Literature DB >> 3536802

Immunogold localization of ingested kidney bean (Phaseolus vulgaris) lectins in epithelial cells of the rat small intestine.

T P King, A Pusztai, G Grant, D Slater.   

Abstract

The interactions between dietary kidney bean (Phaseolus vulgaris) lectins and the epithelial cells of the rat small intestine were investigated by immunogold electron microscopy. The results demonstrated that the lectins bind to the glycocalyx of duodenal and jejunal microvilli and that some of these dietary constituents are endocytosed into lysosomal pathways within both absorptive and secretory gut cells. It is concluded that the lysosomal response serves to limit the absorption of nutritionally significant levels of these dietary toxins.

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Year:  1986        PMID： 3536802     DOI： 10.1007/BF01675333

Source DB:  PubMed          Journal:  Histochem J        ISSN： 0018-2214


  10 in total

1.  Immunocytochemical localisation of lectins in cells of Phaseolus vulgaris L. seeds.

Authors:  J F Manen; A Pusztai
Journal:  Planta       Date:  1982-08       Impact factor: 4.116

2.  Nutritional toxicity of raw kidney beans in pigs. Immunocytochemical and cytopathological studies on the gut and the pancreas.

Authors:  T P King; R Begbie; A Cadenhead
Journal:  J Sci Food Agric       Date:  1983-12       Impact factor: 3.638

Review 3.  Endocytic uptake, transport, and catabolism of proteins by epithelial cells.

Authors:  D A Wall; T Maack
Journal:  Am J Physiol       Date:  1985-01

4.  A new method of preparing gold probes for multiple-labeling cytochemistry.

Authors:  J W Slot; H J Geuze
Journal:  Eur J Cell Biol       Date:  1985-07       Impact factor: 4.492

5.  The toxicity of Phaseolus vulgaris lectins. Nitrogen balance and immunochemical studies.

Authors:  A Pusztai; E M Clarke; G Grant; T P King
Journal:  J Sci Food Agric       Date:  1981-10       Impact factor: 3.638

6.  Kidney bean (Phaseolus vulgaris) lectin-induced lesions in the small intestine: 1. Light microscope studies.

Authors:  T P King; A Pusztai; E M Clarke
Journal:  J Comp Pathol       Date:  1980-10       Impact factor: 1.311

7.  The nutrition evaluation of kidney beans (Phaseolus vulgaris). The effect of nutritional value of seed germination and changes in trypsin inhibitor content.

Authors:  R Palmer; A McIntosh; A Pusztai
Journal:  J Sci Food Agric       Date:  1973-08       Impact factor: 3.638

8.  Kidney bean (Phaseolus vulgaris) lectin-induced lesions in rat small intestine. 3. Ultrastructural studies.

Authors:  T P King; A Pusztai; E M Clarke
Journal:  J Comp Pathol       Date:  1982-07       Impact factor: 1.311

9.  Immunocytochemical localization of ingested kidney bean (Phaseolus vulgaris) lectins in rat gut.

Authors:  T P King; A Pusztai; E M Clarke
Journal:  Histochem J       Date:  1980-03

10.  In vivo responses of rat intestinal epithelium to intraluminal dietary lectins.

Authors:  V Lorenzsonn; W A Olsen
Journal:  Gastroenterology       Date:  1982-05       Impact factor: 22.682
  10 in total
  10 in total

1.  Sustained mitogenic effect on K562 human chronic myelogenous leukemia cells by dietary lectin, jacalin.

Authors:  V Lavanya; Neesar Ahmed; Md Khurshid Alam Khan; Shazia Jamal
Journal:  Glycoconj J       Date:  2016-08-19       Impact factor: 2.916

2.  Red kidney bean lectin is a potent cholecystokinin releasing stimulus in the rat inducing pancreatic growth.

Authors:  K H Herzig; S Bardocz; G Grant; R Nustede; U R Fölsch; A Pusztai
Journal:  Gut       Date:  1997-09       Impact factor: 23.059

3.  Isolation and Partial Characterization of a Seed Lectin from Tepary Bean that Delays Bruchid Beetle Development.

Authors:  R C Pratt; N K Singh; R E Shade; L L Murdock; R A Bressan
Journal:  Plant Physiol       Date:  1990-08       Impact factor: 8.340

4.  Acute epithelial injury in the rat small intestine in vivo is associated with expanded expression of transforming growth factor alpha and beta.

Authors:  A U Dignass; J L Stow; M W Babyatsky
Journal:  Gut       Date:  1996-05       Impact factor: 23.059

5.  Effect of the beta-adrenoceptor agonist clenbuterol and phytohaemagglutinin on growth, protein synthesis and polyamine metabolism of tissues of the rat.

Authors:  S Bardocz; D S Brown; G Grant; A Pusztai; J C Stewart; R M Palmer
Journal:  Br J Pharmacol       Date:  1992-06       Impact factor: 8.739

6.  Pathological effects of Phaseolus vulgaris isolectins on pig jejunal mucosa in organ culture.

Authors:  M J Kik; J F Koninkx; A van den Muysenberg; F Hendriksen
Journal:  Gut       Date:  1991-08       Impact factor: 23.059

7.  Binding of kidney bean (Phaseolus vulgaris) isolectins to differentiated human colon carcinoma Caco-2 cells and their effect on cellular metabolism.

Authors:  H G Hendriks; M J Kik; J F Koninkx; T S van den Ingh; J M Mouwen
Journal:  Gut       Date:  1991-02       Impact factor: 23.059

8.  Polyamine metabolism of enterocyte-like Caco-2 cells after exposure to Phaseolus vulgaris lectin.

Authors:  J F Koninkx; D S Brown; W Kok; H G Hendriks; A Pusztai; S Bardocz
Journal:  Gut       Date:  1996-01       Impact factor: 23.059

9.  Potential efficacy of preparations derived from Phaseolus vulgaris in the control of appetite, energy intake, and carbohydrate metabolism.

Authors:  Mauro Am Carai; Noemi Fantini; Barbara Loi; Giancarlo Colombo; Antonella Riva; Paolo Morazzoni
Journal:  Diabetes Metab Syndr Obes       Date:  2009-09-07       Impact factor: 3.168

10.  Targeting receptors, transporters and site of absorption to improve oral drug delivery.

Authors:  J H Hamman; P H Demana; E I Olivier
Journal:  Drug Target Insights       Date:  2007-03-06
  10 in total

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