Literature DB >> 9207027

Location of the internal ribosome entry site in the 5' non-coding region of the immunoglobulin heavy-chain binding protein (BiP) mRNA: evidence for specific RNA-protein interactions.

Q Yang1, P Sarnow.   

Abstract

The 220 nucleotide 5'non-coding region (5'NCR) of the human immunoglobulin heavy chain binding protein (BiP) mRNA contains an internal ribosome entry site (IRES) that mediates the translation of the second cistron in a dicistronic mRNA in cultured mammalian cells. In this study, experiments are presented that locate the IRES immediately upstream of the start-site AUG codon in the BiP mRNA. Furthermore, crosslinking of thiouridine-labeled BiP IRES-containing RNA to cellular proteins identified the specific binding of two proteins, p60 and p95, to the 3'half of the BiP 5'NCR. Interestingly, both p60 and p95 bound also specifically to several viral IRES elements. This correlation suggests that p60 and p95 could have roles in internal initiation of cellular and viral IRES elements.

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Year:  1997        PMID： 9207027      PMCID： PMC146825          DOI： 10.1093/nar/25.14.2800

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  43 in total

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Authors:  D G Macejak; P Sarnow
Journal:  Nature       Date:  1991-09-05       Impact factor: 49.962

2.  Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.

Authors:  J G Patton; S A Mayer; P Tempst; B Nadal-Ginard
Journal:  Genes Dev       Date:  1991-07       Impact factor: 11.361

3.  Initiation of protein synthesis by the eukaryotic translational apparatus on circular RNAs.

Authors:  C Y Chen; P Sarnow
Journal:  Science       Date:  1995-04-21       Impact factor: 47.728

4.  Precipitation techniques.

Authors:  S Englard; S Seifter
Journal:  Methods Enzymol       Date:  1990       Impact factor: 1.600

Review 5.  Cap-dependent and cap-independent translation: operational distinctions and mechanistic interpretations.

Authors:  R J Jackson; S L Hunt; J E Reynolds; A Kaminski
Journal:  Curr Top Microbiol Immunol       Date:  1995       Impact factor: 4.291

Review 6.  Translational control by iron-responsive elements.

Authors:  M W Hentze
Journal:  Adv Exp Med Biol       Date:  1994       Impact factor: 2.622

7.  Proteolytic cleavage of initiation factor eIF-4 gamma in the reticulocyte lysate inhibits translation of capped mRNAs but enhances that of uncapped mRNAs.

Authors:  T Ohlmann; M Rau; S J Morley; V M Pain
Journal:  Nucleic Acids Res       Date:  1995-02-11       Impact factor: 16.971

8.  Unusual folding regions and ribosome landing pad within hepatitis C virus and pestivirus RNAs.

Authors:  S Y Le; N Sonenberg; J V Maizel
Journal:  Gene       Date:  1995-03-10       Impact factor: 3.688

9.  Mapping of functional domains in eukaryotic protein synthesis initiation factor 4G (eIF4G) with picornaviral proteases. Implications for cap-dependent and cap-independent translational initiation.

Authors:  B J Lamphear; R Kirchweger; T Skern; R E Rhoads
Journal:  J Biol Chem       Date:  1995-09-15       Impact factor: 5.157

10.  Alternative translation of human fibroblast growth factor 2 mRNA occurs by internal entry of ribosomes.

Authors:  S Vagner; M C Gensac; A Maret; F Bayard; F Amalric; H Prats; A C Prats
Journal:  Mol Cell Biol       Date:  1995-01       Impact factor: 4.272
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  43 in total

1.  Novel fluorescence-based screen to identify small synthetic internal ribosome entry site elements.

Authors:  A Venkatesan; A Dasgupta
Journal:  Mol Cell Biol       Date:  2001-04       Impact factor: 4.272

2.  A 9-nt segment of a cellular mRNA can function as an internal ribosome entry site (IRES) and when present in linked multiple copies greatly enhances IRES activity.

