance of novel minisatellite fragments not seen in the corresponding constitutional DNA. The results of this preliminary study suggests that DNA fingerprint analysis provides a useful technique for identifying somatic changes in cancers.Entities:
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Year: 1987 PMID： 3580260 PMCID： PMC2001711 DOI： 10.1038/bjc.1987.71
Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640