OBJECTIVE: To reexamine the association of lipid levels with Alzheimer disease (AD) using Cox proportional hazards models. DESIGN: Prospective cohort study. SETTING: Northern Manhattan, New York. PARTICIPANTS: One thousand one hundred thirty elderly individuals free of cognitive impairment at baseline. MAIN OUTCOME MEASURE: High-density lipoprotein cholesterol (HDL-C) levels. RESULTS: Higher levels of HDL-C (>55 mg/dL) were associated with a decreased risk of both probable and possible AD and probable AD compared with lower HDL-C levels (hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03 and hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03). In addition, higher levels of total and non-HDL-C were associated with a decreased risk of AD in analyses adjusting for age, sex, education, ethnic group, and APOE e4 genotype. CONCLUSION: High HDL-C levels in elderly individuals may be associated with a decreased risk of AD.
OBJECTIVE: To reexamine the association of lipid levels with Alzheimer disease (AD) using Cox proportional hazards models. DESIGN: Prospective cohort study. SETTING: Northern Manhattan, New York. PARTICIPANTS: One thousand one hundred thirty elderly individuals free of cognitive impairment at baseline. MAIN OUTCOME MEASURE: High-density lipoprotein cholesterol (HDL-C) levels. RESULTS: Higher levels of HDL-C (>55 mg/dL) were associated with a decreased risk of both probable and possible AD and probable AD compared with lower HDL-C levels (hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03 and hazard ratio, 0.4; 95% confidence interval, 0.2-0.9; P = .03). In addition, higher levels of total and non-HDL-C were associated with a decreased risk of AD in analyses adjusting for age, sex, education, ethnic group, and APOE e4 genotype. CONCLUSION: High HDL-C levels in elderly individuals may be associated with a decreased risk of AD.
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Authors: R Cooper; J Cutler; P Desvigne-Nickens; S P Fortmann; L Friedman; R Havlik; G Hogelin; J Marler; P McGovern; G Morosco; L Mosca; T Pearson; J Stamler; D Stryer; T Thom Journal: Circulation Date: 2000-12-19 Impact factor: 29.690
Authors: R Scacchi; L De Bernardini; E Mantuano; T Vilardo; L M Donini; M Ruggeri; A T Gemma; R Pascone; R M Corbo Journal: Dement Geriatr Cogn Disord Date: 1998 Jul-Aug Impact factor: 2.959
Authors: Ihab Hajjar; Jeannie Schumpert; Victor Hirth; Darryl Wieland; G Paul Eleazer Journal: J Gerontol A Biol Sci Med Sci Date: 2002-07 Impact factor: 6.053
Authors: Bruce R Reed; Natalie L Marchant; William J Jagust; Charles C DeCarli; Wendy Mack; Helena C Chui Journal: Neurobiol Aging Date: 2011-11-10 Impact factor: 4.673
Authors: Juho Tynkkynen; Jussi A Hernesniemi; Tiina Laatikainen; Aki S Havulinna; Jouko Sundvall; Jaana Leiviskä; Perttu Salo; Veikko Salomaa Journal: Age (Dordr) Date: 2016-09-23