BACKGROUND: Race has been shown to have variable prognostic importance in nasopharyngeal carcinoma (NPC). However, previous studies are limited by a lack of comprehensive treatment, epidemiologic, and comorbidity data. METHODS: This was a retrospective cohort study utilizing the National Cancer Database from 2004 to 2016. Multivariable Cox proportional hazards regressions were used to calculate adjusted hazard ratios (aHR) for overall survival. RESULTS: A cohort of 9995 patients met inclusion and exclusion criteria. Race, insurance, comorbidity, treatment, stage, age, and histology were independent prognosticators. Among patients with keratinizing NPC, Asians and Hispanics had superior survival (aHR 0.58 [95% confidence interval (CI) 0.48-0.69], aHR 0.76 [95% CI 0.61-0.96]) compared to white patients. Among patients with non-keratinizing differentiated NPC, Asians and black patients had improved survival (aHR 0.71 [95% CI 0.56-0.91], aHR 0.72 [95% CI 0.54-0.95]) compared to white patients. Race was not prognostic in non-keratinizing undifferentiated NPC. CONCLUSION: The prognostic significance of race varies across histological subtypes of NPC.
BACKGROUND: Race has been shown to have variable prognostic importance in nasopharyngeal carcinoma (NPC). However, previous studies are limited by a lack of comprehensive treatment, epidemiologic, and comorbidity data. METHODS: This was a retrospective cohort study utilizing the National Cancer Database from 2004 to 2016. Multivariable Cox proportional hazards regressions were used to calculate adjusted hazard ratios (aHR) for overall survival. RESULTS: A cohort of 9995 patients met inclusion and exclusion criteria. Race, insurance, comorbidity, treatment, stage, age, and histology were independent prognosticators. Among patients with keratinizing NPC, Asians and Hispanics had superior survival (aHR 0.58 [95% confidence interval (CI) 0.48-0.69], aHR 0.76 [95% CI 0.61-0.96]) compared to white patients. Among patients with non-keratinizing differentiated NPC, Asians and black patients had improved survival (aHR 0.71 [95% CI 0.56-0.91], aHR 0.72 [95% CI 0.54-0.95]) compared to white patients. Race was not prognostic in non-keratinizing undifferentiated NPC. CONCLUSION: The prognostic significance of race varies across histological subtypes of NPC.
Authors: David E Nelson; Paul Mowery; Kat Asman; Linda L Pederson; Patrick M O'Malley; Ann Malarcher; Edward W Maibach; Terry F Pechacek Journal: Am J Public Health Date: 2008-04-01 Impact factor: 9.308
Authors: Miia Ruuskanen; Reidar Grenman; Ilmo Leivo; Tero Vahlberg; Antti Mäkitie; Kauko Saarilahti; Tuija Wigren; Merja Korpela; Leena Voutilainen; Petri Koivunen; Heikki Irjala; Heikki Minn Journal: Acta Oncol Date: 2017-07-07 Impact factor: 4.089
Authors: Alejandro Vazquez; Mohemmed N Khan; Satish Govindaraj; Soly Baredes; Jean Anderson Eloy Journal: Int Forum Allergy Rhinol Date: 2014-04-14 Impact factor: 3.858