Literature DB >> 33476936

Refactoring biosynthetic gene clusters for heterologous production of microbial natural products.

Lei Li1, Logan W Maclntyre1, Sean F Brady2.   

Abstract

Microbial natural products (NPs) are of paramount importance in human medicine, animal health and plant crop protection. Large-scale microbial genome and metagenomic mining has revealed tremendous biosynthetic potential to produce new NPs. However a majority of NP biosynthetic gene clusters (BGCs) are functionally inaccessible under standard laboratory conditions. BGC refactoring and heterologous expression provide a promising synthetic biology approach to NP discovery, yield optimization and combinatorial biosynthesis studies. In this review, we summarize the recent advances pertaining to the heterologous production of bacterial and fungal NPs, with an emphasis on next-generation transcriptional regulatory modules, novel BGC refactoring techniques and optimized heterologous hosts.
Copyright © 2021 Elsevier Ltd. All rights reserved.

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Year:  2021        PMID： 33476936      PMCID： PMC8238852          DOI： 10.1016/j.copbio.2020.12.011

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   10.279


  56 in total

1.  Direct Pathway Cloning Combined with Sequence- and Ligation-Independent Cloning for Fast Biosynthetic Gene Cluster Refactoring and Heterologous Expression.

Authors:  Paul M D'Agostino; Tobias A M Gulder
Journal:  ACS Synth Biol       Date:  2018-07-03       Impact factor: 5.110

2.  mpCRISTAR: Multiple Plasmid Approach for CRISPR/Cas9 and TAR-Mediated Multiplexed Refactoring of Natural Product Biosynthetic Gene Clusters.

Authors:  Hiyoung Kim; Chang-Hun Ji; Hyun-Woo Je; Jong-Pyung Kim; Hahk-Soo Kang
Journal:  ACS Synth Biol       Date:  2019-12-19       Impact factor: 5.110

3.  Heterologous production of myxobacterial α-pyrone antibiotics in Myxococcus xanthus.

Authors:  Hilda Sucipto; Domen Pogorevc; Eva Luxenburger; Silke C Wenzel; Rolf Müller
Journal:  Metab Eng       Date:  2017-10-10       Impact factor: 9.783

4.  Natural Product Discovery through Improved Functional Metagenomics in Streptomyces.

Authors:  Hala A Iqbal; Lila Low-Beinart; Joseph U Obiajulu; Sean F Brady
Journal:  J Am Chem Soc       Date:  2016-07-22       Impact factor: 15.419

5.  A New Golden Age of Natural Products Drug Discovery.

Authors:  Ben Shen
Journal:  Cell       Date:  2015-12-03       Impact factor: 41.582

6.  Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters.

Authors:  Juan Pablo Gomez-Escribano; Mervyn J Bibb
Journal:  Microb Biotechnol       Date:  2010-10-26       Impact factor: 5.813

7.  A set of synthetic versatile genetic control elements for the efficient expression of genes in Actinobacteria.

Authors:  Lilya Horbal; Theresa Siegl; Andriy Luzhetskyy
Journal:  Sci Rep       Date:  2018-01-11       Impact factor: 4.379

8.  ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes.

Authors:  Hailong Wang; Zhen Li; Ruonan Jia; Jia Yin; Aiying Li; Liqiu Xia; Yulong Yin; Rolf Müller; Jun Fu; A Francis Stewart; Youming Zhang
Journal:  Nucleic Acids Res       Date:  2018-03-16       Impact factor: 16.971

9.  Metagenomic mining of regulatory elements enables programmable species-selective gene expression.

Authors:  Nathan I Johns; Antonio L C Gomes; Sung Sun Yim; Anthony Yang; Tomasz Blazejewski; Christopher S Smillie; Mark B Smith; Eric J Alm; Sriram Kosuri; Harris H Wang
Journal:  Nat Methods       Date:  2018-03-19       Impact factor: 28.547

10.  Engineering of Streptomyces lividans for heterologous expression of secondary metabolite gene clusters.

Authors:  Yousra Ahmed; Yuriy Rebets; Marta Rodríguez Estévez; Josef Zapp; Maksym Myronovskyi; Andriy Luzhetskyy
Journal:  Microb Cell Fact       Date:  2020-01-09       Impact factor: 5.328
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  6 in total

Review 1.  Cyanobacterial secondary metabolites towards improved commercial significance through multiomics approaches.

Authors:  Shaloo Verma; Shobit Thapa; Nahid Siddiqui; Hillol Chakdar
Journal:  World J Microbiol Biotechnol       Date:  2022-04-29       Impact factor: 3.312

2.  Harnessing Rare Actinomycete Interactions and Intrinsic Antimicrobial Resistance Enables Discovery of an Unusual Metabolic Inhibitor.

Authors:  Dylan J McClung; Yongle Du; Dominic J Antonich; Bailey Bonet; Wenjun Zhang; Matthew F Traxler
Journal:  mBio       Date:  2022-05-24       Impact factor: 7.786

Review 3.  Mining for novel antibiotics.

Authors:  Justin R Randall; Bryan W Davies
Journal:  Curr Opin Microbiol       Date:  2021-07-02       Impact factor: 7.584

Review 4.  Recent Advances in Strategies for the Cloning of Natural Product Biosynthetic Gene Clusters.

Authors:  Wenfang Wang; Guosong Zheng; Yinhua Lu
Journal:  Front Bioeng Biotechnol       Date:  2021-07-13

Review 5.  Novel Alkaloids from Marine Actinobacteria: Discovery and Characterization.

Authors:  Anne-Sofie De Rop; Jeltien Rombaut; Thomas Willems; Marilyn De Graeve; Lynn Vanhaecke; Paco Hulpiau; Sofie L De Maeseneire; Maarten L De Mol; Wim K Soetaert
Journal:  Mar Drugs       Date:  2021-12-22       Impact factor: 5.118

6.  A comparative metabologenomic approach reveals mechanistic insights into Streptomyces antibiotic crypticity.

Authors:  Yunci Qi; Keshav K Nepal; Joshua A V Blodgett
Journal:  Proc Natl Acad Sci U S A       Date:  2021-08-03       Impact factor: 11.205
  6 in total

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