Literature DB >> 28637796

Quantifying the Genetic Correlation between Multiple Cancer Types.

Sara Lindström1,2, Hilary Finucane3,4, Brendan Bulik-Sullivan5, Fredrick R Schumacher6,7, Christopher I Amos8, Rayjean J Hung9, Kristin Rand10, Stephen B Gruber10, David Conti10, Jennifer B Permuth11,12, Hui-Yi Lin13, Ellen L Goode14, Thomas A Sellers11, Laufey T Amundadottir15, Rachael Stolzenberg-Solomon15, Alison Klein16,17, Gloria Petersen14, Harvey Risch18, Brian Wolpin19,20, Li Hsu2, Jeroen R Huyghe2, Jenny Chang-Claude21,22, Andrew Chan23, Sonja Berndt15, Rosalind Eeles24, Douglas Easton25, Christopher A Haiman10, David J Hunter3,26, Benjamin Neale5, Alkes L Price3, Peter Kraft3,27.   

Abstract

Background: Many cancers share specific genetic risk factors, including both rare high-penetrance mutations and common SNPs identified through genome-wide association studies (GWAS). However, little is known about the overall shared heritability across cancers. Quantifying the extent to which two distinct cancers share genetic origin will give insights to shared biological mechanisms underlying cancer and inform design for future genetic association studies.
Methods: In this study, we estimated the pair-wise genetic correlation between six cancer types (breast, colorectal, lung, ovarian, pancreatic, and prostate) using cancer-specific GWAS summary statistics data based on 66,958 case and 70,665 control subjects of European ancestry. We also estimated genetic correlations between cancers and 14 noncancer diseases and traits.
Results: After adjusting for 15 pair-wise genetic correlation tests between cancers, we found significant (P < 0.003) genetic correlations between pancreatic and colorectal cancer (rg = 0.55, P = 0.003), lung and colorectal cancer (rg = 0.31, P = 0.001). We also found suggestive genetic correlations between lung and breast cancer (rg = 0.27, P = 0.009), and colorectal and breast cancer (rg = 0.22, P = 0.01). In contrast, we found no evidence that prostate cancer shared an appreciable proportion of heritability with other cancers. After adjusting for 84 tests studying genetic correlations between cancer types and other traits (Bonferroni-corrected P value: 0.0006), only the genetic correlation between lung cancer and smoking remained significant (rg = 0.41, P = 1.03 × 10-6). We also observed nominally significant genetic correlations between body mass index and all cancers except ovarian cancer.Conclusions: Our results highlight novel genetic correlations and lend support to previous observational studies that have observed links between cancers and risk factors.Impact: This study demonstrates modest genetic correlations between cancers; in particular, breast, colorectal, and lung cancer share some degree of genetic basis. Cancer Epidemiol Biomarkers Prev; 26(9); 1427-35. ©2017 AACR. ©2017 American Association for Cancer Research.

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Mesh：

Year:  2017        PMID： 28637796      PMCID： PMC5582139          DOI： 10.1158/1055-9965.EPI-17-0211

Source DB:  PubMed          Journal:  Cancer Epidemiol Biomarkers Prev        ISSN： 1055-9965            Impact factor:   4.254


  57 in total

1.  Multiple prostate cancer risk variants on 8q24.

Authors:  John S Witte
Journal:  Nat Genet       Date:  2007-05       Impact factor: 38.330

Review 2.  Family history is a significant risk factor for pancreatic cancer: results from a systematic review and meta-analysis.

Authors:  Jennifer Permuth-Wey; Kathleen M Egan
Journal:  Fam Cancer       Date:  2008-09-02       Impact factor: 2.375

3.  Increased Incidence of Second Primary Pancreatic Cancer in Patients with Prior Colorectal Cancer: A Population-Based US Study.

Authors:  Erik Rahimi; Sachin Batra; Nirav Thosani; Harminder Singh; Sushovan Guha
Journal:  Dig Dis Sci       Date:  2016-04-23       Impact factor: 3.199

4.  Common SNPs explain a large proportion of the heritability for human height.

Authors:  Jian Yang; Beben Benyamin; Brian P McEvoy; Scott Gordon; Anjali K Henders; Dale R Nyholt; Pamela A Madden; Andrew C Heath; Nicholas G Martin; Grant W Montgomery; Michael E Goddard; Peter M Visscher
Journal:  Nat Genet       Date:  2010-06-20       Impact factor: 38.330

5.  Multiple independent loci at chromosome 15q25.1 affect smoking quantity: a meta-analysis and comparison with lung cancer and COPD.

