| Literature DB >> 35604337 |
Thomas C Edwards1, Brogan Guest1, Amy Garner1, Kartik Logishetty1, Alexander D Liddle1, Justin P Cobb1.
Abstract
AIMS: This study investigates the use of the metabolic equivalent of task (MET) score in a young hip arthroplasty population, and its ability to capture additional benefit beyond the ceiling effect of conventional patient-reported outcome measures.Entities:
Keywords: BMI; Ceiling effect; EQ-5D scores; EuroQol five-dimension questionnaire (EQ-5D); Hip arthroplasty; Oxford Hip Scores (OHS); PROMs; Patient-reported outcome measures (PROMs); correlation coefficient; hip; hip arthroplasty surgery; hip resurfacing arthroplasty; revision surgery
Year: 2022 PMID: 35604337 PMCID: PMC9130675 DOI: 10.1302/2046-3758.115.BJR-2021-0445.R1
Source DB: PubMed Journal: Bone Joint Res ISSN: 2046-3758 Impact factor: 4.410
Demographics and patient-reported outcome measures.
| Variable | Data (n = 221) |
|---|---|
| Mean age, yrs (SD, range) | 59.4 (11.3, 31 to 84) |
| Male | 120 (54.3) |
| Female | 101 (45.7) |
|
| |
| Right | 103 (46.6) |
| Left | 110 (49.8) |
| Bilateral | 8 (3.6) |
| Mean BMI, kg/m2 (SD, range) | 26.4 (4.9, 16.0 to 57.5) |
|
| |
| THA | 117 (52.9) |
| HRA | 104 (47.1) |
|
| |
| Mean preoperative (SD, range) | 25.6 (8.3, 6 to 48) |
| Median 1 yr (IQR) | 47 (44 to 48) |
|
| |
| Median preoperative (IQR) | 0.57 (0.30 to 0.65) |
| Median 1 yr (IQR) | 1 (0.77 to 1) |
|
| |
| Median preoperative (IQR) | 4.9 (0 to 7.5) |
| Mean 1 yr (SD, range) | 10.7 (3.8, 0 to 23) |
Missing data, n = 163.
Non-parametric variable, data presented as median (interquartile range), otherwise data reported as mean (standard deviation, range) as indicated.
EQ-5D, EuroQol five-dimension questionnaire; HRA, hip resurfacing arthroplasty; IQR, interquartile range; MET, metabolic equivalent of task; OHS, Oxford Hip Score; SD, standard deviation; THA, total hip arthroplasty.
Fig. 1Histograms with kernel (Epanechnikov) density plots demonstrating distribution of Oxford Hip Scores (OHS) preoperatively and at one-year follow-up. Solid vertical lines represent mean values, dashed vertical lines represent the median.
Fig. 2Histograms with kernel (Epanechnikov) density plots demonstrating distribution of EuroQol-5D (EQ-5D) index scores preoperatively and at one-year follow-up. Solid vertical lines represent mean values, dashed vertical lines represent the median.
Fig. 3Histograms with kernel (Epanechnikov) density plots demonstrating distribution of metabolic equivalent of task (MET) scores preoperatively and at one-year follow-up. Solid vertical lines represent mean values, dashed vertical lines represent the median.
Distribution, ceiling and floor effects, and responsiveness of the three metrics before and after surgery.
