Literature DB >> 33771847

The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies.

Jinyoung Byun1,2, Younghun Han1,2, Quinn T Ostrom2, Jacob Edelson3, Kyle M Walsh4, Rowland W Pettit1, Melissa L Bondy5, Rayjean J Hung6,7, James D McKay8, Christopher I Amos.   

Abstract

BACKGROUND: Prior genome-wide association studies have identified numerous lung cancer risk loci and reveal substantial etiologic heterogeneity across histologic subtypes. Analyzing the shared genetic architecture underlying variation in complex traits can elucidate common genetic etiologies across phenotypes. Exploring pairwise genetic correlations between lung cancer and other polygenic traits can reveal the common genetic etiology of correlated phenotypes.
METHODS: Using cross-trait linkage disequilibrium score regression, we estimated the pairwise genetic correlation and heritability between lung cancer and multiple traits using publicly available summary statistics. Identified genetic relationships were also examined after excluding genomic regions known to be associated with smoking behaviors, a major risk factor for lung cancer.
RESULTS: We observed several traits showing moderate single nucleotide polymorphism-based heritability and significant genetic correlations with lung cancer. We observed highly significant correlations between the genetic architectures of lung cancer and emphysema/chronic bronchitis across all histologic subtypes, as well as among lung cancer occurring among smokers. Our analyses revealed highly significant positive correlations between lung cancer and paternal history of lung cancer. We also observed a strong negative correlation with parental longevity. We observed consistent directions in genetic patterns after excluding genomic regions associated with smoking behaviors.
CONCLUSIONS: This study identifies numerous phenotypic traits that share genomic architecture with lung carcinogenesis and are not fully accounted for by known smoking-associated genomic loci. IMPACT: These findings provide new insights into the etiology of lung cancer by identifying traits that are genetically correlated with increased risk of lung cancer. ©2021 American Association for Cancer Research.

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Year:  2021        PMID： 33771847      PMCID： PMC9108090          DOI： 10.1158/1055-9965.EPI-20-1635

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.090


  54 in total

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Authors:  H Gilbert Welch; William C Black
Journal:  J Natl Cancer Inst       Date:  2010-04-22       Impact factor: 13.506

2.  Replication of lung cancer susceptibility loci at chromosomes 15q25, 5p15, and 6p21: a pooled analysis from the International Lung Cancer Consortium.

Authors:  Therese Truong; Rayjean J Hung; Christopher I Amos; Xifeng Wu; Heike Bickeböller; Albert Rosenberger; Wiebke Sauter; Thomas Illig; H-Erich Wichmann; Angela Risch; Hendrik Dienemann; Rudolph Kaaks; Ping Yang; Ruoxiang Jiang; John K Wiencke; Margaret Wrensch; Helen Hansen; Karl T Kelsey; Keitaro Matsuo; Kazuo Tajima; Ann G Schwartz; Angie Wenzlaff; Adeline Seow; Chen Ying; Andrea Staratschek-Jox; Peter Nürnberg; Erich Stoelben; Jürgen Wolf; Philip Lazarus; Joshua E Muscat; Carla J Gallagher; Shanbeh Zienolddiny; Aage Haugen; Henricus F M van der Heijden; Lambertus A Kiemeney; Dolores Isla; Jose Ignacio Mayordomo; Thorunn Rafnar; Kari Stefansson; Zuo-Feng Zhang; Shen-Chih Chang; Jin Hee Kim; Yun-Chul Hong; Eric J Duell; Angeline S Andrew; Flavio Lejbkowicz; Gad Rennert; Heiko Müller; Hermann Brenner; Loïc Le Marchand; Simone Benhamou; Christine Bouchardy; M Dawn Teare; Xiaoyan Xue; John McLaughlin; Geoffrey Liu; James D McKay; Paul Brennan; Margaret R Spitz
Journal:  J Natl Cancer Inst       Date:  2010-06-14       Impact factor: 13.506

3.  Allergies and Asthma in Relation to Cancer Risk.

Authors:  Elizabeth D Kantor; Meier Hsu; Mengmeng Du; Lisa B Signorello
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2019-06-05       Impact factor: 4.254

4.  A new approach to disentangle genetic and epigenetic components on disease comorbidities: studying correlation between genotypic and phenotypic disease networks.