Authors:  Nancy L Saccone; Robert C Culverhouse; Tae-Hwi Schwantes-An; Dale S Cannon; Xiangning Chen; Sven Cichon; Ina Giegling; Shizhong Han; Younghun Han; Kaisu Keskitalo-Vuokko; Xiangyang Kong; Maria Teresa Landi; Jennie Z Ma; Susan E Short; Sarah H Stephens; Victoria L Stevens; Lingwei Sun; Yufei Wang; Angela S Wenzlaff; Steven H Aggen; Naomi Breslau; Peter Broderick; Nilanjan Chatterjee; Jingchun Chen; Andrew C Heath; Markku Heliövaara; Nicole R Hoft; David J Hunter; Majken K Jensen; Nicholas G Martin; Grant W Montgomery; Tianhua Niu; Thomas J Payne; Leena Peltonen; Michele L Pergadia; John P Rice; Richard Sherva; Margaret R Spitz; Juzhong Sun; Jen C Wang; Robert B Weiss; William Wheeler; Stephanie H Witt; Bao-Zhu Yang; Neil E Caporaso; Marissa A Ehringer; Tim Eisen; Susan M Gapstur; Joel Gelernter; Richard Houlston; Jaakko Kaprio; Kenneth S Kendler; Peter Kraft; Mark F Leppert; Ming D Li; Pamela A F Madden; Markus M Nöthen; Sreekumar Pillai; Marcella Rietschel; Dan Rujescu; Ann Schwartz; Christopher I Amos; Laura J Bierut
Journal:  PLoS Genet       Date:  2010-08-05       Impact factor: 5.917

6.  Mendelian randomization study of adiposity-related traits and risk of breast, ovarian, prostate, lung and colorectal cancer.

Authors:  Chi Gao; Chirag J Patel; Kyriaki Michailidou; Ulrike Peters; Jian Gong; Joellen Schildkraut; Fredrick R Schumacher; Wei Zheng; Paolo Boffetta; Isabelle Stucker; Walter Willett; Stephen Gruber; Douglas F Easton; David J Hunter; Thomas A Sellers; Christopher Haiman; Brian E Henderson; Rayjean J Hung; Christopher Amos; Brandon L Pierce; Sara Lindström; Peter Kraft
Journal:  Int J Epidemiol       Date:  2016-07-17       Impact factor: 7.196

7.  Association of type 2 diabetes susceptibility variants with advanced prostate cancer risk in the Breast and Prostate Cancer Cohort Consortium.

Authors:  Mitchell J Machiela; Sara Lindström; Naomi E Allen; Christopher A Haiman; Demetrius Albanes; Aurelio Barricarte; Sonja I Berndt; H Bas Bueno-de-Mesquita; Stephen Chanock; J Michael Gaziano; Susan M Gapstur; Edward Giovannucci; Brian E Henderson; Eric J Jacobs; Laurence N Kolonel; Vittorio Krogh; Jing Ma; Meir J Stampfer; Victoria L Stevens; Daniel O Stram; Anne Tjønneland; Ruth Travis; Walter C Willett; David J Hunter; Loic Le Marchand; Peter Kraft
Journal:  Am J Epidemiol       Date:  2012-11-28       Impact factor: 4.897

8.  The causal relevance of body mass index in different histological types of lung cancer: A Mendelian randomization study.

