Literature DB >> 33862230

Critical carE Database for Advanced Research (CEDAR): An automated method to support intensive care units with electronic health record data.

Edward J Schenck1, Katherine L Hoffman2, Marika Cusick3, Joseph Kabariti3, Evan T Sholle3, Thomas R Campion4.   

Abstract

Patients treated in an intensive care unit (ICU) are critically ill and require life-sustaining organ failure support. Existing critical care data resources are limited to a select number of institutions, contain only ICU data, and do not enable the study of local changes in care patterns. To address these limitations, we developed the Critical carE Database for Advanced Research (CEDAR), a method for automating extraction and transformation of data from an electronic health record (EHR) system. Compared to an existing gold standard of manually collected data at our institution, CEDAR was statistically similar in most measures, including patient demographics and sepsis-related organ failure assessment (SOFA) scores. Additionally, CEDAR automated data extraction obviated the need for manual collection of 550 variables. Critically, during the spring 2020 COVID-19 surge in New York City, a modified version of CEDAR supported pandemic response efforts, including clinical operations and research. Other academic medical centers may find value in using the CEDAR method to automate data extraction from EHR systems to support ICU activities.
Copyright © 2021 Elsevier Inc. All rights reserved.

Entities:  

Keywords:  COVID-19; Intensive care unit; Secondary use of electronic health record data

Mesh:

Year:  2021        PMID: 33862230      PMCID: PMC8187305          DOI: 10.1016/j.jbi.2021.103789

Source DB:  PubMed          Journal:  J Biomed Inform        ISSN: 1532-0464            Impact factor:   8.000


  26 in total

1.  Research electronic data capture (REDCap)--a metadata-driven methodology and workflow process for providing translational research informatics support.

Authors:  Paul A Harris; Robert Taylor; Robert Thielke; Jonathon Payne; Nathaniel Gonzalez; Jose G Conde
Journal:  J Biomed Inform       Date:  2008-09-30       Impact factor: 6.317

2.  "Big data" in the intensive care unit. Closing the data loop.

Authors:  Leo Anthony Celi; Roger G Mark; David J Stone; Robert A Montgomery
Journal:  Am J Respir Crit Care Med       Date:  2013-06-01       Impact factor: 21.405

3.  Secondary Use of Patients' Electronic Records (SUPER): An Approach for Meeting Specific Data Needs of Clinical and Translational Researchers.

Authors:  Evan T Sholle; Joseph Kabariti; Stephen B Johnson; John P Leonard; Jyotishman Pathak; Vinay I Varughese; Curtis L Cole; Thomas R Campion
Journal:  AMIA Annu Symp Proc       Date:  2018-04-16

4.  Subphenotypes in acute respiratory distress syndrome: latent class analysis of data from two randomised controlled trials.

Authors:  Carolyn S Calfee; Kevin Delucchi; Polly E Parsons; B Taylor Thompson; Lorraine B Ware; Michael A Matthay
Journal:  Lancet Respir Med       Date:  2014-05-19       Impact factor: 30.700

5.  Derivation, Validation, and Potential Treatment Implications of Novel Clinical Phenotypes for Sepsis.

Authors:  Christopher W Seymour; Jason N Kennedy; Shu Wang; Chung-Chou H Chang; Corrine F Elliott; Zhongying Xu; Scott Berry; Gilles Clermont; Gregory Cooper; Hernando Gomez; David T Huang; John A Kellum; Qi Mi; Steven M Opal; Victor Talisa; Tom van der Poll; Shyam Visweswaran; Yoram Vodovotz; Jeremy C Weiss; Donald M Yealy; Sachin Yende; Derek C Angus
Journal:  JAMA       Date:  2019-05-28       Impact factor: 56.272

6.  APACHE II: a severity of disease classification system.

Authors:  W A Knaus; E A Draper; D P Wagner; J E Zimmerman
Journal:  Crit Care Med       Date:  1985-10       Impact factor: 7.598

7.  Immunology. Getting sepsis therapy right.

Authors:  Richard S Hotchkiss; Edward R Sherwood
Journal:  Science       Date:  2015-03-13       Impact factor: 47.728

8.  Hospital-level variation in ICU admission and critical care procedures for patients hospitalized for pulmonary embolism.

