Literature DB >> 3500042

The human alpha 1-antitrypsin gene is transcribed from two different promoters in macrophages and hepatocytes.

E Perlino1, R Cortese, G Ciliberto.   

Abstract

In order to investigate the mechanism of expression of the human alpha 1-antitrypsin (alpha 1-AT) gene in macrophages, we have characterized the alpha 1-AT transcriptional units in these cells and discovered that there is a macrophage-specific promoter located approximately 2000 bp upstream of the hepatocyte-specific promoter. Transcription from the two alpha 1-AT promoters is mutually exclusive: the macrophage promoter is silent in hepatocytes and the hepatocyte promoter is silent in macrophages. In addition, in macrophages two distinct mRNAs are generated transcript by alternative splicing. These results suggest that alpha 1-AT gene transcription responds to two different cell-specific regulatory mechanisms.

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Year:  1987        PMID： 3500042      PMCID： PMC553701          DOI： 10.1002/j.1460-2075.1987.tb02571.x

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  34 in total

1.  Sizing and mapping of early adenovirus mRNAs by gel electrophoresis of S1 endonuclease-digested hybrids.

Authors:  A J Berk; P A Sharp
Journal:  Cell       Date:  1977-11       Impact factor: 41.582

Review 2.  Synthesis and secretion of complement proteins by macrophages.

Authors:  H R Colten; Y M Ooi; P J Edelson
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3.  Multiple upstream AUG codons mediate translational control of GCN4.

Authors:  P P Mueller; A G Hinnebusch
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4.  Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain.

Authors:  J Rogers; P Early; C Carter; K Calame; M Bond; L Hood; R Wall
Journal:  Cell       Date:  1980-06       Impact factor: 41.582

5.  Studies of hepatic synthesis in vivo of plasma proteins, including orosomucoid, transferrin, alpha 1-antitrypsin, C8, and factor B.

Authors:  C A Alper; D Raum; Z L Awdeh; B H Petersen; P D Taylor; T E Starzl
Journal:  Clin Immunol Immunopathol       Date:  1980-05

Review 6.  Alpha1-antitrypsin and its deficiency.

Authors:  F Kueppers; L F Black
Journal:  Am Rev Respir Dis       Date:  1974-08

Review 7.  The current status of alpha-1-antityrpsin, a protease inhibitor, in gastrointestinal disease.

Authors:  H L Sharp
Journal:  Gastroenterology       Date:  1976-04       Impact factor: 22.682

8.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

9.  Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease.

Authors:  J M Chirgwin; A E Przybyla; R J MacDonald; W J Rutter
Journal:  Biochemistry       Date:  1979-11-27       Impact factor: 3.162

10.  Cloning of several cDNA segments coding for human liver proteins.

Authors:  F Costanzo; L Castagnoli; L Dente; P Arcari; M Smith; P Costanzo; G Raugei; P Izzo; T C Pietropaolo; L Bougueleret; F Cimino; F Salvatore; R Cortese
Journal:  EMBO J       Date:  1983       Impact factor: 11.598
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  56 in total

1.  Chromosomal elements regulate gene activity and chromatin structure of the human serpin gene cluster at 14q32.1.

Authors:  Mark D Marsden; R E K Fournier
Journal:  Mol Cell Biol       Date:  2003-05       Impact factor: 4.272

Review 2.  Molecular biology and respiratory disease. 7. The alpha 1 antitrypsin gene and chronic lung disease.

Authors:  N Kalsheker; K Morgan
Journal:  Thorax       Date:  1990-10       Impact factor: 9.139

3.  Differential transcription of exon 1 of the human c-fms gene in placental trophoblasts and monocytes.

Authors:  J Visvader; I M Verma
Journal:  Mol Cell Biol       Date:  1989-03       Impact factor: 4.272

4.  Characterization of the gene and protein of the common alpha 1-antitrypsin normal M2 allele.

Authors:  T Nukiwa; M L Brantly; F Ogushi; G A Fells; R G Crystal
Journal:  Am J Hum Genet       Date:  1988-09       Impact factor: 11.025

5.  Alpha 1-antitrypsin deficiency caused by the alpha 1-antitrypsin Nullmattawa gene. An insertion mutation rendering the alpha 1-antitrypsin gene incapable of producing alpha 1-antitrypsin.

Authors:  D Curiel; M Brantly; E Curiel; L Stier; R G Crystal
Journal:  J Clin Invest       Date:  1989-04       Impact factor: 14.808

6.  Characterization of the normal alpha 1-antitrypsin allele Vmunich: a variant associated with a unique protein isoelectric focusing pattern.

Authors:  M D Holmes; M L Brantly; D T Curiel; S Weidinger; R G Crystal
Journal:  Am J Hum Genet       Date:  1990-04       Impact factor: 11.025

7.  Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes.

Authors:  R H Costa; D R Grayson; J E Darnell
Journal:  Mol Cell Biol       Date:  1989-04       Impact factor: 4.272

8.  In-frame single codon deletion in the Mmalton deficiency allele of alpha 1-antitrypsin.

Authors:  G C Fraizer; T R Harrold; M H Hofker; D W Cox
Journal:  Am J Hum Genet       Date:  1989-06       Impact factor: 11.025

9.  Multiple hepatic trans-acting factors are required for in vitro transcription of the human alpha-1-antitrypsin gene.

Authors:  Y Li; R F Shen; S Y Tsai; S L Woo
Journal:  Mol Cell Biol       Date:  1988-10       Impact factor: 4.272

10.  Local extrahepatic expression of complement genes C3, factor B, C2, and C4 is increased in murine lupus nephritis.

Authors:  J Passwell; G F Schreiner; M Nonaka; H U Beuscher; H R Colten
Journal:  J Clin Invest       Date:  1988-11       Impact factor: 14.808
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