Literature DB >> 33966451

Gut Microbiome-Derived Metabolite Trimethylamine N-Oxide Induces Aortic Stiffening and Increases Systolic Blood Pressure With Aging in Mice and Humans.

Vienna E Brunt1, Abigail G Casso1, Rachel A Gioscia-Ryan1, Zachary J Sapinsley1, Brian P Ziemba1, Zachary S Clayton1, Amy E Bazzoni1, Nicholas S VanDongen1, James J Richey1, David A Hutton1, Melanie C Zigler1, Andrew P Neilson2,3, Kevin P Davy4, Douglas R Seals1.   

Abstract

[Figure: see text].

Entities:  

Keywords:  advanced glycation end products; arterial stiffness; gut microbiota; pulse wave velocity

Mesh：

Substances：

Year:  2021        PMID： 33966451      PMCID： PMC8266738          DOI： 10.1161/HYPERTENSIONAHA.120.16895

Source DB:  PubMed          Journal:  Hypertension        ISSN： 0194-911X            Impact factor:   9.897


  60 in total

Review 1.  Mechanisms, pathophysiology, and therapy of arterial stiffness.

Authors:  Susan J Zieman; Vojtech Melenovsky; David A Kass
Journal:  Arterioscler Thromb Vasc Biol       Date:  2005-02-24       Impact factor: 8.311

2.  Differential effect of short-term popular diets on TMAO and other cardio-metabolic risk markers.

Authors:  J E Park; M Miller; J Rhyne; Z Wang; S L Hazen
Journal:  Nutr Metab Cardiovasc Dis       Date:  2019-02-22       Impact factor: 4.222

3.  Aortic stiffness is an independent predictor of primary coronary events in hypertensive patients: a longitudinal study.

Authors:  Pierre Boutouyrie; Anne Isabelle Tropeano; Roland Asmar; Isabelle Gautier; Athanase Benetos; Patrick Lacolley; Stéphane Laurent
Journal:  Hypertension       Date:  2002-01       Impact factor: 10.190

4.  Prognostic value of elevated levels of intestinal microbe-generated metabolite trimethylamine-N-oxide in patients with heart failure: refining the gut hypothesis.

Authors:  W H Wilson Tang; Zeneng Wang; Yiying Fan; Bruce Levison; Jennie E Hazen; Lillian M Donahue; Yuping Wu; Stanley L Hazen
Journal:  J Am Coll Cardiol       Date:  2014-10-27       Impact factor: 24.094

Review 5.  Killing Me Unsoftly: Causes and Mechanisms of Arterial Stiffness.

Authors:  Alicia N Lyle; Uwe Raaz
Journal:  Arterioscler Thromb Vasc Biol       Date:  2017-02       Impact factor: 8.311

6.  Soluble Dietary Fiber Reduces Trimethylamine Metabolism via Gut Microbiota and Co-Regulates Host AMPK Pathways.

Authors:  Qian Li; Tao Wu; Rui Liu; Min Zhang; Ruijun Wang
Journal:  Mol Nutr Food Res       Date:  2017-11-16       Impact factor: 5.914

7.  Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products.

Authors:  Bradley S Fleenor; Amy L Sindler; Jason S Eng; Devatha P Nair; R Blair Dodson; Douglas R Seals
Journal:  Exp Gerontol       Date:  2012-05-12       Impact factor: 4.032

8.  Tissue Transglutaminase Modulates Vascular Stiffness and Function Through Crosslinking-Dependent and Crosslinking-Independent Functions.

Authors:  Jochen Steppan; Yehudit Bergman; Kayla Viegas; Dinani Armstrong; Siqi Tan; Huilei Wang; Sean Melucci; Daijiro Hori; Sung Yong Park; Sebastian F Barreto; Abraham Isak; Sandeep Jandu; Nicholas Flavahan; Mark Butlin; Steven S An; Alberto Avolio; Dan E Berkowitz; Marc K Halushka; Lakshmi Santhanam
Journal:  J Am Heart Assoc       Date:  2017-02-03       Impact factor: 5.501

9.  Late-life voluntary wheel running reverses age-related aortic stiffness in mice: a translational model for studying mechanisms of exercise-mediated arterial de-stiffening.

