OBJECTIVES: To determine the effects of growth, maturation, and whole body bone mineral content (WB-BMC) accrual on biomarkers of bone formation (bone-specific alkaline phosphatase [BSAP]) and resorption (urine deoxypyridinoline/creatinine [DPD]) in healthy children and children with Crohn's disease. STUDY DESIGN: BSAP and DPD were measured at baseline, with growth and dual energy x-ray absorptiometry (DXA) WB-BMC measured at baseline and 6 months in 202 control subjects and 110 subjects with Crohn's disease, ages 5 to 21 years. Multivariable linear regression identified determinants of biomarkers in control subjects and subjects with Crohn's disease. RESULTS: In control subjects, BSAP and DPD were significantly and independently associated with sex, Tanner stage, WB-BMC, height velocity, and WB-BMC accrual rates; these covariates explained 77% to 80% of the variability in the bone biomarkers, respectively. Subjects with Crohn's disease had lower height-for-age (P < .001) and WB-BMC-for-height (P <.05) than control subjects. Crohn's disease was associated with lower BSAP (P < .001) and greater DPD (P < .001), independent of growth, maturation, baseline WB-BMC, and WB-BMC accrual, compared with control subjects. CONCLUSIONS: These data illustrate the potential confounding effects of growth and WB-BMC on bone metabolism biomarkers in children. After adjustment for these effects, Crohn's disease was associated with lower biomarkers of bone formation and greater bone resorption.
OBJECTIVES: To determine the effects of growth, maturation, and whole body bone mineral content (WB-BMC) accrual on biomarkers of bone formation (bone-specific alkaline phosphatase [BSAP]) and resorption (urine deoxypyridinoline/creatinine [DPD]) in healthy children and children with Crohn's disease. STUDY DESIGN:BSAP and DPD were measured at baseline, with growth and dual energy x-ray absorptiometry (DXA) WB-BMC measured at baseline and 6 months in 202 control subjects and 110 subjects with Crohn's disease, ages 5 to 21 years. Multivariable linear regression identified determinants of biomarkers in control subjects and subjects with Crohn's disease. RESULTS: In control subjects, BSAP and DPD were significantly and independently associated with sex, Tanner stage, WB-BMC, height velocity, and WB-BMC accrual rates; these covariates explained 77% to 80% of the variability in the bone biomarkers, respectively. Subjects with Crohn's disease had lower height-for-age (P < .001) and WB-BMC-for-height (P <.05) than control subjects. Crohn's disease was associated with lower BSAP (P < .001) and greater DPD (P < .001), independent of growth, maturation, baseline WB-BMC, and WB-BMC accrual, compared with control subjects. CONCLUSIONS: These data illustrate the potential confounding effects of growth and WB-BMC on bone metabolism biomarkers in children. After adjustment for these effects, Crohn's disease was associated with lower biomarkers of bone formation and greater bone resorption.
Authors: Francisco A Sylvester; Nancy Wyzga; Jeffrey S Hyams; Patricia M Davis; Trudy Lerer; Katherine Vance; Gillian Hawker; Anne M Griffiths Journal: Inflamm Bowel Dis Date: 2007-01 Impact factor: 5.325
Authors: H Tobiume; S Kanzaki; S Hida; T Ono; T Moriwake; S Yamauchi; H Tanaka; Y Seino Journal: J Clin Endocrinol Metab Date: 1997-07 Impact factor: 5.958
Authors: Markus Rauchenzauner; Andrea Schmid; Peter Heinz-Erian; Klaus Kapelari; Gerda Falkensammer; Andrea Griesmacher; Gerd Finkenstedt; Wolfgang Högler Journal: J Clin Endocrinol Metab Date: 2006-11-14 Impact factor: 5.958
Authors: Meena Thayu; Justine Shults; Jon M Burnham; Babette S Zemel; Robert N Baldassano; Mary B Leonard Journal: Inflamm Bowel Dis Date: 2007-09 Impact factor: 5.325
Authors: Helen M Pappa; Tracee M Saslowsky; Rajna Filip-Dhima; Diane DiFabio; Hajar Hassani Lahsinoui; Apurva Akkad; Richard J Grand; Catherine M Gordon Journal: Am J Gastroenterol Date: 2011-04-26 Impact factor: 10.864
Authors: Anniek M Terpstra; Heidi J Kalkwarf; Justine Shults; Babette S Zemel; Rachel J Wetzsteon; Bethany J Foster; C Frederic Strife; Debbie L Foerster; Mary B Leonard Journal: J Am Soc Nephrol Date: 2012-01-26 Impact factor: 10.121
Authors: Heidi V Russell; Susan G Groshen; Tasnim Ara; Yves A DeClerck; Randy Hawkins; Hollie A Jackson; Heike E Daldrup-Link; Araz Marachelian; Andrej Skerjanec; Julie R Park; Howard Katzenstein; Katherine K Matthay; Susan M Blaney; Judith G Villablanca Journal: Pediatr Blood Cancer Date: 2010-11-12 Impact factor: 3.167
Authors: Ellen B Fung; Elliott P Vichinsky; Janet L Kwiatkowski; James Huang; Laura K Bachrach; Aenor J Sawyer; Babette S Zemel Journal: Bone Date: 2011-04-05 Impact factor: 4.398
Authors: Lindsay M Griffin; Meena Thayu; Robert N Baldassano; Mark D DeBoer; Babette S Zemel; Michelle R Denburg; Lee A Denson; Justine Shults; Rita Herskovitz; Jin Long; Mary B Leonard Journal: J Clin Endocrinol Metab Date: 2015-04-28 Impact factor: 5.958
Authors: Kylie E Whitten; Steven T Leach; Timothy D Bohane; Helen J Woodhead; Andrew S Day Journal: J Gastroenterol Date: 2009-12-03 Impact factor: 7.527
Authors: Anne Tsampalieros; Pooja Gupta; Michelle R Denburg; Justine Shults; Babette S Zemel; Sogol Mostoufi-Moab; Rachel J Wetzsteon; Rita M Herskovitz; Krista M Whitehead; Mary B Leonard Journal: J Bone Miner Res Date: 2013-03 Impact factor: 6.741