Maximilian Jara1, Jan Bednarsch1, Erika Valle1, Johan Friso Lock1, Maciej Malinowski1, Antje Schulz1, Daniel Seehofer1, Tobias Jung2, Martin Stockmann3. 1. Department of General, Visceral and Transplantation Surgery, Charité - Universitätsmedizin Berlin -Campus Virchow-Klinikum, Berlin, Germany. 2. Center for Musculoskeletal Surgery, Charité - Universitätsmedizin Berlin - Campus Virchow-Klinikum, Berlin, Germany. 3. Department of General, Visceral and Transplantation Surgery, Charité - Universitätsmedizin Berlin -Campus Virchow-Klinikum, Berlin, Germany. Electronic address: martin.stockmann@charite.de.
Abstract
BACKGROUND: (13)C-liver function breath tests can facilitate the assessment of hepatic function in-vivo and may help surgeons to identify candidates for safe liver surgery. However, their acceptance into clinical practice is dependent on evaluation of technical efficacy and repeatability. The aims of this study were to evaluate the within-subject repeatability of the LiMAx (maximum liver function capacity) test in healthy individuals and in surgical patients to determine liver function in the perioperative workup. MATERIAL AND METHODS: The LiMAx test, which is based on intravenous injection of (13)C-methacetin at a dosage of 2 mg/kg body weight was performed in eighty-six healthy subjects to determine a reference range. Twenty-four subjects underwent repeat LiMAx testing the following day to assess within-subject repeatability. Twenty-one patients undergoing elective extra-abdominal surgery under general anesthesia (GA group) received pre- and post-operative examinations. RESULTS: The normal range of LiMAx was found to be 430 ± 86 μg/kg/h and revealed a one-sided cut-off value of 315 μg/kg/h. The intraclass correlation coefficient of the repeat LiMAx tests was 0.85 (95% confidence interval 0.69-0.93) in the control group and 0.81 (95% confidence interval 0.60-0.92) in the group of patients with GA. CONCLUSIONS: The LiMAx test shows excellent reproducibility in subjects with normal liver function. GA has no effect on test results.
BACKGROUND: (13)C-liver function breath tests can facilitate the assessment of hepatic function in-vivo and may help surgeons to identify candidates for safe liver surgery. However, their acceptance into clinical practice is dependent on evaluation of technical efficacy and repeatability. The aims of this study were to evaluate the within-subject repeatability of the LiMAx (maximum liver function capacity) test in healthy individuals and in surgical patients to determine liver function in the perioperative workup. MATERIAL AND METHODS: The LiMAx test, which is based on intravenous injection of (13)C-methacetin at a dosage of 2 mg/kg body weight was performed in eighty-six healthy subjects to determine a reference range. Twenty-four subjects underwent repeat LiMAx testing the following day to assess within-subject repeatability. Twenty-one patients undergoing elective extra-abdominal surgery under general anesthesia (GA group) received pre- and post-operative examinations. RESULTS: The normal range of LiMAx was found to be 430 ± 86 μg/kg/h and revealed a one-sided cut-off value of 315 μg/kg/h. The intraclass correlation coefficient of the repeat LiMAx tests was 0.85 (95% confidence interval 0.69-0.93) in the control group and 0.81 (95% confidence interval 0.60-0.92) in the group of patients with GA. CONCLUSIONS: The LiMAx test shows excellent reproducibility in subjects with normal liver function. GA has no effect on test results.
Authors: Maximilian Jara; Tomasz Dziodzio; Maciej Malinowski; Katja Lüttgert; Radoslav Nikolov; Paul Viktor Ritschl; Robert Öllinger; Johann Pratschke; Martin Stockmann Journal: Dig Dis Sci Date: 2018-11-07 Impact factor: 3.199
Authors: Jan Bednarsch; Elisabeth Blüthner; Maciej Malinowski; Daniel Seehofer; Johann Pratschke; Martin Stockmann Journal: World J Surg Date: 2016-09 Impact factor: 3.352
Authors: Felix Krenzien; Moritz Schmelzle; Benjamin Struecker; Nathanael Raschzok; Christian Benzing; Maximilian Jara; Marcus Bahra; Robert Öllinger; Igor M Sauer; Andreas Pascher; Johann Pratschke; Andreas Andreou Journal: J Gastrointest Surg Date: 2018-01-23 Impact factor: 3.452
Authors: Maximilian Jara; Tim Reese; Maciej Malinowski; Erika Valle; Daniel Seehofer; Gero Puhl; Peter Neuhaus; Johann Pratschke; Martin Stockmann Journal: HPB (Oxford) Date: 2015-07 Impact factor: 3.647
Authors: Friedrich Anger; Ingo Klein; Stefan Löb; Armin Wiegering; Gurinder Singh; Dominique Sperl; Oliver Götze; Andreas Geier; Johan Friso Lock Journal: Visc Med Date: 2020-06-12
Authors: Florian Wolfgang Rudolf Vondran; Carsten Schumacher; Kai Johanning; Björn Hartleben; Wolfgang Knitsch; Olaf Wiesner; Elmar Jaeckel; Michael Peter Manns; Juergen Klempnauer; Hueseyin Bektas; Frank Lehner Journal: Case Rep Transplant Date: 2016-05-04
Authors: M Stockmann; F W R Vondran; R Fahrner; H M Tautenhahn; J Mittler; H Bektas; M Malinowski; M Jara; I Klein; J F Lock Journal: BJS Open Date: 2018-06-14
Authors: Eva-Maria Wittauer; Felix Oldhafer; Eva Augstein; Oliver Beetz; Moritz Kleine; Carsten Schumacher; Lion Sieg; Hendrik Eismann; Kai Johanning; André Bleich; Florian Wolfgang Rudolf Vondran Journal: PLoS One Date: 2019-05-31 Impact factor: 3.240
Authors: Bruno Christ; Uta Dahmen; Karl-Heinz Herrmann; Matthias König; Jürgen R Reichenbach; Tim Ricken; Jana Schleicher; Lars Ole Schwen; Sebastian Vlaic; Navina Waschinsky Journal: Front Physiol Date: 2017-11-14 Impact factor: 4.566