Authors:  Robert Carreras-Torres; Philip C Haycock; Caroline L Relton; Richard M Martin; George Davey Smith; Peter Kraft; Chi Gao; Shelley Tworoger; Loïc Le Marchand; Lynne R Wilkens; Sungshim L Park; Christopher Haiman; John K Field; Michael Davies; Michael Marcus; Geoffrey Liu; Neil E Caporaso; David C Christiani; Yongyue Wei; Chu Chen; Jennifer A Doherty; Gianluca Severi; Gary E Goodman; Rayjean J Hung; Christopher I Amos; James McKay; Mattias Johansson; Paul Brennan
Journal:  Sci Rep       Date:  2016-08-04       Impact factor: 4.379

9.  Genetic relationship between five psychiatric disorders estimated from genome-wide SNPs.

Authors:  S Hong Lee; Stephan Ripke; Benjamin M Neale; Stephen V Faraone; Shaun M Purcell; Roy H Perlis; Bryan J Mowry; Anita Thapar; Michael E Goddard; John S Witte; Devin Absher; Ingrid Agartz; Huda Akil; Farooq Amin; Ole A Andreassen; Adebayo Anjorin; Richard Anney; Verneri Anttila; Dan E Arking; Philip Asherson; Maria H Azevedo; Lena Backlund; Judith A Badner; Anthony J Bailey; Tobias Banaschewski; Jack D Barchas; Michael R Barnes; Thomas B Barrett; Nicholas Bass; Agatino Battaglia; Michael Bauer; Mònica Bayés; Frank Bellivier; Sarah E Bergen; Wade Berrettini; Catalina Betancur; Thomas Bettecken; Joseph Biederman; Elisabeth B Binder; Donald W Black; Douglas H R Blackwood; Cinnamon S Bloss; Michael Boehnke; Dorret I Boomsma; Gerome Breen; René Breuer; Richard Bruggeman; Paul Cormican; Nancy G Buccola; Jan K Buitelaar; William E Bunney; Joseph D Buxbaum; William F Byerley; Enda M Byrne; Sian Caesar; Wiepke Cahn; Rita M Cantor; Miguel Casas; Aravinda Chakravarti; Kimberly Chambert; Khalid Choudhury; Sven Cichon; C Robert Cloninger; David A Collier; Edwin H Cook; Hilary Coon; Bru Cormand; Aiden Corvin; William H Coryell; David W Craig; Ian W Craig; Jennifer Crosbie; Michael L Cuccaro; David Curtis; Darina Czamara; Susmita Datta; Geraldine Dawson; Richard Day; Eco J De Geus; Franziska Degenhardt; Srdjan Djurovic; Gary J Donohoe; Alysa E Doyle; Jubao Duan; Frank Dudbridge; Eftichia Duketis; Richard P Ebstein; Howard J Edenberg; Josephine Elia; Sean Ennis; Bruno Etain; Ayman Fanous; Anne E Farmer; I Nicol Ferrier; Matthew Flickinger; Eric Fombonne; Tatiana Foroud; Josef Frank; Barbara Franke; Christine Fraser; Robert Freedman; Nelson B Freimer; Christine M Freitag; Marion Friedl; Louise Frisén; Louise Gallagher; Pablo V Gejman; Lyudmila Georgieva; Elliot S Gershon; Daniel H Geschwind; Ina Giegling; Michael Gill; Scott D Gordon; Katherine Gordon-Smith; Elaine K Green; Tiffany A Greenwood; Dorothy E Grice; Magdalena Gross; Detelina Grozeva; Weihua Guan; Hugh Gurling; Lieuwe De Haan; Jonathan L Haines; Hakon Hakonarson; Joachim Hallmayer; Steven P Hamilton; Marian L Hamshere; Thomas F Hansen; Annette M Hartmann; Martin Hautzinger; Andrew C Heath; Anjali K Henders; Stefan Herms; Ian B Hickie; Maria Hipolito; Susanne Hoefels; Peter A Holmans; Florian Holsboer; Witte J Hoogendijk; Jouke-Jan Hottenga; Christina M Hultman; Vanessa Hus; Andrés Ingason; Marcus Ising; Stéphane Jamain; Edward G Jones; Ian Jones; Lisa Jones; Jung-Ying Tzeng; Anna K Kähler; René S Kahn; Radhika Kandaswamy; Matthew C Keller; James L Kennedy; Elaine Kenny; Lindsey Kent; Yunjung Kim; George K Kirov; Sabine M Klauck; Lambertus Klei; James A Knowles; Martin A Kohli; Daniel L Koller; Bettina Konte; Ania Korszun; Lydia Krabbendam; Robert Krasucki; Jonna Kuntsi; Phoenix Kwan; Mikael Landén; Niklas Långström; Mark Lathrop; Jacob