| Literature DB >> 35115690 |
Esteban A Lopera-Maya1, Alexander Kurilshikov1, Adriaan van der Graaf1, Shixian Hu1,2, Sergio Andreu-Sánchez1,3, Lianmin Chen1,3, Arnau Vich Vila1,2, Ranko Gacesa1,2, Trishla Sinha2, Valerie Collij1,2, Marjiolein A Y Klaassen1,2, Laura A Bolte1,2, Milla F Brandao Gois1, Pieter B T Neerincx1,4, Morris A Swertz1,4, Hermie J M Harmsen5, Cisca Wijmenga1, Jingyuan Fu1,3, Rinse K Weersma2, Alexandra Zhernakova6, Serena Sanna7,8.
Abstract
Host genetics are known to influence the gut microbiome, yet their role remains poorly understood. To robustly characterize these effects, we performed a genome-wide association study of 207 taxa and 205 pathways representing microbial composition and function in 7,738 participants of the Dutch Microbiome Project. Two robust, study-wide significant (P < 1.89 × 10-10) signals near the LCT and ABO genes were found to be associated with multiple microbial taxa and pathways and were replicated in two independent cohorts. The LCT locus associations seemed modulated by lactose intake, whereas those at ABO could be explained by participant secretor status determined by their FUT2 genotype. Twenty-two other loci showed suggestive evidence (P < 5 × 10-8) of association with microbial taxa and pathways. At a more lenient threshold, the number of loci we identified strongly correlated with trait heritability, suggesting that much larger sample sizes are needed to elucidate the remaining effects of host genetics on the gut microbiome.Entities:
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Year: 2022 PMID： 35115690 DOI： 10.1038/s41588-021-00992-y
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 41.307