| Literature DB >> 27126040 |
Alexandra Zhernakova1, Alexander Kurilshikov2, Marc Jan Bonder3, Ettje F Tigchelaar4, Melanie Schirmer5, Tommi Vatanen6, Zlatan Mujagic7, Arnau Vich Vila8, Gwen Falony9, Sara Vieira-Silva9, Jun Wang9, Floris Imhann8, Eelke Brandsma10, Soesma A Jankipersadsing3, Marie Joossens11, Maria Carmen Cenit12, Patrick Deelen13, Morris A Swertz13, Rinse K Weersma8, Edith J M Feskens14, Mihai G Netea15, Dirk Gevers16, Daisy Jonkers17, Lude Franke3, Yurii S Aulchenko18, Curtis Huttenhower5, Jeroen Raes11, Marten H Hofker10, Ramnik J Xavier19, Cisca Wijmenga20, Jingyuan Fu21.
Abstract
Deep sequencing of the gut microbiomes of 1135 participants from a Dutch population-based cohort shows relations between the microbiome and 126 exogenous and intrinsic host factors, including 31 intrinsic factors, 12 diseases, 19 drug groups, 4 smoking categories, and 60 dietary factors. These factors collectively explain 18.7% of the variation seen in the interindividual distance of microbial composition. We could associate 110 factors to 125 species and observed that fecal chromogranin A (CgA), a protein secreted by enteroendocrine cells, was exclusively associated with 61 microbial species whose abundance collectively accounted for 53% of microbial composition. Low CgA concentrations were seen in individuals with a more diverse microbiome. These results are an important step toward a better understanding of environment-diet-microbe-host interactions.Entities:
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Year: 2016 PMID： 27126040 PMCID： PMC5240844 DOI： 10.1126/science.aad3369
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728