Authors:  Andrew J Admon; Christopher W Seymour; Hayley B Gershengorn; Hannah Wunsch; Colin R Cooke
Journal:  Chest       Date:  2014-12       Impact factor: 9.410

9.  Generalizable Middleware to Support Use of REDCap Dynamic Data Pull for Integrating Clinical and Research Data.

Authors:  Thomas R Campion; Evan T Sholle; Marcos A Davila
Journal:  AMIA Jt Summits Transl Sci Proc       Date:  2017-07-26

10.  MIMIC-III, a freely accessible critical care database.

Authors:  Alistair E W Johnson; Tom J Pollard; Lu Shen; Li-Wei H Lehman; Mengling Feng; Mohammad Ghassemi; Benjamin Moody; Peter Szolovits; Leo Anthony Celi; Roger G Mark
Journal:  Sci Data       Date:  2016-05-24       Impact factor: 6.444

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  10 in total

1.  Comparison of a Target Trial Emulation Framework vs Cox Regression to Estimate the Association of Corticosteroids With COVID-19 Mortality.

Authors:  Katherine L Hoffman; Edward J Schenck; Michael J Satlin; William Whalen; Di Pan; Nicholas Williams; Iván Díaz
Journal:  JAMA Netw Open       Date:  2022-10-03

2.  Corticosteroids in COVID-19: Optimizing Observational Research through Target Trial Emulations.

Authors:  Katherine L Hoffman; Edward J Schenck; Michael J Satlin; William Whalen; Di Pan; Nicholas Williams; Iván Díaz
Journal:  medRxiv       Date:  2022-06-07

3.  Understanding enterprise data warehouses to support clinical and translational research: enterprise information technology relationships, data governance, workforce, and cloud computing.

Authors:  Boyd M Knosp; Catherine K Craven; David A Dorr; Elmer V Bernstam; Thomas R Campion
Journal:  J Am Med Inform Assoc       Date:  2022-03-15       Impact factor: 7.942

4.  Critical Care Database Comprising Patients With Infection.

Authors:  Ping Xu; Lin Chen; Yuanfang Zhu; Shuai Yu; Rangui Chen; Wenbin Huang; Fuli Wu; Zhongheng Zhang
Journal:  Front Public Health       Date:  2022-03-17

5.  Identifying organ dysfunction trajectory-based subphenotypes in critically ill patients with COVID-19.

Authors:  Chang Su; Zhenxing Xu; Katherine Hoffman; Parag Goyal; Monika M Safford; Jerry Lee; Sergio Alvarez-Mulett; Luis Gomez-Escobar; David R Price; John S Harrington; Lisa K Torres; Fernando J Martinez; Thomas R Campion; Fei Wang; Edward J Schenck
Journal:  Sci Rep       Date:  2021-08-05       Impact factor: 4.996

6.  Evaluation of Albumin Kinetics in Critically Ill Patients With Coronavirus Disease 2019 Compared to Those With Sepsis-Induced Acute Respiratory Distress Syndrome.

Authors:  Chang Su; Katherine L Hoffman; Zhenxing Xu; Elizabeth Sanchez; Ilias I Siempos; John S Harrington; Alexandra C Racanelli; Maria Plataki; Fei Wang; Edward J Schenck
Journal:  Crit Care Explor       Date:  2021-12-02

7.  An architecture for research computing in health to support clinical and translational investigators with electronic patient data.

Authors:  Thomas R Campion; Evan T Sholle; Jyotishman Pathak; Stephen B Johnson; John P Leonard; Curtis L Cole
Journal:  J Am Med Inform Assoc       Date:  2022-03-15       Impact factor: 4.497

8.  Novel informatics approaches to COVID-19 Research: From methods to applications.

Authors:  Hua Xu; David L Buckeridge; Fei Wang; Peter Tarczy-Hornoch
Journal:  J Biomed Inform       Date:  2022-02-16       Impact factor: 8.000

9.  Sepsis subphenotyping based on organ dysfunction trajectory.

Authors:  Zhenxing Xu; Chengsheng Mao; Chang Su; Hao Zhang; Ilias Siempos; Lisa K Torres; Di Pan; Yuan Luo; Edward J Schenck; Fei Wang
Journal:  Crit Care       Date:  2022-07-03       Impact factor: 19.334

10.  Integrative metabolomic and proteomic signatures define clinical outcomes in severe COVID-19.

Authors:  Mustafa Buyukozkan; Sergio Alvarez-Mulett; Alexandra C Racanelli; Frank Schmidt; Richa Batra; Katherine L Hoffman; Hina Sarwath; Rudolf Engelke; Luis Gomez-Escobar; Will Simmons; Elisa Benedetti; Kelsey Chetnik; Guoan Zhang; Edward Schenck; Karsten Suhre; Justin J Choi; Zhen Zhao; Sabrina Racine-Brzostek; He S Yang; Mary E Choi; Augustine M K Choi; Soo Jung Cho; Jan Krumsiek
Journal:  iScience       Date:  2022-06-17
  10 in total

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