Lawrence; William B Lawson; Marion Leboyer; David H Ledbetter; Phil H Lee; Todd Lencz; Klaus-Peter Lesch; Douglas F Levinson; Cathryn M Lewis; Jun Li; Paul Lichtenstein; Jeffrey A Lieberman; Dan-Yu Lin; Don H Linszen; Chunyu Liu; Falk W Lohoff; Sandra K Loo; Catherine Lord; Jennifer K Lowe; Susanne Lucae; Donald J MacIntyre; Pamela A F Madden; Elena Maestrini; Patrik K E Magnusson; Pamela B Mahon; Wolfgang Maier; Anil K Malhotra; Shrikant M Mane; Christa L Martin; Nicholas G Martin; Manuel Mattheisen; Keith Matthews; Morten Mattingsdal; Steven A McCarroll; Kevin A McGhee; James J McGough; Patrick J McGrath; Peter McGuffin; Melvin G McInnis; Andrew McIntosh; Rebecca McKinney; Alan W McLean; Francis J McMahon; William M McMahon; Andrew McQuillin; Helena Medeiros; Sarah E Medland; Sandra Meier; Ingrid Melle; Fan Meng; Jobst Meyer; Christel M Middeldorp; Lefkos Middleton; Vihra Milanova; Ana Miranda; Anthony P Monaco; Grant W Montgomery; Jennifer L Moran; Daniel Moreno-De-Luca; Gunnar Morken; Derek W Morris; Eric M Morrow; Valentina Moskvina; Pierandrea Muglia; Thomas W Mühleisen; Walter J Muir; Bertram Müller-Myhsok; Michael Murtha; Richard M Myers; Inez Myin-Germeys; Michael C Neale; Stan F Nelson; Caroline M Nievergelt; Ivan Nikolov; Vishwajit Nimgaonkar; Willem A Nolen; Markus M Nöthen; John I Nurnberger; Evaristus A Nwulia; Dale R Nyholt; Colm O'Dushlaine; Robert D Oades; Ann Olincy; Guiomar Oliveira; Line Olsen; Roel A Ophoff; Urban Osby; Michael J Owen; Aarno Palotie; Jeremy R Parr; Andrew D Paterson; Carlos N Pato; Michele T Pato; Brenda W Penninx; Michele L Pergadia; Margaret A Pericak-Vance; Benjamin S Pickard; Jonathan Pimm; Joseph Piven; Danielle Posthuma; James B Potash; Fritz Poustka; Peter Propping; Vinay Puri; Digby J Quested; Emma M Quinn; Josep Antoni Ramos-Quiroga; Henrik B Rasmussen; Soumya Raychaudhuri; Karola Rehnström; Andreas Reif; Marta Ribasés; John P Rice; Marcella Rietschel; Kathryn Roeder; Herbert Roeyers; Lizzy Rossin; Aribert Rothenberger; Guy Rouleau; Douglas Ruderfer; Dan Rujescu; Alan R Sanders; Stephan J Sanders; Susan L Santangelo; Joseph A Sergeant; Russell Schachar; Martin Schalling; Alan F Schatzberg; William A Scheftner; Gerard D Schellenberg; Stephen W Scherer; Nicholas J Schork; Thomas G Schulze; Johannes Schumacher; Markus Schwarz; Edward Scolnick; Laura J Scott; Jianxin Shi; Paul D Shilling; Stanley I Shyn; Jeremy M Silverman; Susan L Slager; Susan L Smalley; Johannes H Smit; Erin N Smith; Edmund J S Sonuga-Barke; David St Clair; Matthew State; Michael Steffens; Hans-Christoph Steinhausen; John S Strauss; Jana Strohmaier; T Scott Stroup; James S Sutcliffe; Peter Szatmari; Szabocls Szelinger; Srinivasa Thirumalai; Robert C Thompson; Alexandre A Todorov; Federica Tozzi; Jens Treutlein; Manfred Uhr; Edwin J C G van den Oord; Gerard Van Grootheest; Jim Van Os; Astrid M Vicente; Veronica J Vieland; John B Vincent; Peter M Visscher; Christopher A Walsh; Thomas H Wassink; Stanley J Watson; Myrna M Weissman; Thomas Werge; Thomas F Wienker; Ellen M Wijsman; Gonneke Willemsen; Nigel Williams; A Jeremy Willsey; Stephanie H Witt; Wei Xu; Allan H Young; Timothy W Yu; Stanley Zammit; Peter P Zandi; Peng Zhang; Frans G Zitman; Sebastian Zöllner; Bernie Devlin; John R Kelsoe; Pamela Sklar; Mark J Daly; Michael C O'Donovan; Nicholas Craddock; Patrick F Sullivan; Jordan W Smoller; Kenneth S Kendler; Naomi R Wray
Journal:  Nat Genet       Date:  2013-08-11       Impact factor: 38.330