Authors:  G Tradigo; R Vacca; T Manini; V Bird; T Gerke; P Veltri; M Prosperi
Journal:  Procedia Comput Sci       Date:  2017-07-12

5.  Familial cancer aggregation and the risk of lung cancer.

Authors:  Victor Wünsch-Filho; Paolo Boffetta; Didier Colin; José Eduardo Moncau
Journal:  Sao Paulo Med J       Date:  2002-03-07       Impact factor: 1.044

6.  A variant associated with nicotine dependence, lung cancer and peripheral arterial disease.

Authors:  Thorgeir E Thorgeirsson; Frank Geller; Patrick Sulem; Thorunn Rafnar; Anna Wiste; Kristinn P Magnusson; Andrei Manolescu; Gudmar Thorleifsson; Hreinn Stefansson; Andres Ingason; Simon N Stacey; Jon T Bergthorsson; Steinunn Thorlacius; Julius Gudmundsson; Thorlakur Jonsson; Margret Jakobsdottir; Jona Saemundsdottir; Olof Olafsdottir; Larus J Gudmundsson; Gyda Bjornsdottir; Kristleifur Kristjansson; Halla Skuladottir; Helgi J Isaksson; Tomas Gudbjartsson; Gregory T Jones; Thomas Mueller; Anders Gottsäter; Andrea Flex; Katja K H Aben; Femmie de Vegt; Peter F A Mulders; Dolores Isla; Maria J Vidal; Laura Asin; Berta Saez; Laura Murillo; Thorsteinn Blondal; Halldor Kolbeinsson; Jon G Stefansson; Ingunn Hansdottir; Valgerdur Runarsdottir; Roberto Pola; Bengt Lindblad; Andre M van Rij; Benjamin Dieplinger; Meinhard Haltmayer; Jose I Mayordomo; Lambertus A Kiemeney; Stefan E Matthiasson; Hogni Oskarsson; Thorarinn Tyrfingsson; Daniel F Gudbjartsson; Jeffrey R Gulcher; Steinn Jonsson; Unnur Thorsteinsdottir; Augustine Kong; Kari Stefansson
Journal:  Nature       Date:  2008-04-03       Impact factor: 49.962

Review 7.  A Decade of GWAS Results in Lung Cancer.

Authors:  Yohan Bossé; Christopher I Amos
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2017-06-14       Impact factor: 4.254

8.  Quantifying the Genetic Correlation between Multiple Cancer Types.

Authors:  Sara Lindström; Hilary Finucane; Brendan Bulik-Sullivan; Fredrick R Schumacher; Christopher I Amos; Rayjean J Hung; Kristin Rand; Stephen B Gruber; David Conti; Jennifer B Permuth; Hui-Yi Lin; Ellen L Goode; Thomas A Sellers; Laufey T Amundadottir; Rachael Stolzenberg-Solomon; Alison Klein; Gloria Petersen; Harvey Risch; Brian Wolpin; Li Hsu; Jeroen R Huyghe; Jenny Chang-Claude; Andrew Chan; Sonja Berndt; Rosalind Eeles; Douglas Easton; Christopher A Haiman; David J Hunter; Benjamin Neale; Alkes L Price; Peter Kraft
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2017-06-21       Impact factor: 4.254

Review 9.  The OncoArray Consortium: A Network for Understanding the Genetic Architecture of Common Cancers.

Authors:  Christopher I Amos; Joe Dennis; Zhaoming Wang; Jinyoung Byun; Fredrick R Schumacher; Simon A Gayther; Graham Casey; David J Hunter; Thomas A Sellers; Stephen B Gruber; Alison M Dunning; Kyriaki Michailidou; Laura Fachal; Kimberly Doheny; Amanda B Spurdle; Yafang Li; Xiangjun Xiao; Jane Romm; Elizabeth Pugh; Gerhard A Coetzee; Dennis J Hazelett; Stig E Bojesen; Charlisse Caga-Anan; Christopher A Haiman; Ahsan Kamal; Craig Luccarini; Daniel Tessier; Daniel Vincent; François Bacot; David J Van Den Berg; Stefanie Nelson; Stephen Demetriades; David E Goldgar; Fergus J Couch; Judith L Forman; Graham G Giles; David V Conti; Heike Bickeböller; Angela Risch; Melanie Waldenberger; Irene Brüske-Hohlfeld; Belynda D Hicks; Hua Ling; Lesley McGuffog; Andrew Lee; Karoline Kuchenbaecker; Penny Soucy; Judith Manz; Julie M Cunningham; Katja Butterbach; Zsofia Kote-Jarai; Peter Kraft; Liesel FitzGerald; Sara Lindström; Marcia Adams; James D McKay; Catherine M Phelan; Sara Benlloch; Linda E Kelemen; Paul Brennan; Marjorie Riggan; Tracy A O'Mara; Hongbing Shen; Yongyong Shi; Deborah J Thompson; Marc T Goodman; Sune F Nielsen; Andrew Berchuck; Sylvie Laboissiere; Stephanie L Schmit; Tameka Shelford; Christopher K Edlund; Jack A Taylor; John K Field; Sue K Park; Kenneth Offit; Mads Thomassen; Rita Schmutzler; Laura Ottini; Rayjean J Hung; Jonathan Marchini; Ali Amin Al Olama; Ulrike Peters; Rosalind A Eeles; Michael F Seldin; Elizabeth Gillanders; Daniela Seminara; Antonis C Antoniou; Paul D P Pharoah; Georgia Chenevix-Trench; Stephen J Chanock; Jacques Simard; Douglas F Easton
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2016-10-03       Impact factor: 4.254

