Literature DB >> 35526206

Efficient and green synthesis of novel hexahydro-5H-thiazolo[2',3':2,3]pyrimido[4,5-b]quinoline derivatives.

Tooba Tabibi1, Abbas Ali Esmaeili2.   

Abstract

Herein, we report a catalyst-free, one-pot three-component reaction of 5-amino-2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-one, aromatic aldehyde, and dimedone in ethylene glycol as a green solvent at 100 °C for the easy access of hexahydro-5H-thiazolo[2',3':2,3]pyrimido[4,5-b]quinoline. Catalyst-free, green solvent, simple procedure, mild reaction conditions, easy work-up procedure, and good to excellent yields are the significant advantages of this protocol.
© 2022. The Author(s), under exclusive licence to Springer Nature Switzerland AG.

Entities:  

Keywords:  5-Amino-2,3-dihydro-7H-thiazolo[3,2-a]pyrimidin-7-one; Catalyst-free synthesis; Hexahydro-5H-thiazolo[2',3':2,3]pyrimido[4,5-b]quinolines; Three-component reaction

Year:  2022        PMID： 35526206     DOI： 10.1007/s11030-022-10439-z

Source DB:  PubMed          Journal:  Mol Divers        ISSN： 1381-1991            Impact factor:   2.943


  19 in total

1.  Synthesis and biological evaluation of new thiazolopyrimidines.

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2.  New thiazolopyrimidine as anticancer agents: Synthesis, biological evaluation, DNA binding, molecular modeling and ADMET study.

Authors:  Sara T Al-Rashood; Shymaa S Elshahawy; Asmaa M El-Qaias; Dina S El-Behedy; Alshaimaa A Hassanin; Selwan M El-Sayed; Shahenda M El-Messery; Moataz A Shaldam; Ghada S Hassan
Journal:  Bioorg Med Chem Lett       Date:  2020-10-14       Impact factor: 2.823

3.  One-pot synthesis of thiazolo[3,2-a]pyrimidine derivatives, their cytotoxic evaluation and molecular docking studies.

Authors:  Thuraka Sekhar; Pinnu Thriveni; Annavarapu Venkateswarlu; Thathapudi Daveedu; Kotha Peddanna; Sri Bhashyam Sainath
Journal:  Spectrochim Acta A Mol Biomol Spectrosc       Date:  2020-01-15       Impact factor: 4.098

4.  Substituted thiazoles V. synthesis and antitumor activity of novel thiazolo[2,3-b]quinazoline and pyrido[4,3-d]thiazolo[3,2-a]pyrimidine analogues.

Authors:  Fatmah A M Al-Omary; Ghada S Hassan; Shahenda M El-Messery; Hussein I El-Subbagh
Journal:  Eur J Med Chem       Date:  2011-10-20       Impact factor: 6.514

5.  Rapid discovery of triazolobenzylidene-thiazolopyrimidines (TBTP) as CDC25 phosphatase inhibitors by parallel click chemistry and in situ screening.

Authors:  Romain Duval; Stéphanie Kolb; Emmanuelle Braud; David Genest; Christiane Garbay
Journal:  J Comb Chem       Date:  2009 Nov-Dec

6.  Development of novel thiazolopyrimidines as CDC25B phosphatase inhibitors.

Authors:  Stéphanie Kolb; Odile Mondésert; Mary-Lorène Goddard; Denis Jullien; Bruno O Villoutreix; Bernard Ducommun; Christiane Garbay; Emmanuelle Braud
Journal:  ChemMedChem       Date:  2009-04       Impact factor: 3.466

7.  New fused pyrimidine derivatives with anticancer activity: Synthesis, topoisomerase II inhibition, apoptotic inducing activity and molecular modeling study.

Authors:  Mohamed T M Nemr; Asmaa M AboulMagd
Journal:  Bioorg Chem       Date:  2020-07-23       Impact factor: 5.275

8.  Microwave assisted synthesis of some new thiazolopyrimidine, thiazolodipyrimidine and thiazolopyrimidothiazolopyrimidine derivatives with potential antioxidant and antimicrobial activity.

Authors:  Mohamed M Youssef; Mahmoud A Amin
Journal:  Molecules       Date:  2012-08-13       Impact factor: 4.411

9.  Synthesis, Antibacterial and Antitubercular Activities of Some 5H-Thiazolo[3,2-a]pyrimidin-5-ones and Sulfonic Acid Derivatives.

Authors:  Dong Cai; Zhi-Hua Zhang; Yu Chen; Xin-Jia Yan; Liang-Jing Zou; Ya-Xin Wang; Xue-Qi Liu
Journal:  Molecules       Date:  2015-09-10       Impact factor: 4.411

10.  Microwave assisted synthesis of some new thiazolopyrimidine and pyrimidothiazolopyrimidopyrimidine derivatives with potential antimicrobial activity.

Authors:  Ayman M S Youssef; Ahmed M Fouda; Rasha M Faty
Journal:  Chem Cent J       Date:  2018-05-05       Impact factor: 4.215
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