| Measure | n | Preoperative | 1-yr postoperative | p- | Mean difference (SD) | SRM | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Mean (SD) | Median | Ceiling effect, % | Floor effect, | Skew | Kurtosis | Mean | Median | Ceiling effect, % | Floor effect, % | Skew | Kurtosis | |||||
| OHS | 221 | 25.6 | 26 | 0.5 | 0.0 | -0.14 | 2.57 | 44.7 (6.2) | 47 | 41.6 | 0.0 | -3.12 | 13.07 | < 0.001 | 19.1 (9.5) | 2.01 |
| EQ-5D | 221 | 0.48 (0.25) | 0.57 (0.3 to 0.6) | 1.4 | 0.0 | -0.99 | 4.03 | 0.83 (0.26) | 1 (0.8 to 1) | 53.8 | 0.0 | -1.96 | 6.23 | < 0.001 | 0.34 (0.32) | 1.06 |
| MET | 221 | 5.1 | 4.9 | 0.0 | 25.3 | 0.59 | 3.18 | 10.7 (3.8) | 10.3 (8.6 to 12.5) | 0.9 | 1.8 | 0.40 | 4.46 | < 0.001 | 5.6 (4.8) | 1.17 |
Ceiling and floor effects calculated as the percentage of patients scoring the maximum and minimum possible scores, respectively. Skewness and kurtosis values numerically represent the distribution of scores. A normal distribution has a skew of 0 and a kurtosis of 3. Standardized response mean calculated as the mean difference in scores divided by the standard deviation of that difference.
Indicates number of included patients.
Paired t-test comparing preoperative and one-year postoperative scores.
EQ-5D, EuroQol five-dimension questionnaire; IQR, interquartile range; MET, metabolic equivalent of task; OHS, Oxford Hip Score; SD, standard deviation; SRM, standardized response mean.
Outcome scores by category for 48/48 Oxford Hip Score sub-cohort.
| Variable | n | MET score | EQ-5D | ||
|---|---|---|---|---|---|
| 1 yr mean (SD, range) | p-value | 1 yr median (IQR) | p-value | ||
|
| 0.008 | 0.371 | |||
| < 60 | 44 | 12.7 (4.7, 0 to 23) | 1 (1 to 1) | ||
| > 60 | 48 | 10.6 (2.4, 6.3 to 17.1) | 1 (1 to 1) | ||
| 0.024 | 0.280 | ||||
| Male | 46 | 12.5 (4.5, 0 to 23) | 1 (1 to 1) | ||
| Female | 46 | 10.8 (2.8, 6.3 to 19.9) | 1 (1 to 1) | ||
|
| 0.040 | 0.248 | |||
| < 6 | 54 | 11.0 (3.3, 0 to 23) | 1 (1 to 1) | ||
| > 6 | 38 | 12.6 (4.2, 6.2 to 23) | 1 (1 to 1) | ||
|
| 0.061 | 0.122 | |||
| < 25 | 32 | 12.2 (3.5, 7.2 to 23) | 1 (1 to 1) | ||
| > 25 | 32 | 10.8 (2.5, 6.3 to 16) | 1 (0.9 to 1) | ||
Except for p-values marked with the † symbol (Mann-Whitney U test), all p-values in this table were calculated using the independent-samples t-test.
Number of patients.
Mann-Whitney U test.
EQ-5D, EuroQol five-dimension questionnaire; IQR, interquartile range; MET, metabolic equivalent of task; SD, standard deviation.
Fig. 4Fractional polynomial regression plots demonstrating predicted improvement in score at one-year follow-up for a given preoperative Oxford Hip Score (OHS) for a) OHS, b) EuroQol five-dimension questionnaire (EQ-5D), and c) metabolic equivalent of task (MET). Fractional polynomial fit line with 95% confidence intervals (CIs) demonstrated in grey.
Fig. 5Histograms with kernel (Epanechnikov) density plots demonstrating distribution of a) metabolic equivalent of task score (MET) and b) EuroQol five-dimension questionnaire (EQ-5D), at one-year follow-up for the subgroup of patients who all scored 48/48 on the Oxford Hip Score (n = 92).
Fig. 6Column scatter for the subgroup of 92 patients scoring 48/48 on the Oxford Hip Score, compared by age group, BMI, preoperative metabolic equivalent of task (MET) score, and sex using: a) MET scores; and b) EuroQol five-dimension questionnaire (EQ-5D) scores. The solid horizontal line represents the median and the whiskers represent the interquartile range. Statistically significant p-values have been indicated.