| Literature DB >> 6316147 |
N Heisterkamp, J R Stephenson, J Groffen, P F Hansen, A de Klein, C R Bartram, G Grosveld.
Abstract
The human c-ab1 oncogene maps within the region (q34-qter) of chromosome 9 which is translocated to chromosome 22, the Philadelphia (Ph') chromosome, in chronic myelocytic leukaemia (CML). The position of the Ph' chromosomal break point is shown to be variable and, in one CML patient, has been localized immediately 5' of, or within, the c-ab1 oncogene. A DNA restriction fragment corresponding to this site has been molecularly cloned and shown to represent a chimaeric fragment of DNA from chromosomes 9 and 22.Entities:
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Year: 1983 PMID： 6316147 DOI： 10.1038/306239a0
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962