10.  Cross-Cancer Genome-Wide Analysis of Lung, Ovary, Breast, Prostate, and Colorectal Cancer Reveals Novel Pleiotropic Associations.

Authors:  Gordon Fehringer; Peter Kraft; Paul D Pharoah; Rosalind A Eeles; Nilanjan Chatterjee; Fredrick R Schumacher; Joellen M Schildkraut; Sara Lindström; Paul Brennan; Heike Bickeböller; Richard S Houlston; Maria Teresa Landi; Neil Caporaso; Angela Risch; Ali Amin Al Olama; Sonja I Berndt; Edward L Giovannucci; Henrik Grönberg; Zsofia Kote-Jarai; Jing Ma; Kenneth Muir; Meir J Stampfer; Victoria L Stevens; Fredrik Wiklund; Walter C Willett; Ellen L Goode; Jennifer B Permuth; Harvey A Risch; Brett M Reid; Stephane Bezieau; Hermann Brenner; Andrew T Chan; Jenny Chang-Claude; Thomas J Hudson; Jonathan K Kocarnik; Polly A Newcomb; Robert E Schoen; Martha L Slattery; Emily White; Muriel A Adank; Habibul Ahsan; Kristiina Aittomäki; Laura Baglietto; Carl Blomquist; Federico Canzian; Kamila Czene; Isabel Dos-Santos-Silva; A Heather Eliassen; Jonine D Figueroa; Dieter Flesch-Janys; Olivia Fletcher; Montserrat Garcia-Closas; Mia M Gaudet; Nichola Johnson; Per Hall; Aditi Hazra; Rebecca Hein; Albert Hofman; John L Hopper; Astrid Irwanto; Mattias Johansson; Rudolf Kaaks; Muhammad G Kibriya; Peter Lichtner; Jianjun Liu; Eiliv Lund; Enes Makalic; Alfons Meindl; Bertram Müller-Myhsok; Taru A Muranen; Heli Nevanlinna; Petra H Peeters; Julian Peto; Ross L Prentice; Nazneen Rahman; Maria Jose Sanchez; Daniel F Schmidt; Rita K Schmutzler; Melissa C Southey; Rulla Tamimi; Ruth C Travis; Clare Turnbull; Andre G Uitterlinden; Zhaoming Wang; Alice S Whittemore; Xiaohong R Yang; Wei Zheng; Daniel D Buchanan; Graham Casey; David V Conti; Christopher K Edlund; Steven Gallinger; Robert W Haile; Mark Jenkins; Loïc Le Marchand; Li Li; Noralene M Lindor; Stephanie L Schmit; Stephen N Thibodeau; Michael O Woods; Thorunn Rafnar; Julius Gudmundsson; Simon N Stacey; Kari Stefansson; Patrick Sulem; Y Ann Chen; Jonathan P Tyrer; David C Christiani; Yongyue Wei; Hongbing Shen; Zhibin Hu; Xiao-Ou Shu; Kouya Shiraishi; Atsushi Takahashi; Yohan Bossé; Ma'en Obeidat; David Nickle; Wim Timens; Matthew L Freedman; Qiyuan Li; Daniela Seminara; Stephen J Chanock; Jian Gong; Ulrike Peters; Stephen B Gruber; Christopher I Amos; Thomas A Sellers; Douglas F Easton; David J Hunter; Christopher A Haiman; Brian E Henderson; Rayjean J Hung
Journal:  Cancer Res       Date:  2016-04-20       Impact factor: 12.701
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  19 in total

1.  Association of Pancreatic Cancer Susceptibility Variants with Risk of Breast Cancer in Women of European and African Ancestry.