10.  Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use.

Authors:  Mengzhen Liu; Yu Jiang; Robbee Wedow; Yue Li; David M Brazel; Fang Chen; Gargi Datta; Jose Davila-Velderrain; Daniel McGuire; Chao Tian; Xiaowei Zhan; Hélène Choquet; Anna R Docherty; Jessica D Faul; Johanna R Foerster; Lars G Fritsche; Maiken Elvestad Gabrielsen; Scott D Gordon; Jeffrey Haessler; Jouke-Jan Hottenga; Hongyan Huang; Seon-Kyeong Jang; Philip R Jansen; Yueh Ling; Reedik Mägi; Nana Matoba; George McMahon; Antonella Mulas; Valeria Orrù; Teemu Palviainen; Anita Pandit; Gunnar W Reginsson; Anne Heidi Skogholt; Jennifer A Smith; Amy E Taylor; Constance Turman; Gonneke Willemsen; Hannah Young; Kendra A Young; Gregory J M Zajac; Wei Zhao; Wei Zhou; Gyda Bjornsdottir; Jason D Boardman; Michael Boehnke; Dorret I Boomsma; Chu Chen; Francesco Cucca; Gareth E Davies; Charles B Eaton; Marissa A Ehringer; Tõnu Esko; Edoardo Fiorillo; Nathan A Gillespie; Daniel F Gudbjartsson; Toomas Haller; Kathleen Mullan Harris; Andrew C Heath; John K Hewitt; Ian B Hickie; John E Hokanson; Christian J Hopfer; David J Hunter; William G Iacono; Eric O Johnson; Yoichiro Kamatani; Sharon L R Kardia; Matthew C Keller; Manolis Kellis; Charles Kooperberg; Peter Kraft; Kenneth S Krauter; Markku Laakso; Penelope A Lind; Anu Loukola; Sharon M Lutz; Pamela A F Madden; Nicholas G Martin; Matt McGue; Matthew B McQueen; Sarah E Medland; Andres Metspalu; Karen L Mohlke; Jonas B Nielsen; Yukinori Okada; Ulrike Peters; Tinca J C Polderman; Danielle Posthuma; Alexander P Reiner; John P Rice; Eric Rimm; Richard J Rose; Valgerdur Runarsdottir; Michael C Stallings; Alena Stančáková; Hreinn Stefansson; Khanh K Thai; Hilary A Tindle; Thorarinn Tyrfingsson; Tamara L Wall; David R Weir; Constance Weisner; John B Whitfield; Bendik Slagsvold Winsvold; Jie Yin; Luisa Zuccolo; Laura J Bierut; Kristian Hveem; James J Lee; Marcus R Munafò; Nancy L Saccone; Cristen J Willer; Marilyn C Cornelis; Sean P David; David A Hinds; Eric Jorgenson; Jaakko Kaprio; Jerry A Stitzel; Kari Stefansson; Thorgeir E Thorgeirsson; Gonçalo Abecasis; Dajiang J Liu; Scott Vrieze
Journal:  Nat Genet       Date:  2019-01-14       Impact factor: 38.330
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  1 in total

1.  Shared genomic architecture between COVID-19 severity and numerous clinical and physiologic parameters revealed by LD score regression analysis.

Authors:  Jinyoung Byun; Younghun Han; Kyle M Walsh; Amy S Park; Melissa L Bondy; Christopher I Amos
Journal:  Sci Rep       Date:  2022-02-03       Impact factor: 4.379
  1 in total

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