| Literature DB >> 35418686 |
Lei Han1,2,3, Xiaoyu Wei1,4, Chuanyu Liu1,2,3, Giacomo Volpe5, Zhenkun Zhuang1,6, Xuanxuan Zou1,4, Zhifeng Wang1,2, Taotao Pan1,2, Yue Yuan1,4, Xiao Zhang7, Peng Fan7, Pengcheng Guo7, Yiwei Lai8, Ying Lei1,2,3, Xingyuan Liu7, Feng Yu8, Shuncheng Shangguan9, Guangyao Lai9, Qiuting Deng1,4, Ya Liu1,2, Liang Wu1,2,4, Quan Shi1,10, Hao Yu1, Yunting Huang1,11, Mengnan Cheng1,4, Jiangshan Xu1,4, Yang Liu1,4, Mingyue Wang1, Chunqing Wang1,4, Yuanhang Zhang1,4, Duo Xie1,4, Yunzhi Yang12, Yeya Yu12, Huiwen Zheng12, Yanrong Wei12, Fubaoqian Huang1,6, Junjie Lei1,4, Waidong Huang1,4, Zhiyong Zhu1,4, Haorong Lu1,11, Bo Wang1,11, Xiaofeng Wei1,11, Fengzhen Chen1,11, Tao Yang1,11, Wensi Du1,11, Jing Chen1,11, Shibo Xu13, Juan An8,14, Carl Ward8, Zongren Wang15, Zhong Pei16, Chi-Wai Wong17, Xiaolei Liu7, Huafeng Zhang18, Mingyuan Liu7, Baoming Qin19, Axel Schambach20,21, Joan Isern22, Liqiang Feng23, Yan Liu13, Xiangyu Guo24,25, Zhen Liu26, Qiang Sun26, Patrick H Maxwell27, Nick Barker28, Pura Muñoz-Cánoves29, Ying Gu1, Jan Mulder30,31, Mathias Uhlen30,31, Tao Tan32, Shiping Liu1,2,3, Huanming Yang1,33, Jian Wang1,33, Yong Hou34,35,36,37, Xun Xu38,39,40,41, Miguel A Esteban42,43,44, Longqi Liu45,46,47,48.
Abstract
Studying tissue composition and function in non-human primates (NHPs) is crucial to understand the nature of our own species. Here we present a large-scale cell transcriptomic atlas that encompasses over 1 million cells from 45 tissues of the adult NHP Macaca fascicularis. This dataset provides a vast annotated resource to study a species phylogenetically close to humans. To demonstrate the utility of the atlas, we have reconstructed the cell-cell interaction networks that drive Wnt signalling across the body, mapped the distribution of receptors and co-receptors for viruses causing human infectious diseases, and intersected our data with human genetic disease orthologues to establish potential clinical associations. Our M. fascicularis cell atlas constitutes an essential reference for future studies in humans and NHPs.Entities:
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Year: 2022 PMID： 35418686 DOI： 10.1038/s41586-022-04587-3
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962