Authors:  Shengfeng Wang; Yonglan Zheng; Temidayo O Ogundiran; Oladosu Ojengbede; Wei Zheng; Katherine L Nathanson; Barbara Nemesure; Stefan Ambs; Olufunmilayo I Olopade; Dezheng Huo
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2017-12-18       Impact factor: 4.254

2.  Considering hormone-sensitive cancers as a single disease in the UK biobank reveals shared aetiology.

Authors:  Muktar Ahmed; Ville-Petteri Mäkinen; Anwar Mulugeta; Jisu Shin; Terry Boyle; Elina Hyppönen; Sang Hong Lee
Journal:  Commun Biol       Date:  2022-06-21

3.  Is Schizophrenia a Risk Factor for Breast Cancer?-Evidence From Genetic Data.

Authors:  Enda M Byrne; Manuel A R Ferreira; Angli Xue; Sara Lindström; Xia Jiang; Jian Yang; Douglas F Easton; Naomi R Wray; Georgia Chenevix-Trench
Journal:  Schizophr Bull       Date:  2019-10-24       Impact factor: 9.306

4.  Association between inflammatory bowel disease and prostate cancer: A large-scale, prospective, population-based study.

Authors:  Travis J Meyers; Adam B Weiner; Rebecca E Graff; Anuj S Desai; Lauren Folgosa Cooley; William J Catalona; Stephen B Hanauer; Jennifer D Wu; Edward M Schaeffer; Sarki A Abdulkadir; Shilajit D Kundu; John S Witte
Journal:  Int J Cancer       Date:  2020-05-29       Impact factor: 7.396

5.  The Shared Genetic Architectures Between Lung Cancer and Multiple Polygenic Phenotypes in Genome-Wide Association Studies.

Authors:  Jinyoung Byun; Younghun Han; Quinn T Ostrom; Jacob Edelson; Kyle M Walsh; Rowland W Pettit; Melissa L Bondy; Rayjean J Hung; James D McKay; Christopher I Amos
Journal:  Cancer Epidemiol Biomarkers Prev       Date:  2021-03-26       Impact factor: 4.090

6.  Genetic susceptibility markers for a breast-colorectal cancer phenotype: Exploratory results from genome-wide association studies.

Authors:  Mala Pande; Aron Joon; Abenaa M Brewster; Wei V Chen; John L Hopper; Cathy Eng; Sanjay Shete; Graham Casey; Fredrick Schumacher; Yi Lin; Tabitha A Harrison; Emily White; Habibul Ahsan; Irene L Andrulis; Alice S Whittemore; Esther M John; Aung Ko Win; Enes Makalic; Daniel F Schmidt; Miroslaw K Kapuscinski; Heather M Ochs-Balcom; Steven Gallinger; Mark A Jenkins; Polly A Newcomb; Noralane M Lindor; Ulrike Peters; Christopher I Amos; Patrick M Lynch
Journal:  PLoS One       Date:  2018-04-26       Impact factor: 3.240

7.  The relationship between circulating lipids and breast cancer risk: A Mendelian randomization study.

Authors:  Kelsey E Johnson; Katherine M Siewert; Derek Klarin; Scott M Damrauer; Kyong-Mi Chang; Philip S Tsao; Themistocles L Assimes; Kara N Maxwell; Benjamin F Voight
Journal:  PLoS Med       Date:  2020-09-11       Impact factor: 11.069

