Laure Carcaillon1, Matthieu Plichart2, Mahmoud Zureik3, Olivier Rouaud4, Bilal Majed5, Karen Ritchie6, Christophe Tzourio7, Jean-François Dartigues8, Jean-Philippe Empana9. 1. Inserm, CESP Centre for Research in Epidemiology and Population Health, UMR-S1018, Hormones and Cardiovascular Disease, University Paris Sud, Villejuif, France. 2. Inserm, UMR-S 970, Paris Descartes University, Sorbonne Paris Cité, Paris Cardiovascular Research Center, Paris, France; Assistance Publique - Hôpitaux de Paris, Hôpital Broca, Paris, France. Electronic address: matthieu.plichart@inserm.fr. 3. Inserm U700, Paris, France. 4. CMMR CHU Dijon, Dijon, France. 5. Inserm, UMR-S 970, Paris Descartes University, Sorbonne Paris Cité, Paris Cardiovascular Research Center, Paris, France; Epidemiology and Clinical Research Unit, Arras General Hospital, Arras, France. 6. Inserm U1061, Neuropsychiatry: Epidemiological and Clinical Research, Hôpital La Colombière, Montpellier, France; Imperial College, Faculty of Medicine, London, United Kingdom; University of Montpellier 1, Faculty of Medicine, Montpellier, France. 7. Inserm U708, Neuroepidemiology, Bordeaux, France; University of Victor Segalen Bordeaux2, Bordeaux, France. 8. University of Victor Segalen Bordeaux2, Bordeaux, France; Inserm U897, Epidemiology and Neuropsychology of Brain Aging, Bordeaux, France. 9. Inserm, UMR-S 970, Paris Descartes University, Sorbonne Paris Cité, Paris Cardiovascular Research Center, Paris, France.
Abstract
BACKGROUND: The contribution of carotid atherosclerosis to incident dementia remains unclear. We examined the association between carotid plaques (CP) and common carotid intima media thickness (CCA-IMT) with incident dementia and its subtypes, and their added value for dementia risk prediction. METHODS: At baseline, 6025 dementia-free subjects aged 65-86 years underwent bilateral carotid ultrasonography measures of CP and plaque-free CCA-IMT. Subjects were followed-up over 7 years for the detection of dementia. RESULTS: After a mean 5.4 years of follow-up, 421 subjects developed dementia including 272 Alzheimer's disease and 83 vascular/mixed dementia (VaD). Only CP were independently related to VaD (HR(≥2 sites with plaques) = 1.92; 95% confidence interval or CI = 1.13-3.22) and improved VaD risk prediction (continuous Net Reclassification Index = 30.1%; 95% CI = 8.4-51.7) beyond known dementia risk factors. Accounting for stroke or competing risk by death marginally modified the results. CONCLUSION: In older adults, CP are independent predictors of incident VaD and may improve VaD risk prediction.
BACKGROUND: The contribution of carotid atherosclerosis to incident dementia remains unclear. We examined the association between carotid plaques (CP) and common carotid intima media thickness (CCA-IMT) with incident dementia and its subtypes, and their added value for dementia risk prediction. METHODS: At baseline, 6025 dementia-free subjects aged 65-86 years underwent bilateral carotid ultrasonography measures of CP and plaque-free CCA-IMT. Subjects were followed-up over 7 years for the detection of dementia. RESULTS: After a mean 5.4 years of follow-up, 421 subjects developed dementia including 272 Alzheimer's disease and 83 vascular/mixed dementia (VaD). Only CP were independently related to VaD (HR(≥2 sites with plaques) = 1.92; 95% confidence interval or CI = 1.13-3.22) and improved VaD risk prediction (continuous Net Reclassification Index = 30.1%; 95% CI = 8.4-51.7) beyond known dementia risk factors. Accounting for stroke or competing risk by death marginally modified the results. CONCLUSION: In older adults, CP are independent predictors of incident VaD and may improve VaD risk prediction.
Authors: Wendy Wang; Faye L Norby; Kristen M George; Alvaro Alonso; Thomas H Mosley; Rebecca F Gottesman; Michelle L Meyer; Pamela L Lutsey Journal: J Am Heart Assoc Date: 2021-04-17 Impact factor: 5.501
Authors: Dorien M A Hermkens; Olga C G Stam; Nienke M de Wit; Ruud D Fontijn; Aldo Jongejan; Perry D Moerland; Claire Mackaaij; Ingeborg S E Waas; Mat J A P Daemen; Helga E de Vries Journal: Acta Neuropathol Commun Date: 2019-10-14 Impact factor: 7.801
Authors: Anna-Märta Gustavsson; Danielle van Westen; Erik Stomrud; Gunnar Engström; Katarina Nägga; Oskar Hansson Journal: Ann Neurol Date: 2019-11-27 Impact factor: 10.422
Authors: Rayan Anbar; Salahaden R Sultan; Lamia Al Saikhan; Mohammed Alkharaiji; Nishi Chaturvedi; Rebecca Hardy; Marcus Richards; Alun Hughes Journal: BMJ Open Date: 2022-04-19 Impact factor: 3.006