Literature DB >> 3011363

Linkage of cystic fibrosis to the pro alpha 2(I) collagen gene, COL1A2, on chromosome 7.

M Buchwald, M Zsiga, D Markiewicz, N Plavsic, D Kennedy, S Zengerling, H F Willard, P Tsipouras, K Schmiegelow, M Schwartz.   

Abstract

A linkage has been detected between the locus for cystic fibrosis (CF) and the pro alpha 2(I) collagen gene (COL1A2) which is located in the region q21.3----q22.1 of chromosome 7. Based on the combined linkage data derived from 50 informative two-generation nuclear families collected in Canada and Denmark, the distance between COL1A2 and CF is estimated to be 19 centiMorgans. Close linkage has also been detected between COL1A2 and the DNA marker D7S15 (formerly D0CRI-917) and the serum enzyme activity marker paraoxonase (PON), both of which have previously been found linked to CF. The results of the two-point and three-point linkage analyses indicate that the most probable order of these four genetic loci is COL1A2-D7S15 - PON - CF.

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Year:  1986        PMID： 3011363     DOI： 10.1159/000132235

Source DB:  PubMed          Journal:  Cytogenet Cell Genet        ISSN： 0301-0171


  12 in total

1.  Identification and regional localization of DNA markers on chromosome 7 for the cloning of the cystic fibrosis gene.

Authors:  J M Rommens; S Zengerling; J Burns; G Melmer; B S Kerem; N Plavsic; M Zsiga; D Kennedy; D Markiewicz; R Rozmahel
Journal:  Am J Hum Genet       Date:  1988-11       Impact factor: 11.025

2.  Linkage of cystic fibrosis to two tightly linked DNA markers: joint report from a collaborative study.

Authors:  A Beaudet; A Bowcock; M Buchwald; L Cavalli-Sforza; M Farrall; M C King; K Klinger; J M Lalouel; G Lathrop; S Naylor
Journal:  Am J Hum Genet       Date:  1986-12       Impact factor: 11.025

3.  Further data supporting linkage between cystic fibrosis and the met oncogene and haplotype analysis with met and pJ3.11.

Authors:  M Farrall; E Watson; G Bates; G Bell; J Bell; K A Davies; X Estivill; H Kruyer; H Y Law; N Lench
Journal:  Am J Hum Genet       Date:  1986-12       Impact factor: 11.025

4.  Genetic analysis of cystic fibrosis using linked DNA markers.

Authors:  L C Tsui; K Buetow; M Buchwald
Journal:  Am J Hum Genet       Date:  1986-12       Impact factor: 11.025

Review 5.  Genetic markers on chromosome 7.

Authors:  L C Tsui
Journal:  J Med Genet       Date:  1988-05       Impact factor: 6.318

Review 6.  Prenatal diagnosis of common genetic disorders.

Authors:  M D Crawfurd
Journal:  BMJ       Date:  1988 Aug 20-27

7.  Refined linkage map of chromosome 7 in the region of the cystic fibrosis gene.

Authors:  G M Lathrop; M Farrall; P O'Connell; B Wainwright; M Leppert; Y Nakamura; N Lench; H Kruyer; M Dean; M Park
Journal:  Am J Hum Genet       Date:  1988-01       Impact factor: 11.025

Review 8.  Diagnosis of genetic disease using recombinant DNA. Supplement.

Authors:  D N Cooper; J Schmidtke
Journal:  Hum Genet       Date:  1987-09       Impact factor: 4.132

9.  Mapping of DNA markers linked to the cystic fibrosis locus on the long arm of chromosome 7.

Authors:  S Zengerling; L C Tsui; K H Grzeschik; K Olek; J R Riordan; M Buchwald
Journal:  Am J Hum Genet       Date:  1987-03       Impact factor: 11.025

10.  Plasminogen activator inhibitor type 1 gene is located at region q21.3-q22 of chromosome 7 and genetically linked with cystic fibrosis.

Authors:  K W Klinger; R Winqvist; A Riccio; P A Andreasen; R Sartorio; L S Nielsen; N Stuart; P Stanislovitis; P Watkins; R Douglas
Journal:  Proc Natl Acad Sci U S A       Date:  1987-12       Impact factor: 11.205
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