8.  Shared heritability and functional enrichment across six solid cancers.

Authors:  Xia Jiang; Hilary K Finucane; Fredrick R Schumacher; Stephanie L Schmit; Jonathan P Tyrer; Younghun Han; Kyriaki Michailidou; Corina Lesseur; Karoline B Kuchenbaecker; Joe Dennis; David V Conti; Graham Casey; Mia M Gaudet; Jeroen R Huyghe; Demetrius Albanes; Melinda C Aldrich; Angeline S Andrew; Irene L Andrulis; Hoda Anton-Culver; Antonis C Antoniou; Natalia N Antonenkova; Susanne M Arnold; Kristan J Aronson; Banu K Arun; Elisa V Bandera; Rosa B Barkardottir; Daniel R Barnes; Jyotsna Batra; Matthias W Beckmann; Javier Benitez; Sara Benlloch; Andrew Berchuck; Sonja I Berndt; Heike Bickeböller; Stephanie A Bien; Carl Blomqvist; Stefania Boccia; Natalia V Bogdanova; Stig E Bojesen; Manjeet K Bolla; Hiltrud Brauch; Hermann Brenner; James D Brenton; Mark N Brook; Joan Brunet; Hans Brunnström; Daniel D Buchanan; Barbara Burwinkel; Ralf Butzow; Gabriella Cadoni; Trinidad Caldés; Maria A Caligo; Ian Campbell; Peter T Campbell; Géraldine Cancel-Tassin; Lisa Cannon-Albright; Daniele Campa; Neil Caporaso; André L Carvalho; Andrew T Chan; Jenny Chang-Claude; Stephen J Chanock; Chu Chen; David C Christiani; Kathleen B M Claes; Frank Claessens; Judith Clements; J Margriet Collée; Marcia Cruz Correa; Fergus J Couch; Angela Cox; Julie M Cunningham; Cezary Cybulski; Kamila Czene; Mary B Daly; Anna deFazio; Peter Devilee; Orland Diez; Manuela Gago-Dominguez; Jenny L Donovan; Thilo Dörk; Eric J Duell; Alison M Dunning; Miriam Dwek; Diana M Eccles; Christopher K Edlund; Digna R Velez Edwards; Carolina Ellberg; D Gareth Evans; Peter A Fasching; Robert L Ferris; Triantafillos Liloglou; Jane C Figueiredo; Olivia Fletcher; Renée T Fortner; Florentia Fostira; Silvia Franceschi; Eitan Friedman; Steven J Gallinger; Patricia A Ganz; Judy Garber; José A García-Sáenz; Simon A Gayther; Graham G Giles; Andrew K Godwin; Mark S Goldberg; David E Goldgar; Ellen L Goode; Marc T Goodman; Gary Goodman; Kjell Grankvist; Mark H Greene; Henrik Gronberg; Jacek Gronwald; Pascal Guénel; Niclas Håkansson; Per Hall; Ute Hamann; Freddie C Hamdy; Robert J Hamilton; Jochen Hampe; Aage Haugen; Florian Heitz; Rolando Herrero; Peter Hillemanns; Michael Hoffmeister; Estrid Høgdall; Yun-Chul Hong; John L Hopper; Richard Houlston; Peter J Hulick; David J Hunter; David G Huntsman; Gregory Idos; Evgeny N Imyanitov; Sue Ann Ingles; Claudine Isaacs; Anna Jakubowska; Paul James; Mark A Jenkins; Mattias Johansson; Mikael Johansson; Esther M John; Amit D Joshi; Radka Kaneva; Beth Y Karlan; Linda E Kelemen; Tabea Kühl; Kay-Tee Khaw; Elza Khusnutdinova; Adam S Kibel; Lambertus A Kiemeney; Jeri Kim; Susanne K Kjaer; Julia A Knight; Manolis Kogevinas; Zsofia Kote-Jarai; Stella Koutros; Vessela N Kristensen; Jolanta Kupryjanczyk; Martin Lacko; Stephan Lam; Diether Lambrechts; Maria Teresa Landi; Philip Lazarus; Nhu D Le; Eunjung Lee; Flavio Lejbkowicz; Heinz-Josef Lenz; Goska Leslie; Davor Lessel; Jenny Lester; Douglas A Levine; Li Li; Christopher I Li; Annika Lindblom; Noralane M Lindor; Geoffrey Liu; Fotios Loupakis; Jan Lubiński; Lovise Maehle; Christiane Maier; Arto Mannermaa; Loic Le Marchand; Sara Margolin; Taymaa May; Lesley McGuffog; Alfons Meindl; Pooja Middha; Austin Miller; Roger L Milne; Robert J MacInnis; Francesmary