Literature DB >> 35243530

Bone Turnover Markers in Children: From Laboratory Challenges to Clinical Interpretation.

Aurélie Ladang1, Frank Rauch2, Edgard Delvin3, Etienne Cavalier4.   

Abstract

Bone turnover markers (BTMs) have been developed many years ago to study, in combination with imaging techniques, bone remodeling in adults. In children and adolescents, bone metabolism differs from adults since it implies both growth and bone remodeling, suggesting an age- and gender-dependent BTM concentration. Therefore, specific studies have evaluated BTMs in not only physiological but also pathological conditions. However, in pediatrics, the use of BTMs in clinical practice is still limited due to these many children-related specificities. This review will discuss about physiological levels of BTMs as well as their modifications under pathological conditions in children and adolescents. A focus is also given on analytical and clinical challenges that restrain BTM usefulness in pediatrics.
© 2022. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

Entities:  

Keywords:  BALP; Bone turnover markers; CTX; Children; Osteoblasts; Osteoclasts; PINP; TRAP

Year:  2022        PMID： 35243530     DOI： 10.1007/s00223-022-00964-2

Source DB:  PubMed          Journal:  Calcif Tissue Int        ISSN： 0171-967X            Impact factor:   4.333


  126 in total

1.  Proposal for guidelines to establish common biological reference intervals in large geographical areas for biochemical quantities measured frequently in serum and plasma.

Authors:  Pål Rustad; Peter Felding; Ari Lahti
Journal:  Clin Chem Lab Med       Date:  2004       Impact factor: 3.694

2.  A multicenter study to evaluate harmonization of assays for N-terminal propeptide of type I procollagen (PINP): a report from the IFCC-IOF Joint Committee for Bone Metabolism.

Authors:  Etienne Cavalier; Richard Eastell; Niklas Rye Jørgensen; Konstantinos Makris; Symeon Tournis; Samuel Vasikaran; John A Kanis; Cyrus Cooper; Hans Pottel; Howard A Morris
Journal:  Clin Chem Lab Med       Date:  2019-09-25       Impact factor: 3.694

3.  Effect of fracture on bone turnover markers: a longitudinal study comparing marker levels before and after injury in 113 elderly women.

Authors:  Kaisa K Ivaska; Paul Gerdhem; Kristina Akesson; Patrick Garnero; Karl J Obrant
Journal:  J Bone Miner Res       Date:  2007-08       Impact factor: 6.741

4.  CLSI-based transference of the CALIPER database of pediatric reference intervals from Abbott to Beckman, Ortho, Roche and Siemens Clinical Chemistry Assays: direct validation using reference samples from the CALIPER cohort.

Authors:  Mathew P Estey; Ashley H Cohen; David A Colantonio; Man Khun Chan; Tina Binesh Marvasti; Edward Randell; Edgard Delvin; Jocelyne Cousineau; Vijaylaxmi Grey; Donald Greenway; Qing H Meng; Benjamin Jung; Jalaluddin Bhuiyan; David Seccombe; Khosrow Adeli
Journal:  Clin Biochem       Date:  2013-04-08       Impact factor: 3.281

5.  Interpretation of biomarkers of bone metabolism in children: impact of growth velocity and body size in healthy children and chronic disease.

Authors:  Shamir Tuchman; Meena Thayu; Justine Shults; Babette S Zemel; Jon M Burnham; Mary B Leonard
Journal:  J Pediatr       Date:  2008-06-16       Impact factor: 4.406

6.  National Bone Health Alliance Bone Turnover Marker Project: current practices and the need for US harmonization, standardization, and common reference ranges.

Authors:  D Bauer; J Krege; N Lane; E Leary; C Libanati; P Miller; G Myers; S Silverman; H W Vesper; D Lee; M Payette; S Randall
Journal:  Osteoporos Int       Date:  2012-07-14       Impact factor: 4.507

7.  Bone evaluation in paediatric chronic kidney disease: clinical practice points from the European Society for Paediatric Nephrology CKD-MBD and Dialysis working groups and CKD-MBD working group of the ERA-EDTA.

Authors:  Sevcan A Bakkaloglu; Justine Bacchetta; Alexander D Lalayiannis; Maren Leifheit-Nestler; Stella Stabouli; Mathias Haarhaus; George Reusz; Jaap Groothoff; Claus Peter Schmitt; Pieter Evenepoel; Rukshana Shroff; Dieter Haffner
Journal:  Nephrol Dial Transplant       Date:  2021-02-20       Impact factor: 5.992

8.  Reference values of osteocalcin and procollagen type I N-propeptide plasma levels in a healthy Central European population aged 0-18 years.

Authors:  M Bayer
Journal:  Osteoporos Int       Date:  2013-08-22       Impact factor: 4.507

9.  International Osteoporosis Foundation and International Federation of Clinical Chemistry and Laboratory Medicine position on bone marker standards in osteoporosis.

Authors:  Samuel Vasikaran; Cyrus Cooper; Richard Eastell; Andrea Griesmacher; Howard A Morris; Tommaso Trenti; John A Kanis
Journal:  Clin Chem Lab Med       Date:  2011-05-24       Impact factor: 3.694

Review 10.  Advances in Pediatric Reference Intervals for Biochemical Markers: Establishment of the Caliper Database in Healthy Children and Adolescents.

Authors:  Kimiya Karbasy; Petra Ariadne; Stephanie Gaglione; Michelle Nieuwesteeg; Khosrow Adeli
Journal:  J Med Biochem       Date:  2014-10-08       Impact factor: 3.402
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