Literature DB >> 4815724

Benzo(a)pyrene metabolites: efficient and rapid separation by high-pressure liquid chromatography.

J K Selkirk, R G Croy, H V Gelboin.   

Abstract

High-pressure liquid chromatography can separate eight metabolites of benzo[a] pyrene formed by rat liver microsomes. This method offers major advantages over previous techniques used for the separation of oxygenated polycyclic aromatic hydrocarbons.

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Year:  1974        PMID： 4815724     DOI： 10.1126/science.184.4133.169

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  19 in total

1.  Photoproducts from DNA pyrimidine bases and polycyclic aromatic hydrocarbons.

Authors:  G M Blackburn; R G Fenwick; G Lockwood; G M Williams
Journal:  Nucleic Acids Res       Date:  1977-07       Impact factor: 16.971

2.  Rates of microbial transformation of polycyclic aromatic hydrocarbons in water and sediments in the vicinity of a coal-coking wastewater discharge.

Authors:  S E Herbes
Journal:  Appl Environ Microbiol       Date:  1981-01       Impact factor: 4.792

3.  In vitro metabolism and in vivo binding of benzo(a)pyrene in the California killifish (Fundulus parvipinnis) and speckled sanddab (Citharicthys stigmaeous).

Authors:  E von Hofe; H W Puffer
Journal:  Arch Environ Contam Toxicol       Date:  1986-05       Impact factor: 2.804

4.  Birth defects and aplastic anemia: differences in polycyclic hydrocarbon toxicity associated with the Ah locus.

Authors:  D W Nebert; R C Levitt; N M Jensen; G H Lambert; J S Felton
Journal:  Arch Toxicol       Date:  1977-12-30       Impact factor: 5.153

5.  Activation of xenobiotics by monooxygenases: cultures of mammalian cells as analytical tool.

Authors:  F J Wiebel; S Brown; H L Waters; J K Selkirk
Journal:  Arch Toxicol       Date:  1977-12-30       Impact factor: 5.153

6.  Influence of herpes simplex virus infection on benzo(a)pyrene metabolism in monkey kidney cells.

Authors:  J H Degenhardt; B Whitcomb; M R Hall
Journal:  Bull Environ Contam Toxicol       Date:  1984-01       Impact factor: 2.151

7.  Identification of 7,12-dimethylbenz[a]anthracene metabolites that lead to mutagenesis in mammalian cells.

Authors:  E Huberman; M W Chou; S K Yang
Journal:  Proc Natl Acad Sci U S A       Date:  1979-02       Impact factor: 11.205

8.  Inducibility of aryl hydrocarbon hydroxylase in cultured human lymphocytes: a study of repeatability.

Authors:  K A Fletcher; D A Evans; M V Canning
Journal:  J Med Genet       Date:  1978-06       Impact factor: 6.318

9.  Effects of inducers and epoxide hydrase on the metabolism of benzo(a)pyrene by liver microsomes and a reconstituted system: analysis by high pressure liquid chromatography.

Authors:  G Holder; H Yagi; P Dansette; D M Jerina; W Levin; A Y Lu; A H Conney
Journal:  Proc Natl Acad Sci U S A       Date:  1974-11       Impact factor: 11.205

10.  Purification and characterization of liver cytochrome P-446 isolated from protein energy malnourished rats.

Authors:  L Gil; H Vasquez; M Orellana; J Selkirk; F Wold; H Strobel
Journal:  Mol Cell Biochem       Date:  1988-01       Impact factor: 3.396
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