Modugno; Marco Montagna; Victor Moreno; Kirsten B Moysich; Lorelei Mucci; Kenneth Muir; Anna Marie Mulligan; Katherine L Nathanson; David E Neal; Andrew R Ness; Susan L Neuhausen; Heli Nevanlinna; Polly A Newcomb; Lisa F Newcomb; Finn Cilius Nielsen; Liene Nikitina-Zake; Børge G Nordestgaard; Robert L Nussbaum; Kenneth Offit; Edith Olah; Ali Amin Al Olama; Olufunmilayo I Olopade; Andrew F Olshan; Håkan Olsson; Ana Osorio; Hardev Pandha; Jong Y Park; Nora Pashayan; Michael T Parsons; Tanja Pejovic; Kathryn L Penney; Wilbert H M Peters; Catherine M Phelan; Amanda I Phipps; Dijana Plaseska-Karanfilska; Miranda Pring; Darya Prokofyeva; Paolo Radice; Kari Stefansson; Susan J Ramus; Leon Raskin; Gad Rennert; Hedy S Rennert; Elizabeth J van Rensburg; Marjorie J Riggan; Harvey A Risch; Angela Risch; Monique J Roobol; Barry S Rosenstein; Mary Anne Rossing; Kim De Ruyck; Emmanouil Saloustros; Dale P Sandler; Elinor J Sawyer; Matthew B Schabath; Johanna Schleutker; Marjanka K Schmidt; V Wendy Setiawan; Hongbing Shen; Erin M Siegel; Weiva Sieh; Christian F Singer; Martha L Slattery; Karina Dalsgaard Sorensen; Melissa C Southey; Amanda B Spurdle; Janet L Stanford; Victoria L Stevens; Sebastian Stintzing; Jennifer Stone; Karin Sundfeldt; Rebecca Sutphen; Anthony J Swerdlow; Eloiza H Tajara; Catherine M Tangen; Adonina Tardon; Jack A Taylor; M Dawn Teare; Manuel R Teixeira; Mary Beth Terry; Kathryn L Terry; Stephen N Thibodeau; Mads Thomassen; Line Bjørge; Marc Tischkowitz; Amanda E Toland; Diana Torres; Paul A Townsend; Ruth C Travis; Nadine Tung; Shelley S Tworoger; Cornelia M Ulrich; Nawaid Usmani; Celine M Vachon; Els Van Nieuwenhuysen; Ana Vega; Miguel Elías Aguado-Barrera; Qin Wang; Penelope M Webb; Clarice R Weinberg; Stephanie Weinstein; Mark C Weissler; Jeffrey N Weitzel; Catharine M L West; Emily White; Alice S Whittemore; H-Erich Wichmann; Fredrik Wiklund; Robert Winqvist; Alicja Wolk; Penella Woll; Michael Woods; Anna H Wu; Xifeng Wu; Drakoulis Yannoukakos; Wei Zheng; Shanbeh Zienolddiny; Argyrios Ziogas; Kristin K Zorn; Jacqueline M Lane; Richa Saxena; Duncan Thomas; Rayjean J Hung; Brenda Diergaarde; James McKay; Ulrike Peters; Li Hsu; Montserrat García-Closas; Rosalind A Eeles; Georgia Chenevix-Trench; Paul J Brennan; Christopher A Haiman; Jacques Simard; Douglas F Easton; Stephen B Gruber; Paul D P Pharoah; Alkes L Price; Bogdan Pasaniuc; Christopher I Amos; Peter Kraft; Sara Lindström
Journal:  Nat Commun       Date:  2019-01-25       Impact factor: 17.694

9.  Genetic Evidence for the Association between Schizophrenia and Breast Cancer.

Authors:  Jiajun Shi; Lang Wu; Wei Zheng; Wanqing Wen; Shuyang Wang; Xiang Shu; Jirong Long; Chen-Yang Shen; Pei-Ei Wu; Emmanouil Saloustros; Jenny Chang-Claude; Hermann Brenner; Xiao-Ou Shu; Qiuyin Cai
Journal:  J Psychiatr Brain Sci       Date:  2018-08-08

10.  Genetic correlation and causal relationships between cardio-metabolic traits and lung function impairment.

Authors:  Matthias Wielscher; Andre F S Amaral; Diana van der Plaat; Louise V Wain; Sylvain Sebert; David Mosen-Ansorena; Juha Auvinen; Karl-Heinz Herzig; Abbas Dehghan; Debbie L Jarvis; Marjo-Riitta Jarvelin
Journal:  Genome Med       Date:  2021-06-21       Impact factor: 11.117
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