Elizabeth S Heller Murray1, Jennifer Segawa1, F Isik Karahanoglu2, Catherine Tocci2, Jason A Tourville1, Alfonso Nieto-Castanon1, Helen Tager-Flusberg3, Dara S Manoach2,4, Frank H Guenther1,5. 1. Boston University, Department of Speech, Language, & Hearing Sciences, 635 Commonwealth Avenue, Boston, MA, 02215. 2. Massachusetts General Hospital, Department of Psychiatry, Harvard Medical School, 55 Fruit Street, Boston, MA, 02215. 3. Boston University, Department of Psychological and Brain Sciences, 64 Cummington Mall Boston, MA, 02115. 4. Athinoula A. Martinos Center for Biomedical Imaging, 149 13th Street, Room 2618, Charlestown, MA 02129. 5. Boston University, Department of Biomedical Engineering, 44 Cummington Mall Boston, MA, 02115.
Abstract
Background: Communication difficulties are a core deficit in many people with autism spectrum disorder (ASD). The current study evaluated neural activation in participants with ASD and neurotypical (NT) controls during a speech production task. Methods: Neural activities of participants with ASD (N = 15, M = 16.7 years, language abilities ranged from low verbal abilities to verbally fluent) and NT controls (N = 12, M = 17.1 years) was examined using functional magnetic resonance imaging with a sparse-sampling paradigm. Results: There were no differences between the ASD and NT groups in average speech activation or inter-subject run-to-run variability in speech activation. Intra-subject run-to-run neural variability was greater in the ASD group and was positively correlated with autism severity in cortical areas associated with speech. Conclusions: These findings highlight the importance of understanding intra-subject neural variability in participants with ASD.
Background: Communication difficulties are a core deficit in many people with autism spectrum disorder (ASD). The current study evaluated neural activation in participants with ASD and neurotypical (NT) controls during a speech production task. Methods: Neural activities of participants with ASD (N = 15, M = 16.7 years, language abilities ranged from low verbal abilities to verbally fluent) and NT controls (N = 12, M = 17.1 years) was examined using functional magnetic resonance imaging with a sparse-sampling paradigm. Results: There were no differences between the ASD and NT groups in average speech activation or inter-subject run-to-run variability in speech activation. Intra-subject run-to-run neural variability was greater in the ASD group and was positively correlated with autism severity in cortical areas associated with speech. Conclusions: These findings highlight the importance of understanding intra-subject neural variability in participants with ASD.
Entities:
Keywords:
communication; functional magnetic resonance imaging; speech; variability
Authors: Bruce Fischl; David H Salat; Evelina Busa; Marilyn Albert; Megan Dieterich; Christian Haselgrove; Andre van der Kouwe; Ron Killiany; David Kennedy; Shuna Klaveness; Albert Montillo; Nikos Makris; Bruce Rosen; Anders M Dale Journal: Neuron Date: 2002-01-31 Impact factor: 17.173
Authors: Spencer J Hayes; Matthew Andrew; Nathan C Foster; Digby Elliott; Emma Gowen; Simon J Bennett Journal: Autism Res Date: 2017-10-20 Impact factor: 5.216