Literature DB >> 26638061

A New Golden Age of Natural Products Drug Discovery.

Ben Shen1.   

Abstract

The 2015 Nobel Prize in Physiology or Medicine has been awarded to William C. Campbell, Satoshi Omura, and Youyou Tu for the discovery of avermectins and artemisinin, respectively, therapies that revolutionized the treatment of devastating parasite diseases. With the recent technological advances, a New Golden Age of natural products drug discovery is dawning.
Copyright © 2015 Elsevier Inc. All rights reserved.

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Year:  2015        PMID： 26638061      PMCID： PMC5070666          DOI： 10.1016/j.cell.2015.11.031

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  14 in total

1.  Organization of the biosynthetic gene cluster for the polyketide anthelmintic macrolide avermectin in Streptomyces avermitilis.

Authors:  H Ikeda; T Nonomiya; M Usami; T Ohta; S Omura
Journal:  Proc Natl Acad Sci U S A       Date:  1999-08-17       Impact factor: 11.205

2.  The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine.

Authors:  Youyou Tu
Journal:  Nat Med       Date:  2011-10-11       Impact factor: 53.440

3.  Genome neighborhood network reveals insights into enediyne biosynthesis and facilitates prediction and prioritization for discovery.

Authors:  Jeffrey D Rudolf; Xiaohui Yan; Ben Shen
Journal:  J Ind Microbiol Biotechnol       Date:  2015-08-29       Impact factor: 3.346

Review 4.  The life and times of ivermectin - a success story.

Authors:  Satoshi Omura; Andy Crump
Journal:  Nat Rev Microbiol       Date:  2004-12       Impact factor: 60.633

Review 5.  Natural products as sources of new drugs over the 30 years from 1981 to 2010.

Authors:  David J Newman; Gordon M Cragg
Journal:  J Nat Prod       Date:  2012-02-08       Impact factor: 4.050

6.  A new antibiotic kills pathogens without detectable resistance.

Authors:  Losee L Ling; Tanja Schneider; Aaron J Peoples; Amy L Spoering; Ina Engels; Brian P Conlon; Anna Mueller; Till F Schäberle; Dallas E Hughes; Slava Epstein; Michael Jones; Linos Lazarides; Victoria A Steadman; Douglas R Cohen; Cintia R Felix; K Ashley Fetterman; William P Millett; Anthony G Nitti; Ashley M Zullo; Chao Chen; Kim Lewis
Journal:  Nature       Date:  2015-01-07       Impact factor: 49.962

Review 7.  Ivermectin: panacea for resource-poor communities?

Authors:  Satoshi Omura; Andy Crump
Journal:  Trends Parasitol       Date:  2014-08-12

8.  Chemical-biogeographic survey of secondary metabolism in soil.

Authors:  Zachary Charlop-Powers; Jeremy G Owen; Boojala Vijay B Reddy; Melinda A Ternei; Sean F Brady
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-18       Impact factor: 11.205

Review 9.  Ivermectin, an antiparasitic agent.

Authors:  W C Campbell
Journal:  Med Res Rev       Date:  1993-01       Impact factor: 12.944

Review 10.  Qinghaosu (artemisinin): an antimalarial drug from China.

Authors:  D L Klayman
Journal:  Science       Date:  1985-05-31       Impact factor: 47.728
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  137 in total

Review 1.  Opportunities for plant natural products in infection control.

Authors:  Akram M Salam; Cassandra L Quave
Journal:  Curr Opin Microbiol       Date:  2018-09-13       Impact factor: 7.934

2.  Isolation and identification of new macrocyclic lactones from a genetically engineered strain Streptomyces bingchenggensis BCJ60.

Authors:  Jiansong Li; Shaoyong Zhang; Hui Zhang; Haiyan Wang; Ji Zhang; Anliang Chen; Jidong Wang; Wensheng Xiang
Journal:  J Antibiot (Tokyo)       Date:  2016-10-26       Impact factor: 2.649

3.  Madurastatin B3, a rare aziridine derivative from actinomycete Nocardiopsis sp. LS150010 with potent anti-tuberculosis activity.

Authors:  Xinjun Zhang; Hongtao He; Rong Ma; Zengchun Ji; Qi Wei; Huanqin Dai; Lixin Zhang; Fuhang Song
Journal:  J Ind Microbiol Biotechnol       Date:  2017-02-08       Impact factor: 3.346

Review 4.  Challenges and opportunities for natural product discovery, production, and engineering in native producers versus heterologous hosts.

Authors:  Christiana N Teijaro; Ajeeth Adhikari; Ben Shen
Journal:  J Ind Microbiol Biotechnol       Date:  2018-11-13       Impact factor: 3.346

Review 5.  Leveraging a large microbial strain collection for natural product discovery.

Authors:  Andrew D Steele; Christiana N Teijaro; Dong Yang; Ben Shen
Journal:  J Biol Chem       Date:  2019-09-30       Impact factor: 5.157

6.  The role of natural products in revealing NRF2 function.

Authors:  Donna D Zhang; Eli Chapman
Journal:  Nat Prod Rep       Date:  2020-05-13       Impact factor: 13.423

7.  Total Synthesis, Biological Evaluation, and Target Identification of Rare Abies Sesquiterpenoids.

Authors:  Dexter C Davis; Dominic G Hoch; Li Wu; Daniel Abegg; Brandon S Martin; Zhong-Yin Zhang; Alexander Adibekian; Mingji Dai
Journal:  J Am Chem Soc       Date:  2018-12-06       Impact factor: 15.419

8.  Ribosome engineering and fermentation optimization leads to overproduction of tiancimycin A, a new enediyne natural product from Streptomyces sp. CB03234.

Authors:  Ling Liu; Jian Pan; Zilong Wang; Xiaohui Yan; Dong Yang; Xiangcheng Zhu; Ben Shen; Yanwen Duan; Yong Huang
Journal:  J Ind Microbiol Biotechnol       Date:  2018-02-02       Impact factor: 3.346

9.  How to rekindle drug discovery process through integrative therapeutic targeting?

Authors:  Ashok Vaidya; Anuradha Roy; Rathnam Chaguturu
Journal:  Expert Opin Drug Discov       Date:  2018-08-27       Impact factor: 6.098

10.  Discovery of novel small molecule inhibitors of cardiac hypertrophy using high throughput, high content imaging.

Authors:  Brian G Reid; Matthew S Stratton; Samantha Bowers; Maria A Cavasin; Kimberley M Demos-Davies; Isidro Susano; Timothy A McKinsey
Journal:  J Mol Cell Cardiol       Date:  2016-04-27       Impact factor: 5.000
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