Thomas Sartoretti1,2,3, Elisabeth Sartoretti1,2, Michael Wyss1,4, Manoj Mannil5, Luuk van Smoorenburg1, Barbara Eichenberger1, Carolin Reischauer6,7, Alex Alfieri8, Christoph Binkert1, Sabine Sartoretti-Schefer1. 1. Institute of Radiology, Kantonsspital Winterthur, Winterthur, Switzerland. 2. Faculty of Medicine, University of Zürich, Zürich, Switzerland. 3. Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, the Netherlands. 4. Philips Healthsystems, Zürich, Switzerland. 5. Institute of Neuroradiology, Kantonsspital Aarau, Aarau, Switzerland. 6. Department of Medicine, University of Fribourg, Fribourg, Switzerland. 7. Department of Radiology, HFR Fribourg-Hôpital Cantonal, Fribourg, Switzerland. 8. Department of Neurosurgery, Kantonsspital Winterthur, Winterthur, Switzerland.
Abstract
OBJECTIVES: Diffusion-weighted imaging (DWI) plays a crucial role in the diagnosis of ischemic stroke. We assessed the value of computed and acquired high b-value DWI in comparison with conventional b = 1000 s mm-2 DWI for ischemic stroke at 3T. METHODS: We included 36 patients with acute ischemic stroke who presented with diffusion abnormalities on DWI performed within 24 h of symptom onset. B-values of 0, 500, 1000 and 2000 s mm-2 were acquired. Synthetic images with b-values of 1000, 1500, 2000 and 2500 s mm-2 were computed. Two readers compared synthetic (syn) and acquired (acq) b = 2000 s mm-2 images with acquired b = 1000 s mm-2 images in terms of lesion detection rate, image quality, presence of uncertain hyperintensities and lesion conspicuity. Readers also selected their preferred b-value. Contrast ratio (CR) measurements were performed. Non-parametrical statistical tests and weighted Cohens' κ tests were computed. RESULTS: Syn1000 and syn1500 matched acq1000 images in terms of lesion detection rate, image quality and presence of uncertain hyperintensities but presented with significantly improved lesion conspicuity (p < 0.01) and were frequently selected as preferred b-values. Acq2000 images exhibited a similar lesion detection rate and improved lesion conspicuity (p < 0.01) but worse image quality (p < 0.01) than acq1000 images. Syn2000 and syn2500 images performed significantly worse (p < 0.01) than acq1000 images in most or all categories. CR significantly increased with increasing b-values. CONCLUSION: Synthetic images at b = 1000 and 1500 s mm-2 and acquired DWI images at b = 2000 s mm-2 may be of clinical value due to improved lesion conspicuity. ADVANCES IN KNOWLEDGE: Synthetic b-values enable improved lesion conspicuity for DWI of ischemic stroke.
OBJECTIVES: Diffusion-weighted imaging (DWI) plays a crucial role in the diagnosis of ischemic stroke. We assessed the value of computed and acquired high b-value DWI in comparison with conventional b = 1000 s mm-2 DWI for ischemic stroke at 3T. METHODS: We included 36 patients with acute ischemic stroke who presented with diffusion abnormalities on DWI performed within 24 h of symptom onset. B-values of 0, 500, 1000 and 2000 s mm-2 were acquired. Synthetic images with b-values of 1000, 1500, 2000 and 2500 s mm-2 were computed. Two readers compared synthetic (syn) and acquired (acq) b = 2000 s mm-2 images with acquired b = 1000 s mm-2 images in terms of lesion detection rate, image quality, presence of uncertain hyperintensities and lesion conspicuity. Readers also selected their preferred b-value. Contrast ratio (CR) measurements were performed. Non-parametrical statistical tests and weighted Cohens' κ tests were computed. RESULTS: Syn1000 and syn1500 matched acq1000 images in terms of lesion detection rate, image quality and presence of uncertain hyperintensities but presented with significantly improved lesion conspicuity (p < 0.01) and were frequently selected as preferred b-values. Acq2000 images exhibited a similar lesion detection rate and improved lesion conspicuity (p < 0.01) but worse image quality (p < 0.01) than acq1000 images. Syn2000 and syn2500 images performed significantly worse (p < 0.01) than acq1000 images in most or all categories. CR significantly increased with increasing b-values. CONCLUSION: Synthetic images at b = 1000 and 1500 s mm-2 and acquired DWI images at b = 2000 s mm-2 may be of clinical value due to improved lesion conspicuity. ADVANCES IN KNOWLEDGE: Synthetic b-values enable improved lesion conspicuity for DWI of ischemic stroke.
Authors: Y Ueno; S Takahashi; Y Ohno; K Kitajima; M Yui; Y Kassai; F Kawakami; H Miyake; K Sugimura Journal: Br J Radiol Date: 2015-01-21 Impact factor: 3.039
Authors: Thomas Sartoretti; Luuk van Smoorenburg; Elisabeth Sartoretti; Árpád Schwenk; Christoph A Binkert; Zsolt Kulcsár; Anton S Becker; Nicole Graf; Michael Wyss; Sabine Sartoretti-Schefer Journal: Invest Radiol Date: 2020-05 Impact factor: 6.016
Authors: Thomas Sartoretti; Elisabeth Sartoretti; Michael Wyss; Árpád Schwenk; Luuk van Smoorenburg; Barbara Eichenberger; Arash Najafi; Christoph Binkert; Anton S Becker; Sabine Sartoretti-Schefer Journal: Eur J Radiol Date: 2019-09-14 Impact factor: 3.528
Authors: Jung Hyun Park; Bo La Yun; Mijung Jang; Hye Shin Ahn; Sun Mi Kim; Soo Hyun Lee; Eunyoung Kang; Eun-Kyu Kim; So Yeon Park Journal: J Magn Reson Imaging Date: 2018-08-21 Impact factor: 4.813
Authors: Andrew B Rosenkrantz; Nainesh Parikh; Andrea S Kierans; Max Xiangtian Kong; James S Babb; Samir S Taneja; Justin M Ream Journal: Acad Radiol Date: 2016-03-15 Impact factor: 3.173
Authors: Elisabeth Sartoretti; Sabine Sartoretti-Schefer; Luuk van Smoorenburg; Barbara Eichenberger; Árpád Schwenk; David Czell; Alex Alfieri; Andreas Gutzeit; Manoj Mannil; Christoph A Binkert; Michael Wyss; Thomas Sartoretti Journal: Eur J Radiol Open Date: 2021-09-22