| Literature DB >> 33420494 |
Muneaki Nakamura1, Yuchen Gao1,2,3, Antonia A Dominguez1,4, Lei S Qi5,6,7.
Abstract
The epigenome involves a complex set of cellular processes governing genomic activity. Dissecting this complexity necessitates the development of tools capable of specifically manipulating these processes. The repurposing of prokaryotic CRISPR systems has allowed for the development of diverse technologies for epigenome engineering. Here, we review the state of currently achievable epigenetic manipulations along with corresponding applications. With future optimization, CRISPR-based epigenomic editing stands as a set of powerful tools for understanding and controlling biological function.Mesh:
Year: 2021 PMID: 33420494 DOI: 10.1038/s41556-020-00620-7
Source DB: PubMed Journal: Nat Cell Biol ISSN: 1465-7392 Impact factor: 28.824