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Literature DB >> 3477805

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

M W Hentze¹, T A Rouault, S W Caughman, A Dancis, J B Harford, R D Klausner.

Abstract

Ferritin plays a key role in determining the intracellular fate of iron and is highly regulated by the iron status of the cell. We have identified a cis-acting element in the transcribed but nontranslated 5' leader sequence of human ferritin heavy-chain mRNA. In transiently transfected murine fibroblasts, the presence of a 157-nucleotide region of the 5' leader sequence was found to be necessary for iron-dependent regulation of ferritin biosynthesis. Further, this 5' leader region is sufficient to transfer iron-mediated translational control to the expression of a heterologous gene product, chloramphenicol acetyltransferase.

Entities: Chemical Gene Species

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Year: 1987 PMID： 3477805 PMCID： PMC299157 DOI： 10.1073/pnas.84.19.6730

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

27 in total

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70 in total

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