Literature DB >> 353284

Inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes: a study of repeatability.

K A Fletcher, D A Evans, M V Canning.   

Abstract

Modifications to the method for estimating aryl hydrocarbon hydroxylase (AHH) activity in cultured human lymphocytes are described. Despite the improvements to the technique it was not possible to show significant 'repeatability' of values for AHH induction over a period of 2 weeks or more. Significant repeatability could be seen when a blood sample from each subject was split into duplicates. However, this level of repeatability was low when considered for quantitative genetics purposes. Possible reasons for the poor repeatability have been discussed.

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Year:  1978        PMID： 353284      PMCID： PMC1013675          DOI： 10.1136/jmg.15.3.182

Source DB:  PubMed          Journal:  J Med Genet        ISSN： 0022-2593            Impact factor:   6.318


  15 in total

1.  Aryl-hydrocarbon hydroxylase activity in lymphocytes from lung cancer patients and normal controls.

Authors:  H A Guirgis; H T Lynch; T Mate; R E Harris; I Wells; L Caha; J Anderson; K Maloney; L Rankin
Journal:  Oncology       Date:  1976       Impact factor: 2.935

2.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

3.  Measurement of benzo(a)pyrene metabolism in human monocytes.

Authors:  R S Lake; M R Pezzutti; M L Kropko; A E Freeman; H J Igel
Journal:  Cancer Res       Date:  1977-08       Impact factor: 12.701

4.  Aryl hydrocarbon hydroxylase induction in human lymphocyte cultures by 2,3,7,8-tetrachlorodibenzo-p-dioxin.

Authors:  R R Kouri; H Ratrie; S A Atlas; A Niwa; D W Nebert
Journal:  Life Sci       Date:  1974-11-01       Impact factor: 5.037

5.  Aryl hydrocarbon (benzopyrene) hydroxylase is stimulated in human lymphocytes by mitogens and benz(a)anthracene.

Authors:  J P Whitlock; H L Cooper; V H Gelboin
Journal:  Science       Date:  1972-08-18       Impact factor: 47.728

6.  Aryl hydrocarbon hydroxylase induction by polycyclic hydrocarbons: simple autosomal dominant trait in the mouse.

Authors:  D W Nebert; F M Goujon; J E Gielen
Journal:  Nat New Biol       Date:  1972-03-29

7.  Benzo(a)pyrene metabolites: efficient and rapid separation by high-pressure liquid chromatography.

Authors:  J K Selkirk; R G Croy; H V Gelboin
Journal:  Science       Date:  1974-04-12       Impact factor: 47.728

8.  Aryl hydrocarbon (benzo(a)pyrene) hydroxylase in human peripheral blood monocytes.

Authors:  R C Bast; J P Whitlock; H Miller; H J Rapp; H V Gelboin
Journal:  Nature       Date:  1974-08-23       Impact factor: 49.962

9.  Aryl hydrocarbon hydroxylase and 16alpha-hydroxylase in cultured human lymphocytes.

Authors:  M L Coomes; W A Mason; I E Muijsson; E T Cantrell; D E Anderson; D L Busbee
Journal:  Biochem Genet       Date:  1976-08       Impact factor: 1.890

10.  Genetic control of interindividual variations in the inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes.

Authors:  S A Atlas; E S Vesell; D W Nebert
Journal:  Cancer Res       Date:  1976-12       Impact factor: 12.701
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  2 in total

1.  Acetanilide and paracetamol pharmacokinetics before and during phenytoin administration: genetic control of induction?

Authors:  J L Cunningham; D A Evans
Journal:  Br J Clin Pharmacol       Date:  1981-01       Impact factor: 4.335

2.  Enhanced benzo(a)pyrene metabolism and formation of DNA adducts in monocytes of patients with lung cancer.

Authors:  H W Rüdiger; V Heisig; E Hain
Journal:  J Cancer Res Clin Oncol       Date:  1980       Impact factor: 4.553
  2 in total

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