| Literature DB >> 26296162 |
Jiamu Du1, Lianna M Johnson2, Steven E Jacobsen2, Dinshaw J Patel3.
Abstract
Methylation of DNA and of histone 3 at Lys 9 (H3K9) are highly correlated with gene silencing in eukaryotes from fungi to humans. Both of these epigenetic marks need to be established at specific regions of the genome and then maintained at these sites through cell division. Protein structural domains that specifically recognize methylated DNA and methylated histones are key for targeting enzymes that catalyse these marks to appropriate genome sites. Genetic, genomic, structural and biochemical data reveal connections between these two epigenetic marks, and these domains mediate much of the crosstalk.Entities:
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Year: 2015 PMID： 26296162 PMCID： PMC4672940 DOI： 10.1038/nrm4043
Source DB: PubMed Journal: Nat Rev Mol Cell Biol ISSN： 1471-0072 Impact factor: 94.444