Authors:  S A Chappell; G M Edelman; V P Mauro
Journal:  Proc Natl Acad Sci U S A       Date:  2000-02-15       Impact factor: 11.205

3.  Identification of two short internal ribosome entry sites selected from libraries of random oligonucleotides.

Authors:  G C Owens; S A Chappell; V P Mauro; G M Edelman
Journal:  Proc Natl Acad Sci U S A       Date:  2001-02-13       Impact factor: 11.205

4.  New ways of initiating translation in eukaryotes.

Authors:  R Schneider; V I Agol; R Andino; F Bayard; D R Cavener; S A Chappell; J J Chen; J L Darlix; A Dasgupta; O Donzé; R Duncan; O Elroy-Stein; P J Farabaugh; W Filipowicz; M Gale; L Gehrke; E Goldman; Y Groner; J B Harford; M Hatzglou; B He; C U Hellen; M W Hentze; J Hershey; P Hershey; T Hohn; M Holcik; C P Hunter; K Igarashi; R Jackson; R Jagus; L S Jefferson; B Joshi; R Kaempfer; M Katze; R J Kaufman; M Kiledjian; S R Kimball; A Kimchi; K Kirkegaard; A E Koromilas; R M Krug; V Kruys; B J Lamphear; S Lemon; R E Lloyd; L E Maquat; E Martinez-Salas; M B Mathews; V P Mauro; S Miyamoto; I Mohr; D R Morris; E G Moss; N Nakashima; A Palmenberg; N T Parkin; T Pe'ery; J Pelletier; S Peltz; T V Pestova; E V Pilipenko; A C Prats; V Racaniello; G S Read; R E Rhoads; J D Richter; R Rivera-Pomar; T Rouault; A Sachs; P Sarnow; G C Scheper; L Schiff; D R Schoenberg; B L Semler; A Siddiqui; T Skern; N Sonenberg; W Sossin; N Standart; S M Tahara; A A Thomas; J J Toulmé; J Wilusz; E Wimmer; G Witherell; M Wormington
Journal:  Mol Cell Biol       Date:  2001-12       Impact factor: 4.272

5.  La autoantigen enhances translation of BiP mRNA.

Authors:  Y K Kim; S H Back; J Rho; S H Lee; S K Jang
Journal:  Nucleic Acids Res       Date:  2001-12-15       Impact factor: 16.971

6.  Human cytomegalovirus induces the endoplasmic reticulum chaperone BiP through increased transcription and activation of translation by using the BiP internal ribosome entry site.

Authors:  Nicholas J Buchkovich; Yongjun Yu; Francis J Pierciey; James C Alwine
Journal:  J Virol       Date:  2010-08-25       Impact factor: 5.103

7.  Analysis of the c-myc IRES; a potential role for cell-type specific trans-acting factors and the nuclear compartment.

Authors:  M Stoneley; T Subkhankulova; J P Le Quesne; M J Coldwell; C L Jopling; G J Belsham; A E Willis
Journal:  Nucleic Acids Res       Date:  2000-02-01       Impact factor: 16.971

8.  Mesencephalic astrocyte-derived neurotrophic factor is an ER-resident chaperone that protects against reductive stress in the heart.

Authors:  Adrian Arrieta; Erik A Blackwood; Winston T Stauffer; Michelle Santo Domingo; Alina S Bilal; Donna J Thuerauf; Amber N Pentoney; Cathrine Aivati; Anup V Sarakki; Shirin Doroudgar; Christopher C Glembotski
Journal:  J Biol Chem       Date:  2020-04-23       Impact factor: 5.157

9.  BiP internal ribosomal entry site activity is controlled by heat-induced interaction of NSAP1.

Authors:  Sungchan Cho; Sung Mi Park; Tae Don Kim; Jong Heon Kim; Kyong-Tai Kim; Sung Key Jang
Journal:  Mol Cell Biol       Date:  2006-10-30       Impact factor: 4.272

10.  Splicing mediates the activity of four putative cellular internal ribosome entry sites.

Authors:  Brian T Baranick; Nathan A Lemp; Jill Nagashima; Kei Hiraoka; Noriyuki Kasahara; Christopher R Logg
Journal:  Proc Natl Acad Sci U S A       Date:  2008-03-07       Impact factor: 11.205
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