| Literature DB >> 34497388 |
Muzlifah Haniffa1,2,3, Deanne Taylor4,5, Sten Linnarsson6, Bruce J Aronow7, Gary D Bader8, Roger A Barker9,10, Pablo G Camara11, J Gray Camp12, Alain Chédotal13, Andrew Copp14, Heather C Etchevers15, Paolo Giacobini16, Berthold Göttgens9,17, Guoji Guo18, Ania Hupalowska19, Kylie R James20, Emily Kirby21, Arnold Kriegstein22, Joakim Lundeberg23, John C Marioni24, Kerstin B Meyer20, Kathy K Niakan25,26, Mats Nilsson27, Bayanne Olabi28, Dana Pe'er29, Aviv Regev19,30,31, Jennifer Rood19, Orit Rozenblatt-Rosen19,31, Rahul Satija32, Sarah A Teichmann20,33, Barbara Treutlein34, Roser Vento-Tormo20, Simone Webb28.
Abstract
The Human Developmental Cell Atlas (HDCA) initiative, which is part of the Human Cell Atlas, aims to create a comprehensive reference map of cells during development. This will be critical to understanding normal organogenesis, the effect of mutations, environmental factors and infectious agents on human development, congenital and childhood disorders, and the cellular basis of ageing, cancer and regenerative medicine. Here we outline the HDCA initiative and the challenges of mapping and modelling human development using state-of-the-art technologies to create a reference atlas across gestation. Similar to the Human Genome Project, the HDCA will integrate the output from a growing community of scientists who are mapping human development into a unified atlas. We describe the early milestones that have been achieved and the use of human stem-cell-derived cultures, organoids and animal models to inform the HDCA, especially for prenatal tissues that are hard to acquire. Finally, we provide a roadmap towards a complete atlas of human development.Entities:
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Year: 2021 PMID： 34497388 DOI： 10.1038/s41586-021-03620-1
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 69.504