| Literature DB >> 33580259 |
Michael Kidd1,2, Alex Richter3, Angus Best4, Nicola Cumley4, Jeremy Mirza4, Benita Percival4, Megan Mayhew4, Oliver Megram4, Fiona Ashford4, Thomas White4, Emma Moles-Garcia4, Liam Crawford4, Andrew Bosworth2, Sowsan F Atabani1,2, Tim Plant4, Alan McNally5.
Abstract
A SARS-CoV-2 variant B1.1.7 containing mutation Δ69/70 has spread rapidly in the United Kingdom and shows an identifiable profile in ThermoFisher TaqPath RT-qPCR, S gene target failure (SGTF). We analyzed recent test data for trends and significance. Linked cycle threshold (Ct) values for respiratory samples showed that a low Ct for ORF1ab and N were clearly associated with SGTF. Significantly more SGTF samples had higher inferred viral loads between 1×107 and 1×108. Our conclusion is that patients whose samples exhibit the SGTF profile are more likely to have high viral loads, which may explain higher infectivity and rapidity of spread.Entities:
Keywords: B.1.1.7; COVID-19; Ct values; RT-PCR; S gene dropout; S-variant; SARS-CoV-2; SGTF; TaqPath; VOC-202012/01; viral load; Δ69/70
Year: 2021 PMID： 33580259 PMCID： PMC7928763 DOI： 10.1093/infdis/jiab082
Source DB: PubMed Journal: J Infect Dis ISSN： 0022-1899 Impact factor: 5.226