Literature DB >> 3467586

Further data supporting linkage between cystic fibrosis and the met oncogene and haplotype analysis with met and pJ3.11.

M Farrall, E Watson, G Bates, G Bell, J Bell, K A Davies, X Estivill, H Kruyer, H Y Law, N Lench.   

Abstract

The linkage of cystic fibrosis (CF) and the polymorphic DNA markers pJ3.11, met, 7C22, DOCR1-917, COL1A2, and TCRB have jointly localized the mutation causing CF to chromosome 7q2.1-3.1. We report further linkage data with two polymorphic markers at the met oncogene locus, pmetH and pmetD, which supports the tight linkage found by White et al. between CF and met. One family shows evidence for meiotic recombination between CF and met. Analysis of haplotypes in CF pedigrees collected for linkage studies combined with data from single affected families requesting prenatal diagnosis (Farrall et al., Lancet i:1402-1404, 1986) shows CF and met to be in linkage equilibrium in our population while pJ3.11-CF haplotypes show a deviation from the equilibrium frequencies.

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Year:  1986        PMID： 3467586      PMCID： PMC1684134     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  12 in total

1.  The analysis of multiple polymorphic loci on a single human chromosome to exclude linkage to inherited disease: cystic fibrosis and chromosome 4.

Authors:  M Farrall; P Scambler; P North; R Williamson
Journal:  Am J Hum Genet       Date:  1986-01       Impact factor: 11.025

2.  Isolation of a further anonymous informative DNA sequence from chromosome seven closely linked to cystic fibrosis.

Authors:  P J Scambler; B J Wainwright; E Watson; G Bates; G Bell; R Williamson; M Farrall
Journal:  Nucleic Acids Res       Date:  1986-03-11       Impact factor: 16.971

3.  Linkage of COL1A2 collagen gene to cystic fibrosis, and its clinical implications.

Authors:  P J Scambler; B J Wainwright; M Farrall; J Bell; P Stanier; N J Lench; G Bell; H Kruyer; F Ramirez; R Williamson
Journal:  Lancet       Date:  1985-11-30       Impact factor: 79.321

4.  Linkage studies between polymorphic markers on chromosome 4 and cystic fibrosis.

Authors:  P Scambler; T Robbins; C Gilliam; A Boylston; P Tippett; R Williamson; K E Davies
Journal:  Hum Genet       Date:  1985       Impact factor: 4.132

5.  Linkage of cystic fibrosis to the pro alpha 2(I) collagen gene, COL1A2, on chromosome 7.

Authors:  M Buchwald; M Zsiga; D Markiewicz; N Plavsic; D Kennedy; S Zengerling; H F Willard; P Tsipouras; K Schmiegelow; M Schwartz
Journal:  Cytogenet Cell Genet       Date:  1986

6.  Defective beta adrenergic response of cystic fibrosis sweat glands in vivo and in vitro.

Authors:  K Sato; F Sato
Journal:  J Clin Invest       Date:  1984-06       Impact factor: 14.808

7.  A closely linked genetic marker for cystic fibrosis.

Authors:  R White; S Woodward; M Leppert; P O'Connell; M Hoff; J Herbst; J M Lalouel; M Dean; G Vande Woude
Journal:  Nature       Date:  1985 Nov 28-Dec 4       Impact factor: 49.962

8.  Strategies for multilocus linkage analysis in humans.

Authors:  G M Lathrop; J M Lalouel; C Julier; J Ott
Journal:  Proc Natl Acad Sci U S A       Date:  1984-06       Impact factor: 11.205

9.  Higher bioelectric potentials due to decreased chloride absorption in the sweat glands of patients with cystic fibrosis.

Authors:  P M Quinton; J Bijman
Journal:  N Engl J Med       Date:  1983-05-19       Impact factor: 91.245

10.  Localization of cystic fibrosis locus to human chromosome 7cen-q22.

Authors:  B J Wainwright; P J Scambler; J Schmidtke; E A Watson; H Y Law; M Farrall; H J Cooke; H Eiberg; R Williamson
Journal:  Nature       Date:  1985 Nov 28-Dec 4       Impact factor: 49.962
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  8 in total

Review 1.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M R Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 2.  Comparative map for mice and humans.

Authors:  J H Nadeau; M T Davisson; D P Doolittle; P Grant; A L Hillyard; M Kosowsky; T H Roderick
Journal:  Mamm Genome       Date:  1991       Impact factor: 2.957

3.  The role of genetic factors in the etiology of the affective disorders.

Authors:  S Hodgkinson; M J Mullan; H M Gurling
Journal:  Behav Genet       Date:  1990-03       Impact factor: 2.805

4.  Studies of RFLP closely linked to the cystic fibrosis locus throughout Europe lead to new considerations in populations genetics.

Authors:  J L Serre; B Simon-Bouy; E Mornet; B Jaume-Roig; A Balassopoulou; M Schwartz; A Taillandier; J Boué; A Boué
Journal:  Hum Genet       Date:  1990-04       Impact factor: 4.132

5.  Localization of the human multiple drug resistance gene, MDR1, to 7q21.1.

Authors:  D F Callen; E Baker; R N Simmers; R Seshadri; I B Roninson
Journal:  Hum Genet       Date:  1987-10       Impact factor: 4.132

6.  Cystic fibrosis.

Authors:  I Harwood; F Rosas; D K Edwards; J Kelso; W L Nyhan
Journal:  West J Med       Date:  1988-01

7.  Exclusion of catalytic and regulatory subunits of cAMP-dependent protein kinase as candidate genes for the defect causing cystic fibrosis.

Authors:  P Scambler; O Oyen; B Wainwright; M Farrall; H Y Law; X Estivill; M Sandberg; R Williamson; T Jahnsen
Journal:  Am J Hum Genet       Date:  1987-11       Impact factor: 11.025

8.  (C-A)n microsatellite repeat D7S522 is the most commonly deleted region in human primary breast cancer.

Authors:  J C Zenklusen; I Bièche; R Lidereau; C J Conti
Journal:  Proc Natl Acad Sci U S A       Date:  1994-12-06       Impact factor: 11.205
  8 in total

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