BACKGROUND: Liver resection is the most effective available therapy for patients with hepatocellular carcinoma (HCC). The accurate selection of patients for surgery requires determination of technical resectability and the risk of recurrence, as well as assessment of liver function and functional reserve to avoid postoperative liver failure. Previous studies have underlined the effectiveness and reliability of the LiMAx® test to evaluate liver function preoperatively. Nevertheless, data concerning HCC evaluation are lacking. METHODS: From 2014 to 2019, 92 patients with HCC underwent additional assessment of liver function using the LiMAx test prior to decision for or against liver resection. Preoperative LiMAx results were compared between cirrhotic and noncirrhotic liver. The clinical decision for surgery was evaluated applying the various liver function parameters available. RESULTS: Forty-six patients underwent liver resection. The LiMAx results were higher in resected patients (388 vs. 322 µg/kg/h; p = 0.004). LiMAx values were an independent risk factor for the presence of liver cirrhosis in multivariate analysis. In 17 patients, surgical treatment was cancelled due to major impairment of liver function. Only 4 out of 46 resected patients presented with post-hepatectomy liver failure (PHLF) grade ≥B. Histologic assessment revealed liver cirrhosis in 10 resected patients without PHLF. CONCLUSION: Preoperative determination of liver function by the LiMAx test enables effective and safe patient selection for HCC resection in both cirrhotic and noncirrhotic liver.
BACKGROUND: Liver resection is the most effective available therapy for patients with hepatocellular carcinoma (HCC). The accurate selection of patients for surgery requires determination of technical resectability and the risk of recurrence, as well as assessment of liver function and functional reserve to avoid postoperative liver failure. Previous studies have underlined the effectiveness and reliability of the LiMAx® test to evaluate liver function preoperatively. Nevertheless, data concerning HCC evaluation are lacking. METHODS: From 2014 to 2019, 92 patients with HCC underwent additional assessment of liver function using the LiMAx test prior to decision for or against liver resection. Preoperative LiMAx results were compared between cirrhotic and noncirrhotic liver. The clinical decision for surgery was evaluated applying the various liver function parameters available. RESULTS: Forty-six patients underwent liver resection. The LiMAx results were higher in resected patients (388 vs. 322 µg/kg/h; p = 0.004). LiMAx values were an independent risk factor for the presence of liver cirrhosis in multivariate analysis. In 17 patients, surgical treatment was cancelled due to major impairment of liver function. Only 4 out of 46 resected patients presented with post-hepatectomy liver failure (PHLF) grade ≥B. Histologic assessment revealed liver cirrhosis in 10 resected patients without PHLF. CONCLUSION: Preoperative determination of liver function by the LiMAx test enables effective and safe patient selection for HCC resection in both cirrhotic and noncirrhotic liver.
Authors: Martin Stockmann; Johan F Lock; Björn Riecke; Karsten Heyne; Peter Martus; Michael Fricke; Sina Lehmann; Stefan M Niehues; Michael Schwabe; Arne-Jörn Lemke; Peter Neuhaus Journal: Ann Surg Date: 2009-07 Impact factor: 12.969
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Authors: Elisabeth Blüthner; Maximilian Jara; Ritesh Shrestha; Wladimir Faber; Johann Pratschke; Martin Stockmann; Maciej Malinowski Journal: HPB (Oxford) Date: 2019-02-04 Impact factor: 3.647
Authors: Martin Stockmann; Johan F Lock; Maciej Malinowski; Stefan M Niehues; Daniel Seehofer; Peter Neuhaus Journal: HPB (Oxford) Date: 2010-03 Impact factor: 3.647
Authors: Maciej Malinowski; Maximilian Jara; Katja Lüttgert; James Orr; Johan Friso Lock; Eckart Schott; Martin Stockmann Journal: Dig Dis Sci Date: 2014-07-04 Impact factor: 3.199
Authors: Catherine Leyh; Niklas Heucke; Clemens Schotten; Matthias Büchter; Lars P Bechmann; Marc Wichert; Alexander Dechêne; Ken Herrmann; Dominik Heider; Svenja Sydor; Peter Lemmer; Johannes M Ludwig; Josef Pospiech; Jens Theysohn; Robert Damm; Christine March; Maciej Powerski; Maciej Pech; Mustafa Özcürümez; Jochen Weigt; Verena Keitel; Christian M Lange; Hartmut Schmidt; Ali Canbay; Jan Best; Guido Gerken; Paul P Manka Journal: Cancers (Basel) Date: 2022-09-21 Impact factor: 6.575