| Literature DB >> 27126039 |
Gwen Falony1, Marie Joossens2, Sara Vieira-Silva1, Jun Wang1, Youssef Darzi2, Karoline Faust2, Alexander Kurilshikov3, Marc Jan Bonder4, Mireia Valles-Colomer1, Doris Vandeputte2, Raul Y Tito2, Samuel Chaffron2, Leen Rymenans2, Chloë Verspecht1, Lise De Sutter2, Gipsi Lima-Mendez1, Kevin D'hoe2, Karl Jonckheere5, Daniel Homola5, Roberto Garcia5, Ettje F Tigchelaar6, Linda Eeckhaudt5, Jingyuan Fu7, Liesbet Henckaerts8, Alexandra Zhernakova6, Cisca Wijmenga4, Jeroen Raes9.
Abstract
Fecal microbiome variation in the average, healthy population has remained under-investigated. Here, we analyzed two independent, extensively phenotyped cohorts: the Belgian Flemish Gut Flora Project (FGFP; discovery cohort; N = 1106) and the Dutch LifeLines-DEEP study (LLDeep; replication; N = 1135). Integration with global data sets (N combined = 3948) revealed a 14-genera core microbiota, but the 664 identified genera still underexplore total gut diversity. Sixty-nine clinical and questionnaire-based covariates were found associated to microbiota compositional variation with a 92% replication rate. Stool consistency showed the largest effect size, whereas medication explained largest total variance and interacted with other covariate-microbiota associations. Early-life events such as birth mode were not reflected in adult microbiota composition. Finally, we found that proposed disease marker genera associated to host covariates, urging inclusion of the latter in study design.Entities:
Mesh：
Year: 2016 PMID： 27126039 DOI： 10.1126/science.aad3503
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728