| Literature DB >> 34516108 |
Wei Lin1, Gary C H Mo1, Sohum Mehta1, Jin Zhang1,2,3.
Abstract
Super-resolution activity imaging maps the biochemical architecture of living cells yet currently overlooks the locations of collaborating regulators/effectors. Building on the fluorescence fluctuation increase by contact (FLINC) principle, here we devise Dronpa-chromophore-removed FLINC (DrFLINC), where the nonfluorescent Dronpa can nevertheless enhance TagRFP-T fluorescence fluctuations. Exploiting DrFLINC, we develop a superior red label and a next-generation activity sensor for context-rich super-resolution biosensing.Entities:
Mesh：
Substances：
Year: 2021 PMID： 34516108 PMCID： PMC8575660 DOI： 10.1021/jacs.1c05530
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419