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Literature DB >> 33984279

Therapeutic targeting of RNA-binding protein by RNA-PROTAC.

Xinyi Li¹, Wenchen Pu², Song Chen³, Yong Peng⁴.

Abstract

Entities: Chemical

Mesh：

Substances：

Year: 2021 PMID： 33984279 PMCID： PMC8178457 DOI： 10.1016/j.ymthe.2021.04.032

Source DB: PubMed Journal: Mol Ther ISSN： 1525-0016 Impact factor: 12.910

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14 in total

Review 1. A census of human RNA-binding proteins.

Authors: Stefanie Gerstberger; Markus Hafner; Thomas Tuschl
Journal: Nat Rev Genet Date: 2014-11-04 Impact factor: 53.242

2. Targeted protein degradation: expanding the toolbox.

Authors: Matthieu Schapira; Matthew F Calabrese; Alex N Bullock; Craig M Crews
Journal: Nat Rev Drug Discov Date: 2019-10-30 Impact factor: 84.694

Review 3. Induced protein degradation: an emerging drug discovery paradigm.

Authors: Ashton C Lai; Craig M Crews
Journal: Nat Rev Drug Discov Date: 2016-11-25 Impact factor: 84.694

4. Functional characterization of a PROTAC directed against BRAF mutant V600E.

Authors: Ganna Posternak; Xiaojing Tang; Pierre Maisonneuve; Ting Jin; Hugo Lavoie; Salima Daou; Stephen Orlicky; Theo Goullet de Rugy; Lauren Caldwell; Kin Chan; Ahmed Aman; Michael Prakesch; Gennady Poda; Pavel Mader; Cassandra Wong; Stefan Maier; Julia Kitaygorodsky; Brett Larsen; Karen Colwill; Zhe Yin; Derek F Ceccarelli; Robert A Batey; Mikko Taipale; Igor Kurinov; David Uehling; Jeff Wrana; Daniel Durocher; Anne-Claude Gingras; Rima Al-Awar; Marc Therrien; Frank Sicheri
Journal: Nat Chem Biol Date: 2020-08-10 Impact factor: 15.040

Review 5. Targeting transcription factors in cancer - from undruggable to reality.

Authors: John H Bushweller
Journal: Nat Rev Cancer Date: 2019-09-11 Impact factor: 60.716

Review 6. Deubiquitylating enzymes and drug discovery: emerging opportunities.

Authors: Jeanine A Harrigan; Xavier Jacq; Niall M Martin; Stephen P Jackson
Journal: Nat Rev Drug Discov Date: 2017-09-29 Impact factor: 84.694

7. Lin28 promotes transformation and is associated with advanced human malignancies.

Authors: Srinivas R Viswanathan; John T Powers; William Einhorn; Yujin Hoshida; Tony L Ng; Sara Toffanin; Maureen O'Sullivan; Jun Lu; Letha A Phillips; Victoria L Lockhart; Samar P Shah; Pradeep S Tanwar; Craig H Mermel; Rameen Beroukhim; Mohammad Azam; Jose Teixeira; Matthew Meyerson; Timothy P Hughes; Josep M Llovet; Jerald Radich; Charles G Mullighan; Todd R Golub; Poul H Sorensen; George Q Daley
Journal: Nat Genet Date: 2009-05-31 Impact factor: 38.330

Therapeutic targeting of RNA-binding protein by RNA-PROTAC.

Review 1. A census of human RNA-binding proteins.

2. Targeted protein degradation: expanding the toolbox.

Review 3. Induced protein degradation: an emerging drug discovery paradigm.

4. Functional characterization of a PROTAC directed against BRAF mutant V600E.

Review 5. Targeting transcription factors in cancer - from undruggable to reality.

Review 6. Deubiquitylating enzymes and drug discovery: emerging opportunities.

7. Lin28 promotes transformation and is associated with advanced human malignancies.

Review 8. The peptide PROTAC modality: a novel strategy for targeted protein ubiquitination.

Review 9. Advances in oligonucleotide drug delivery.

10. RNA-PROTACs: Degraders of RNA-Binding Proteins.

Review 1. PROTACs: great opportunities for academia and industry (an update from 2020 to 2021).

2. RNA-binding proteins modulate drug sensitivity of cancer cells.