Literature DB >> 33720771

Genetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile: A Phenome-Wide Association Study.

Marios K Georgakis1, Rainer Malik1, Xue Li2,3, Dipender Gill4, Michael G Levin5, Ha My T Vy6, Renae Judy7, Marylyn Ritchie8, Shefali S Verma8, Girish N Nadkarni6,9,10, Scott M Damrauer7,11, Evropi Theodoratou2,12, Martin Dichgans1,13,14.   

Abstract

Entities:  

Keywords:  biomarkers; cardiovascular diseases; cholesterol, HDL; diabetes mellitus, type 2; genetics; interleukin-6

Mesh：

Substances：

Year:  2021        PMID： 33720771     DOI： 10.1161/CIRCULATIONAHA.120.052604

Source DB:  PubMed          Journal:  Circulation        ISSN： 0009-7322            Impact factor:   29.690


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  9 in total

1.  Circulating Interleukin-6 Levels and Incident Ischemic Stroke: A Systematic Review and Meta-analysis of Prospective Studies.

Authors:  Andreas Papadopoulos; Konstantinos Palaiopanos; Harry Björkbacka; Annette Peters; James A de Lemos; Sudha Seshadri; Martin Dichgans; Marios K Georgakis
Journal:  Neurology       Date:  2021-12-30       Impact factor: 9.910

2.  A Missense Variant in the IL-6 Receptor and Protection From Peripheral Artery Disease.

Authors:  Michael G Levin; Derek Klarin; Marios K Georgakis; Julie Lynch; Katherine P Liao; Benjamin F Voight; Christopher J O'Donnell; Kyong-Mi Chang; Themistocles L Assimes; Philip S Tsao; Scott M Damrauer
Journal:  Circ Res       Date:  2021-09-22       Impact factor: 17.367

3.  Interleukin-6 Predicts Carotid Plaque Severity, Vulnerability, and Progression.

Authors:  Joseph Kamtchum-Tatuene; Luca Saba; Mirjam R Heldner; Michiel H F Poorthuis; Gert J de Borst; Tatjana Rundek; Stavros K Kakkos; Seemant Chaturvedi; Raffi Topakian; Joseph F Polak; Glen C Jickling
Journal:  Circ Res       Date:  2022-06-17       Impact factor: 23.213

4.  GDF-15 as a Therapeutic Target of Diabetic Complications Increases the Risk of Gallstone Disease: Mendelian Randomization and Polygenic Risk Score Analysis.

Authors:  Lili Yu; Yajing Zhou; Lijuan Wang; Xuan Zhou; Jing Sun; Jiarui Xiao; Xiaolin Xu; Susanna C Larsson; Shuai Yuan; Xue Li
Journal:  Front Genet       Date:  2022-06-13       Impact factor: 4.772

Review 5.  Genetics, Genomics, and Precision Medicine.

Authors:  James F Meschia; Martin Dichgans
Journal:  Stroke       Date:  2021-09-02       Impact factor: 10.170

Review 6.  Interactions Between Kidney Function and Cerebrovascular Disease: Vessel Pathology That Fires Together Wires Together.

Authors:  Sandro Marini; Marios K Georgakis; Christopher D Anderson
Journal:  Front Neurol       Date:  2021-11-24       Impact factor: 4.003

7.  Additive Effects of Genetic Interleukin-6 Signaling Downregulation and Low-Density Lipoprotein Cholesterol Lowering on Cardiovascular Disease: A 2×2 Factorial Mendelian Randomization Analysis.

Authors:  Marios K Georgakis; Rainer Malik; Stephen Burgess; Martin Dichgans
Journal:  J Am Heart Assoc       Date:  2021-12-20       Impact factor: 5.501

8.  Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups.

Authors:  Marios K Georgakis; Rainer Malik; Tom G Richardson; Joanna M M Howson; Christopher D Anderson; Stephen Burgess; G Kees Hovingh; Martin Dichgans; Dipender Gill
Journal:  BMC Med       Date:  2022-08-11       Impact factor: 11.150

9.  Utilizing network pharmacology and experimental validation to investigate the underlying mechanism of phellodendrine on inflammation.

Authors:  Lili Hu; Jue Wang; Na Wu; Xiaoge Zhao; Donghui Cai
Journal:  PeerJ       Date:  2022-09-23       Impact factor: 3.061
  9 in total

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