Literature DB >> 34547901

A Missense Variant in the IL-6 Receptor and Protection From Peripheral Artery Disease.

Michael G Levin1,2,3, Derek Klarin4,5, Marios K Georgakis6,7,8, Julie Lynch9,10, Katherine P Liao11,12,13, Benjamin F Voight14,15,16, Christopher J O'Donnell11,12,13, Kyong-Mi Chang2,3, Themistocles L Assimes17,18,19, Philip S Tsao17,18,19, Scott M Damrauer20,3.   

Abstract

Entities:  

Keywords:  cardiovascular diseases; coronary Artery disease; genetics; inflammation; interleukin-6; mutation; peripheral artery disease

Mesh：

Substances：

Year:  2021        PMID： 34547901      PMCID： PMC8556352          DOI： 10.1161/CIRCRESAHA.121.319589

Source DB:  PubMed          Journal:  Circ Res        ISSN： 0009-7330            Impact factor:   17.367


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  5 in total

1.  Association of Interleukin 6 Receptor Variant With Cardiovascular Disease Effects of Interleukin 6 Receptor Blocking Therapy: A Phenome-Wide Association Study.

Authors:  Tianxi Cai; Yichi Zhang; Yuk-Lam Ho; Nicholas Link; Jiehuan Sun; Jie Huang; Tianrun A Cai; Scott Damrauer; Yuri Ahuja; Jacqueline Honerlaw; Jie Huang; Lauren Costa; Petra Schubert; Chuan Hong; David Gagnon; Yan V Sun; J Michael Gaziano; Peter Wilson; Kelly Cho; Philip Tsao; Christopher J O'Donnell; Katherine P Liao
Journal:  JAMA Cardiol       Date:  2018-09-01       Impact factor: 14.676

2.  Genome-wide association study of peripheral artery disease in the Million Veteran Program.

Authors:  Derek Klarin; Julie Lynch; Krishna Aragam; Mark Chaffin; Themistocles L Assimes; Jie Huang; Kyung Min Lee; Qing Shao; Jennifer E Huffman; Pradeep Natarajan; Shipra Arya; Aeron Small; Yan V Sun; Marijana Vujkovic; Matthew S Freiberg; Lu Wang; Jinbo Chen; Danish Saleheen; Jennifer S Lee; Donald R Miller; Peter Reaven; Patrick R Alba; Olga V Patterson; Scott L DuVall; William E Boden; Joshua A Beckman; J Michael Gaziano; John Concato; Daniel J Rader; Kelly Cho; Kyong-Mi Chang; Peter W F Wilson; Christopher J O'Donnell; Sekar Kathiresan; Philip S Tsao; Scott M Damrauer
Journal:  Nat Med       Date:  2019-07-08       Impact factor: 53.440

Review 3.  Targeting Inflammatory Pathways in Cardiovascular Disease: The Inflammasome, Interleukin-1, Interleukin-6 and Beyond.

Authors:  Peter Libby
Journal:  Cells       Date:  2021-04-20       Impact factor: 6.600

4.  Genetically Downregulated Interleukin-6 Signaling Is Associated With a Favorable Cardiometabolic Profile: A Phenome-Wide Association Study.

Authors:  Marios K Georgakis; Rainer Malik; Xue Li; Dipender Gill; Michael G Levin; Ha My T Vy; Renae Judy; Marylyn Ritchie; Shefali S Verma; Girish N Nadkarni; Scott M Damrauer; Evropi Theodoratou; Martin Dichgans
Journal:  Circulation       Date:  2021-03-15       Impact factor: 29.690

5.  Functional IL6R 358Ala allele impairs classical IL-6 receptor signaling and influences risk of diverse inflammatory diseases.

Authors:  Ricardo C Ferreira; Daniel F Freitag; Antony J Cutler; Joanna M M Howson; Daniel B Rainbow; Deborah J Smyth; Stephen Kaptoge; Pamela Clarke; Charlotte Boreham; Richard M Coulson; Marcin L Pekalski; Wei-Min Chen; Suna Onengut-Gumuscu; Stephen S Rich; Adam S Butterworth; Anders Malarstig; John Danesh; John A Todd
Journal:  PLoS Genet       Date:  2013-04-04       Impact factor: 5.917
  5 in total
  2 in total

1.  Interleukin-6 Predicts Carotid Plaque Severity, Vulnerability, and Progression.

Authors:  Joseph Kamtchum-Tatuene; Luca Saba; Mirjam R Heldner; Michiel H F Poorthuis; Gert J de Borst; Tatjana Rundek; Stavros K Kakkos; Seemant Chaturvedi; Raffi Topakian; Joseph F Polak; Glen C Jickling
Journal:  Circ Res       Date:  2022-06-17       Impact factor: 23.213

2.  Associations of genetically predicted IL-6 signaling with cardiovascular disease risk across population subgroups.

Authors:  Marios K Georgakis; Rainer Malik; Tom G Richardson; Joanna M M Howson; Christopher D Anderson; Stephen Burgess; G Kees Hovingh; Martin Dichgans; Dipender Gill
Journal:  BMC Med       Date:  2022-08-11       Impact factor: 11.150
  2 in total

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