Majid Mirsadraee1, Bahareh Azmoon2, Shadi Ghaffari3, Aboutaleb Abdolsamadi4, Mohammad Reza Khazdair5. 1. Department of Internal Medicine, Faculty of Medicine, Islamic Azad University, Mashhad Branch, Mashhad, Iran. 2. Innovative Medical Research Center, Faculty of Medicine, Islamic Azad University, Mashhad Branch, Mashhad, Iran. 3. Shahid Hasehemi Nezhad Research Center, Kavosh High School, Ministry of Education, Mashhad, Iran. 4. Independent Pharmacist. 5. Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Abstract
OBJECTIVE: The aims of this study was to determine the effect of Propolis (resinous mixture that honey bees produce by mixing saliva and beeswax) on clinical and physiological findings of moderate persistent asthma. MATERIALS AND METHODS: Fifty-two subjects aged 44.6±18.5 years old with moderate asthma and Forced expiratory volume in 1 second (FEV1) 60-79% of predicted, were enrolled in this clinical trial. We randomly allocated subjects to receive either propolis (75 mg three times a day) or a matched placebo for one month. Primary outcome was Asthma control test (ACT) score and secondary outcomes included dyspnea, spirometry, fractional exhaled nitric oxide (FENO) and sputum cytology including inflammatory cell. Sputum induction was done by hypertonic saline and cytology slides were stained by Papanicolaou stain. RESULTS: Clinical findings significantly improved after the treatment. ACT scores significantly increased by using propolis (12.8±5.5 before and 18.1±4.99 after the trial), which was significantly higher than the placebo group (14.4±6.6 after the trial). The most significant physiological improvements were significant increases in FEV1, FV1/Forced vital capacity and expiratory flows. FENO showed significant decreases in the propolis group but increases in the placebo group. Cytological examination of sputum showed that the pattern of inflammation was eosinophilic in 44% subjects with an average eosinophil of 7.2±1.01%. Eosinophilia significantly decreased (p<0.05) by using propolis (7.2±1.01 and 4.3±3.1%, before and after treatment, respectively), but it significantly increased (p<0.04) in the placebo group (5.5±2.8, and 11.1±6.6%, before and after treatment, respectively). CONCLUSION: Propolis improved the clinical and physiological findings of moderate persistent asthma, and it was able to suppress eosinophilic inflammation.
OBJECTIVE: The aims of this study was to determine the effect of Propolis (resinous mixture that honey bees produce by mixing saliva and beeswax) on clinical and physiological findings of moderate persistent asthma. MATERIALS AND METHODS: Fifty-two subjects aged 44.6±18.5 years old with moderate asthma and Forced expiratory volume in 1 second (FEV1) 60-79% of predicted, were enrolled in this clinical trial. We randomly allocated subjects to receive either propolis (75 mg three times a day) or a matched placebo for one month. Primary outcome was Asthma control test (ACT) score and secondary outcomes included dyspnea, spirometry, fractional exhaled nitric oxide (FENO) and sputum cytology including inflammatory cell. Sputum induction was done by hypertonic saline and cytology slides were stained by Papanicolaou stain. RESULTS: Clinical findings significantly improved after the treatment. ACT scores significantly increased by using propolis (12.8±5.5 before and 18.1±4.99 after the trial), which was significantly higher than the placebo group (14.4±6.6 after the trial). The most significant physiological improvements were significant increases in FEV1, FV1/Forced vital capacity and expiratory flows. FENO showed significant decreases in the propolis group but increases in the placebo group. Cytological examination of sputum showed that the pattern of inflammation was eosinophilic in 44% subjects with an average eosinophil of 7.2±1.01%. Eosinophilia significantly decreased (p<0.05) by using propolis (7.2±1.01 and 4.3±3.1%, before and after treatment, respectively), but it significantly increased (p<0.04) in the placebo group (5.5±2.8, and 11.1±6.6%, before and after treatment, respectively). CONCLUSION: Propolis improved the clinical and physiological findings of moderate persistent asthma, and it was able to suppress eosinophilic inflammation.
Authors: José Hidelbland Cavalcante de Farias; Aramys Silva Reis; Marcio Antonio Rodrigues Araújo; Maria José Abigail Mendes Araújo; Anne Karine Martins Assunção; Jardel Cavalcante de Farias; Eder Magalhães Silva Fialho; Lucilene Amorim Silva; Graciomar Conceição Costa; Rosane Nassar Meireles Guerra; Maria Nilce Sousa Ribeiro; Flávia Raquel Fernandes do Nascimento Journal: Evid Based Complement Alternat Med Date: 2014-04-01 Impact factor: 2.629
Authors: Kong Yen Liew; Nurain Irdayani Kamise; Hui Ming Ong; Poi Yi Aw Yong; Fahmida Islam; Ji Wei Tan; Chau Ling Tham Journal: Front Pharmacol Date: 2022-01-21 Impact factor: 5.810