Authors:  Rachel A Gioscia-Ryan; Zachary S Clayton; Bradley S Fleenor; Jason S Eng; Lawrence C Johnson; Matthew J Rossman; Melanie C Zigler; Trent D Evans; Douglas R Seals
Journal:  Geroscience       Date:  2020-06-11       Impact factor: 7.713

10.  Mitochondria-targeted antioxidant therapy with MitoQ ameliorates aortic stiffening in old mice.

Authors:  Rachel A Gioscia-Ryan; Micah L Battson; Lauren M Cuevas; Jason S Eng; Michael P Murphy; Douglas R Seals
Journal:  J Appl Physiol (1985)       Date:  2017-10-26
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  17 in total

1.  Suppression of trimethylamine N-oxide with DMB mitigates vascular dysfunction, exercise intolerance, and frailty associated with a Western-style diet in mice.

Authors:  Vienna E Brunt; Nathan T Greenberg; Zachary J Sapinsley; Abigail G Casso; James J Richey; Nicholas S VanDongen; Rachel A Gioscia-Ryan; Brian P Ziemba; Andrew P Neilson; Kevin P Davy; Douglas R Seals
Journal:  J Appl Physiol (1985)       Date:  2022-08-11

Review 2.  Gut microbiota, dysbiosis and atrial fibrillation. Arrhythmogenic mechanisms and potential clinical implications.

Authors:  Monika Gawałko; Thomas A Agbaedeng; Arnela Saljic; Dominik N Müller; Nicola Wilck; Renate Schnabel; John Penders; Michiel Rienstra; Isabelle van Gelder; Thomas Jespersen; Ulrich Schotten; Harry J G M Crijns; Jonathan M Kalman; Prashanthan Sanders; Stanley Nattel; Dobromir Dobrev; Dominik Linz
Journal:  Cardiovasc Res       Date:  2022-08-24       Impact factor: 13.081

3.  Identifying a metabolomics profile associated with masked hypertension in two independent cohorts: Data from the African-PREDICT and SABPA studies.

Authors:  Michél Strauss-Kruger; Ruan Kruger; Esmé Jansen Van Vuren; Adriaan Jacobs; Roan Louw; Carina Mels
Journal:  Hypertens Res       Date:  2022-09-02       Impact factor: 5.528

Review 4.  The Gut Microbiota and Vascular Aging: A State-of-the-Art and Systematic Review of the Literature.

Authors:  Davide Agnoletti; Federica Piani; Arrigo F G Cicero; Claudio Borghi
Journal:  J Clin Med       Date:  2022-06-20       Impact factor: 4.964

Review 5.  Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs.

Authors:  Aleksandra Twarda-Clapa; Aleksandra Olczak; Aneta M Białkowska; Maria Koziołkiewicz
Journal:  Cells       Date:  2022-04-12       Impact factor: 7.666

6.  The Gut-Arterial Stiffness Axis: Is TMAO a Novel Target to Prevent Age-Related Aortic Stiffening?

Authors:  Gary L Pierce; Stephen J Roy; Colin J Gimblet
Journal:  Hypertension       Date:  2021-07-07       Impact factor: 9.897

Review 7.  Significance of the Gut Microbiome for Viral Diarrheal and Extra-Intestinal Diseases.

Authors:  Ulrich Desselberger
Journal:  Viruses       Date:  2021-08-12       Impact factor: 5.048

8.  Common Metabolites in Two Different Hypertensive Mouse Models: A Serum and Urine Metabolome Study.

Authors:  Gaurav Baranwal; Rachel Pilla; Bethany L Goodlett; Aja K Coleman; Cristina M Arenaz; Arul Jayaraman; Joseph M Rutkowski; Robert C Alaniz; Brett M Mitchell
Journal:  Biomolecules       Date:  2021-09-21

9.  Berberine Improves Vascular Dysfunction by Inhibiting Trimethylamine-N-oxide via Regulating the Gut Microbiota in Angiotensin II-Induced Hypertensive Mice.

Authors:  Zhichao Wang; Fang Wu; Qianbing Zhou; Yumin Qiu; Jianning Zhang; Qiang Tu; Zhe Zhou; Yijia Shao; Shiyue Xu; Yan Wang; Jun Tao
Journal:  Front Microbiol       Date:  2022-03-08       Impact factor: 5.640

Review 10.  Maternal Fructose Diet-Induced Developmental Programming.

Authors:  Michael D Thompson; Brian J DeBosch
Journal:  Nutrients       Date:  2021-09-20       Impact factor: 5.717
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