Adina Zeki Al Hazzouri1, Michelle R Caunca2,3, Neal Jawadekar1, Leslie Grasset4, Tali Elfassy5, Michelle C Odden6, Chenkai Wu7, Martine Elbejjani8, Lenore Launer9, Kristine Yaffe10. 1. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York, USA. 2. Departments of Neurology and Public Health Sciences, Miller School of Medicine, University of Miami, Florida, USA. 3. Evelyn F. McKnight Brain Institute, Miller School of Medicine, University of Miami, Florida, USA. 4. Université de Bordeaux, INSERM, Bordeaux Population Health Research Center, Team VINTAGE UMR1219, France. 5. Division of Epidemiology, Department of Public Health Sciences, University of Miami, Florida, USA. 6. Department of Health Research and Policy, Stanford University, Palo Alto, California, USA. 7. Department of Global Health, Duke Kunshan University, Suzhou,China. 8. Clinical Research Institute, Department of Internal Medicine, American University of Beirut, Lebanon. 9. Laboratory of Epidemiology and Population Science, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA. 10. Departments of Psychiatry, Neurology, and Epidemiology and Biostatistics, University of California San Francisco, USA.
Abstract
BACKGROUND: Little is known about long-term lipid variability in young adulthood in relation to cognitive function and brain integrity in midlife. METHOD: We studied 3 328 adults from the Coronary Artery Risk Development in Young Adults. We defined low- and high-density lipoprotein (LDL and HDL) variability as the intraindividual standard deviation of lipid measurements over 20 years of young adulthood (1985-2005). Cognitive tests were administered in 2010. Brain scans were performed in 2010 on 714 participants. To facilitate comparison, cognitive tests and brain metrics were z-scored. RESULTS: Mean age at baseline was 25.4 years. Higher 20-year LDL variability was associated with worse verbal memory in midlife (β = -0.25, 95% CI: -0.42, -0.08), adjusted for important covariates. Higher 20-year HDL variability was associated with worse processing speed in midlife (β = -0.80, 95% CI: -1.18, -0.41) and brain integrity, for example, smaller total brain volume (β = -0.58, 95% CI: -0.82, -0.34) and worse total brain fractional anisotropy (β = -1.13, 95% CI: -1.87, -0.39). CONCLUSIONS: Higher long-term lipid variability in adulthood was associated with worse cognition and brain integrity in midlife, in a relatively young cohort.
BACKGROUND: Little is known about long-term lipid variability in young adulthood in relation to cognitive function and brain integrity in midlife. METHOD: We studied 3 328 adults from the Coronary Artery Risk Development in Young Adults. We defined low- and high-density lipoprotein (LDL and HDL) variability as the intraindividual standard deviation of lipid measurements over 20 years of young adulthood (1985-2005). Cognitive tests were administered in 2010. Brain scans were performed in 2010 on 714 participants. To facilitate comparison, cognitive tests and brain metrics were z-scored. RESULTS: Mean age at baseline was 25.4 years. Higher 20-year LDL variability was associated with worse verbal memory in midlife (β = -0.25, 95% CI: -0.42, -0.08), adjusted for important covariates. Higher 20-year HDL variability was associated with worse processing speed in midlife (β = -0.80, 95% CI: -1.18, -0.41) and brain integrity, for example, smaller total brain volume (β = -0.58, 95% CI: -0.82, -0.34) and worse total brain fractional anisotropy (β = -1.13, 95% CI: -1.87, -0.39). CONCLUSIONS: Higher long-term lipid variability in adulthood was associated with worse cognition and brain integrity in midlife, in a relatively young cohort.
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