Literature DB >> 3004205

The analysis of multiple polymorphic loci on a single human chromosome to exclude linkage to inherited disease: cystic fibrosis and chromosome 4.

M Farrall, P Scambler, P North, R Williamson.   

Abstract

Classical linkage programs analyze the segregation of two markers in informative families. When several markers are available for one human chromosome, pairwise analysis can exclude linkage between each marker and an inherited disease. The identification of restriction fragment length polymorphisms has made many new informative markers, assigned to chromosomes, available. We have adapted the multipoint linkage program MLINK developed by Lathrop et al. in order to exclude linkage between cystic fibrosis and several markers known to be on human chromosome 4. The exclusion obtained is greater than that for a pairwise analysis.

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Year:  1986        PMID： 3004205      PMCID： PMC1684714     

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  26 in total

1.  Sequential tests for the detection of linkage.

Authors:  N E MORTON
Journal:  Am J Hum Genet       Date:  1955-09       Impact factor: 11.025

2.  A search for linkage in cystic fibrosis.

Authors:  M C Goodchild; J H Edwards; K P Glenn; C Grindey; R Harris; P Mackintosh; J Wentzel
Journal:  J Med Genet       Date:  1976-12       Impact factor: 6.318

3.  The use of lod scores for the determination of the order of loci on a chromosome.

Authors:  E Sturt
Journal:  Ann Hum Genet       Date:  1975-10       Impact factor: 1.670

4.  A computer program for linkage analysis of general human pedigrees.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1976-09       Impact factor: 11.025

5.  Estimation of the recombination fraction in human pedigrees: efficient computation of the likelihood for human linkage studies.

Authors:  J Ott
Journal:  Am J Hum Genet       Date:  1974-09       Impact factor: 11.025

6.  An analysis procedure illustrated on a triple linkage of use for prenatal diagnosis of myotonic dystrophy.

Authors:  J H Renwick; D R Bolling
Journal:  J Med Genet       Date:  1971-12       Impact factor: 6.318

7.  An unusual human serum albumin variant: further data on genetic linkage between loci for human serum albumin and group-specific component (Ge).

Authors:  L R Weitkamp; E B Robson; D C Screffler; G Corney
Journal:  Am J Hum Genet       Date:  1968-07       Impact factor: 11.025

8.  Evolution of sickle variant gene.

Authors:  E Solomon; W F Bodmer
Journal:  Lancet       Date:  1979-04-28       Impact factor: 79.321

9.  Genetic linkage between structural loci for albumin and group specific component (Gc).

Authors:  L R Weitkamp; D L Rucknagel; H Gershowitz
Journal:  Am J Hum Genet       Date:  1966-11       Impact factor: 11.025

10.  A maximum likelihood map of chromosome 1.

Authors:  D C Rao; B J Keats; J M Lalouel; N E Morton; S Yee
Journal:  Am J Hum Genet       Date:  1979-11       Impact factor: 11.025
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  4 in total

1.  Further data supporting linkage between cystic fibrosis and the met oncogene and haplotype analysis with met and pJ3.11.

Authors:  M Farrall; E Watson; G Bates; G Bell; J Bell; K A Davies; X Estivill; H Kruyer; H Y Law; N Lench
Journal:  Am J Hum Genet       Date:  1986-12       Impact factor: 11.025

2.  A model system for the analysis of gene exclusion: cystic fibrosis and chromosome 19.

Authors:  B Wainwright; M Farrall; E Watson; R Williamson
Journal:  J Med Genet       Date:  1986-10       Impact factor: 6.318

Review 3.  Diagnosis of genetic disease using recombinant DNA. Supplement.

Authors:  D N Cooper; J Schmidtke
Journal:  Hum Genet       Date:  1987-09       Impact factor: 4.132

4.  An efficient strategy for gene mapping using multipoint linkage analysis: exclusion of the multiple endocrine neoplasia 2A (MEN2A) locus from chromosome 13.

Authors:  L A Farrer; P J Goodfellow; C M Lamarche; I Franjkovic; S Myers; B N White; J J Holden; J R Kidd; N E Simpson; K K Kidd
Journal:  Am J Hum Genet       Date:  1987-04       Impact factor: 11.025
  4 in total

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