| Literature DB >> 34708871 |
Samantha Plate1,2, Lisa Yankowitz1,3, Leslie Resorla4, Meghan R Swanson5, Shoba Sreenath Meera6, Annette Estes7, Natasha Marrus8, Meredith Cola1, Victoria Petrulla1, Aubrey Faggen1, Juhi Pandey1,9, Sarah Paterson10, John R Pruett8, Heather Hazlett11, Stephen Dager7, Tanya St John7, Kelly Botteron8, Lonnie Zwaigenbaum12, Joseph Piven11, Robert T Schultz1,9, Julia Parish-Morris1,9.
Abstract
Infant vocalizations are early-emerging communicative markers shown to be atypical in autism spectrum disorder (ASD), but few longitudinal, prospective studies exist. In this study, 23,850 infant vocalizations from infants at low (LR)- and high (HR)-risk for ASD (HR-ASD = 23, female = 3; HR-Neg = 35, female = 13; LR = 32, female = 10; 80% White; collected from 2007 to 2017 near Philadelphia) were analyzed at 6, 12, and 24 months. At 12 months, HR-ASD infants produced fewer vocalizations than HR-Neg infants. From 6 to 24 months, HR-Neg infants demonstrated steeper vocalization growth compared to HR-ASD and LR infants. Finally, among HR infants, vocalizing at 12 months was associated with language, social phenotype, and diagnosis at age 2. Infant vocalizing is an objective behavioral marker that could facilitate earlier detection of ASD.Entities:
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Year: 2021 PMID： 34708871 PMCID： PMC9112828 DOI： 10.1111/cdev.13697
Source DB: PubMed Journal: Child Dev ISSN： 0009-3920