| Literature DB >> 33706862 |
Vítor Borges1,2, Carlos Sousa2,3, Luís Menezes4, António Maia Gonçalves5, Miguel Picão6, José Pedro Almeida7, Margarida Vieita7, Rafael Santos7, Ana Rita Silva3, Mariana Costa3, Luís Carneiro3, Pedro Casaca8, Pedro Pinto-Leite8, André Peralta-Santos8, Joana Isidro1, Sílvia Duarte9, Luís Vieira9, Raquel Guiomar10, Susana Silva11, Baltazar Nunes11, João P Gomes1.
Abstract
We show that the SARS-CoV-2 B.1.1.7 lineage is highly disseminated in Portugal, with the odds of B.1.1.7 proportion increasing at an estimated 89% (95% confidence interval: 83-95%) per week until week 3 2021. RT-PCR spike gene target late detection (SGTL) can constitute a useful surrogate to track B.1.1.7 spread, besides the spike gene target failure (SGTF) proxy. SGTL/SGTF samples were associated with statistically significant higher viral loads, but not with substantial shift in age distribution compared to non-SGTF/SGTL cases.Entities:
Keywords: B.1.1.7 lineage; RT-PCR; SARS-CoV-2; genome sequencing; laboratory surveillance; spike gene target failure (SGTF); spike gene target late detection (SGTL)
Mesh:
Substances:
Year: 2021 PMID: 33706862 PMCID: PMC7953529 DOI: 10.2807/1560-7917.ES.2021.26.10.2100130
Source DB: PubMed Journal: Euro Surveill ISSN: 1025-496X