| Literature DB >> 34400839 |
Julien Cohen-Adad1,2,3, Eva Alonso-Ortiz4, Mihael Abramovic5, Carina Arneitz5, Nicole Atcheson6, Laura Barlow7, Robert L Barry8,9,10, Markus Barth11, Marco Battiston12, Christian Büchel13, Matthew Budde14, Virginie Callot15,16, Anna J E Combes17, Benjamin De Leener18,19, Maxime Descoteaux20,21, Paulo Loureiro de Sousa22, Marek Dostál23, Julien Doyon24, Adam Dvorak25, Falk Eippert26, Karla R Epperson27, Kevin S Epperson27, Patrick Freund28, Jürgen Finsterbusch13, Alexandru Foias4, Michela Fratini29,30, Issei Fukunaga31, Claudia A M Gandini Wheeler-Kingshott12,32,33, Giancarlo Germani33, Guillaume Gilbert34, Federico Giove30,35, Charley Gros4,6, Francesco Grussu12,36, Akifumi Hagiwara31, Pierre-Gilles Henry37, Tomáš Horák38, Masaaki Hori39, James Joers37, Kouhei Kamiya40, Haleh Karbasforoushan41,42, Miloš Keřkovský23, Ali Khatibi24,43, Joo-Won Kim44, Nawal Kinany45,46, Hagen Kitzler47, Shannon Kolind7,25,48, Yazhuo Kong49,50,51, Petr Kudlička38, Paul Kuntke47, Nyoman D Kurniawan6, Slawomir Kusmia52,53,54, René Labounek55,56, Maria Marcella Laganà57, Cornelia Laule58, Christine S Law59, Christophe Lenglet37, Tobias Leutritz60, Yaou Liu61,62, Sara Llufriu63, Sean Mackey59, Eloy Martinez-Heras63, Loan Mattera64, Igor Nestrasil37,55, Kristin P O'Grady17,65, Nico Papinutto66, Daniel Papp4,51, Deborah Pareto67, Todd B Parrish41, Anna Pichiecchio32,33, Ferran Prados12,53,68, Àlex Rovira67, Marc J Ruitenberg69, Rebecca S Samson12, Giovanni Savini33, Maryam Seif28,60, Alan C Seifert44, Alex K Smith51, Seth A Smith17,65, Zachary A Smith70, Elisabeth Solana63, Yuichi Suzuki40, George Tackley52, Alexandra Tinnermann13, Jan Valošek71, Dimitri Van De Ville45,46, Marios C Yiannakas12, Kenneth A Weber59, Nikolaus Weiskopf60,72, Richard G Wise52,73, Patrik O Wyss5, Junqian Xu44.
Abstract
Quantitative spinal cord (SC) magnetic resonance imaging (MRI) presents many challenges, including a lack of standardized imaging protocols. Here we present a prospectively harmonized quantitative MRI protocol, which we refer to as the spine generic protocol, for users of 3T MRI systems from the three main manufacturers: GE, Philips and Siemens. The protocol provides guidance for assessing SC macrostructural and microstructural integrity: T1-weighted and T2-weighted imaging for SC cross-sectional area computation, multi-echo gradient echo for gray matter cross-sectional area, and magnetization transfer and diffusion weighted imaging for assessing white matter microstructure. In a companion paper from the same authors, the spine generic protocol was used to acquire data across 42 centers in 260 healthy subjects. The key details of the spine generic protocol are also available in an open-access document that can be found at https://github.com/spine-generic/protocols . The protocol will serve as a starting point for researchers and clinicians implementing new SC imaging initiatives so that, in the future, inclusion of the SC in neuroimaging protocols will be more common. The protocol could be implemented by any trained MR technician or by a researcher/clinician familiar with MRI acquisition.Entities:
Mesh：
Year: 2021 PMID： 34400839 PMCID： PMC8811488 DOI： 10.1038/s41596-021-00588-0
Source DB: PubMed Journal: Nat Protoc ISSN： 1750-2799 Impact factor: 17.021