| Literature DB >> 29489753 |
Daphna Rothschild1,2, Omer Weissbrod1,2, Elad Barkan1,2, Alexander Kurilshikov3, Tal Korem1,2, David Zeevi1,2, Paul I Costea1,2, Anastasia Godneva1,2, Iris N Kalka1,2, Noam Bar1,2, Smadar Shilo1,2, Dar Lador1,2, Arnau Vich Vila3,4, Niv Zmora5,6,7, Meirav Pevsner-Fischer5, David Israeli8, Noa Kosower1,2, Gal Malka1,2, Bat Chen Wolf1,2, Tali Avnit-Sagi1,2, Maya Lotan-Pompan1,2, Adina Weinberger1,2, Zamir Halpern7,9, Shai Carmi10, Jingyuan Fu3,11, Cisca Wijmenga3,12, Alexandra Zhernakova3, Eran Elinav5, Eran Segal1,2.
Abstract
Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds.Entities:
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Year: 2018 PMID： 29489753 DOI： 10.1038/nature25973
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962